C. Galdeano

发表

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli

K. Read, S. Rocha, Julianty Frost, 2017, Journal of medicinal chemistry.

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Pedro Soares, Sarah Hewitt, Alessio Ciulli, 2014, Journal of medicinal chemistry.

Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?

C. Geraldes, A. Ciulli, M. Baud, 2013, ACS medicinal chemistry letters.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2020, Neurotherapeutics.

Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis

D. Muñoz-Torrero, F. J. Pérez-Areales, C. Galdeano, 2022, Pharmaceuticals.

Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents

P. Camps, D. Muñoz-Torrero, A. Badía, 2012, Neurodegenerative Diseases.

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

M. Bartolini, I. Silman, P. Renard, 2018, Molecules.

Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: role of Asn181 and Ile335 validated by spectroscopic and computational studies.

F. J. Luque, J. Juárez-Jiménez, R. Ramsay, 2014, Biochimica et biophysica acta.

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

F. J. Luque, V. Andrisano, M. Bartolini, 2012, Journal of medicinal chemistry.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2009, Journal of medicinal chemistry.

Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts

P. Camps, D. Muñoz-Torrero, T. Calvet, 2011 .

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

P. Grandi, K. Read, M. Bantscheff, 2016, Nature Communications.

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

F. J. Luque, Vincenza Andrisano, Albert Badia, 2010, ChemMedChem.

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

F. J. Luque, V. Andrisano, M. Bartolini, 2010, Chemico-biological interactions.

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.

A. Fairlamb, S. Y. Gbedema, D. Muñoz-Torrero, 2015, Bioorganic & medicinal chemistry.

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents

P. Camps, D. Muñoz-Torrero, M. Taylor, 2011, Bioorganic & medicinal chemistry.

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

F. J. Luque, Ornella Di Pietro, R. Lamuela-Raventós, 2014, Bioorganic & medicinal chemistry.

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy

M. Pallàs, S. Vázquez, C. Sanfeliu, 2020, Biomolecules.

Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology

Alessio Ciulli, A. Ciulli, Carles Galdeano, 2016, Future medicinal chemistry.

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

F. J. Luque, V. Andrisano, M. Bartolini, 2008, Journal of medicinal chemistry.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2020, Neurotherapeutics.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2019, Neurotherapeutics.

Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

P. Camps, M. Salmona, L. Diomede, 2015, Molecules.

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors.

R. Sabaté, A. Espargaró, S. Ventura, 2014, Current medicinal chemistry.

Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.

X. Barril, F. von Delft, P. Filippakopoulos, 2021, Journal of medicinal chemistry.

Highly diastereoselective one-pot synthesis of spiro[cyclopenta[a]indene-2,2'-indene]diones from 1-indanones and aromatic aldehydes.

P. Camps, L. Domingo, D. Muñoz-Torrero, 2006, The Journal of organic chemistry.

Modulating Ligand Dissociation Through Methyl Isomerism in Accessory Sites: Binding of Retinol to Cellular Carriers.

F. Spyrakis, F. Gervasio, G. Saladino, 2019, Journal of Physical Chemistry Letters.

Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents.

A. Bidon-Chanal, D. Muñoz-Torrero, E. Viayna, 2010, Current pharmaceutical design.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

V. Andrisano, M. Bartolini, F. Mancini, 2009, Journal of medicinal chemistry.

Drugging the undruggable: targeting challenging E3 ligases for personalized medicine.

C. Galdeano, 2017, Future medicinal chemistry.

Synthesis, Characterization and HPLC Analysis of the (1S,2S,5R)-Diastereomer and the Enantiomer of the Clinical Candidate AR-15512

Eugènia Pujol, C. Escolano, S. Vázquez, 2021, Molecules.