L. Ellis

发表

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli

K. Read, S. Rocha, Julianty Frost, 2017, Journal of medicinal chemistry.

Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition† †Electronic supplementary information (ESI) available: Supplemental results (Fig. S1–S13 and Tables S1–S10). Crystallography data collection and refinement statistics. Experimental section. Detailed compound s

K. Read, A. Ciulli, M. Baud, 2018, Chemical science.

Discovery of pro-soft drug modulators of sphingosine-1-phosphate receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2020 .

University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2017 .

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

P. Grandi, K. Read, M. Bantscheff, 2016, Nature Communications.

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Thomas R. Ioerger, Travis Hartman, Tom L. Blundell, 2017, ACS infectious diseases.

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Ian H Gilbert, Manu De Rycker, Sujatha Manthri, 2017, ACS infectious diseases.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

K. Read, K. Chibale, T. Ioerger, 2018, ACS infectious diseases.

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2019, ACS medicinal chemistry letters.