Kwok-Ho Chan

发表

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

A. Ciulli, X. Lucas, A. Runcie, 2018, Journal of the American Chemical Society.

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

D. Alessi, J. Blow, Thomas Macartney, 2021, Journal of medicinal chemistry.

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Nancy Murphy, D. Daniels, M. Urh, 2021, Nature Chemical Biology.

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

Chad E. Townsend, R. Lokey, A. Ciulli, 2020, ACS medicinal chemistry letters.

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

A. Ciulli, A. Testa, Kwok-Ho Chan, 2017, Journal of medicinal chemistry.

Trivalent PROTACs enhance protein degradation through cooperativity and avidity

Nancy Murphy, D. Daniels, M. Urh, 2020 .

University of Dundee Selective small molecule induced degradation of the BET bromodomain protein BRD 4

A. Ciulli, Kwok-Ho Chan, 2015 .

Structural basis of PROTAC cooperative recognition for selective protein degradation

D. Lamont, A. Ciulli, X. Lucas, 2017, Nature chemical biology.

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

A. Ciulli, Kwok-Ho Chan, M. Zengerle, 2015, ACS chemical biology.

Chemical genetics approaches for selective intervention in epigenetics

A. Ciulli, A. Runcie, Kwok-Ho Chan, 2016, Current opinion in chemical biology.

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Kwok-Ho Chan, Michael Zengerle, Alessio Ciulli, 2014, Science.

1 Title : Structural basis of PROTAC cooperative recognition for selective protein 1 degradation 2

D. Lamont, A. Ciulli, X. Lucas, 2017 .

Interaction between Hydrogenase Maturation Factors HypA and HypB Is Required for [NiFe]-Hydrogenase Maturation

Kam-Bo Wong, Ka-man Lee, Kwok-Ho Chan, 2012, PloS one.

Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3.

Thomas Macartney, Albert Isidro-Llobet, Thomas J. Macartney, 2023, Cell chemical biology.

Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition† †Electronic supplementary information (ESI) available: Supplemental results (Fig. S1–S13 and Tables S1–S10). Crystallography data collection and refinement statistics. Experimental section. Detailed compound s

K. Read, A. Ciulli, M. Baud, 2018, Chemical science.