D. Cashen

发表

A role for the melanocortin 4 receptor in sexual function

Christopher P Austin, Ralph Stearns, G. Christ, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula.

L. Gantert, D. Macintyre, L. V. D. van der Ploeg, 2002, European journal of pharmacology.

Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.

Roy G. Smith, A. Patchett, J. Schaeffer, 2006, Endocrinology.

Acidic fibroblast growth factor accelerates dermal wound healing in diabetic mice.

J. Ronan, K. Thomas, D. Cashen, 1995, The Journal of investigative dermatology.

Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk‐induced gall bladder emptying in mice

B. Wiedenmann, J. Schaeffer, K. Chapman, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

D. Macintyre, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.

J. Metzger, D. Macintyre, L. V. D. van der Ploeg, 2005, Bioorganic & Medicinal Chemistry Letters.

Acidic fibroblast growth factor accelerates dermal wound healing.

M. James, G. Giménez-Gallego, J. Ronan, 1992, Growth factors.

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

D. Macintyre, Howard Y. Chen, R. Nargund, 2011, Bioorganic & medicinal chemistry letters.

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

J. Metzger, L. V. D. van der Ploeg, C. Rosenblum, 2010, Bioorganic & medicinal chemistry letters.

Effects of sildenafil on erectile activity in mice lacking neuronal or endothelial nitric oxide synthase

W. Martin, D. Cashen, D. MacIntyre, 2002, British journal of pharmacology.

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.

D. Johnston, D. Macintyre, L. V. D. van der Ploeg, 2002, Journal of medicinal chemistry.

3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.

V. Warren, M. Fisher, K. Lyons, 2008, Bioorganic & medicinal chemistry letters.