B. Goldstein

发表

A link between protein structure and enzyme catalyzed hydrogen tunneling.

J. Klinman, B. Bahnson, J P Klinman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The Chemistry of Nucleoside and Dinucleotide Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)1

K. Pankiewicz, B. Goldstein, 2002 .

The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: inhibition of human inosine monophosphate dehydrogenase (type I and II).

A. Zatorski, K. Watanabe, Kyoichi A. Watanabe, 1997, Journal of medicinal chemistry.

Chemical synthesis of benzamide adenine dinucleotide: inhibition of inosine monophosphate dehydrogenase (types I and II).

A. Zatorski, K. Watanabe, K. Pankiewicz, 1996, Journal of medicinal chemistry.

Coupling of MBP fusion protein cleavage with sparse matrix crystallization screens to overcome problematic protein solubility.

J. Wedekind, F. Gruswitz, B. Goldstein, 2005, BioTechniques.

Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.

G. D. Markham, T. Colby, B. Goldstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Benign Synthesis of 2-Ethylhexanoic Acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies†

Jeffrey P. Jones, K. French, J. Wahlstrom, 2001 .

Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy.

P. Rowley, J. Leary, V. Marquez, 1991, Blood.

Crystallographic studies on the complex behavior of nicotine binding to P450cam (CYP101).

Jeffrey P. Jones, D. Matteson, B. Goldstein, 2003, Biochemistry.

Crystal and molecular structure of a chiral-specific DNA-binding agent: tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)

H. Berman, J. Barton, B. Goldstein, 1986 .

A database study of nonbonded intramolecular sulfur-nucleophile contacts.

B. Goldstein, F. T. Burling, 1993, Acta crystallographica. Section B, Structural science.

Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.

M. Hollingshead, R. Fuller, G. Arnett, 1989, Journal of medicinal chemistry.

Conformational constraints in NAD analogs: implications for dehydrogenase binding and specificity.

T. Colby, B. Goldstein, 2000, Advances in enzyme regulation.

Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.

G. Perra, P. la Colla, L. Cappellacci, 1997, Journal of medicinal chemistry.

Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.

K. Watanabe, K. Pankiewicz, B. Goldstein, 1998, Journal of medicinal chemistry.

Synthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase

G. Perra, L. Cappellacci, P. Colla, 1997 .

Analogues of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain.

A. Wissner, C. Kohler, B. Goldstein, 1984, Journal of medicinal chemistry.

Potent inhibitors of human inosine monophosphate dehydrogenase type II. Fluorine-substituted analogues of thiazole-4-carboxamide adenine dinucleotide.

A. Zatorski, J. Jones, T. Colby, 1995, Journal of medicinal chemistry.

Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group.

A. Wissner, C. Kohler, B. Goldstein, 1985, Journal of medicinal chemistry.

Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.

H. Li, K. Watanabe, K. Pankiewicz, 1995, Biochemistry.

CNAD: a potent and specific inhibitor of alcohol dehydrogenase.

H. Li, J. Jones, K. Watanabe, 1994, Journal of medicinal chemistry.

Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.

K. Watanabe, J. E. Bell, K. Pankiewicz, 1993, Journal of medicinal chemistry.

A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).

L. Cappellacci, S. Marchetti, P. Franchetti, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.

L. Cappellacci, J. Imbach, P. Franchetti, 2000, Journal of medicinal chemistry.

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

L. Stuyver, R. Schinazi, S. Patterson, 2004, Current medicinal chemistry.

Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.

H L Carrell, H. L. Carrell, H. Li, 1994, Biochemistry.

Selenium-77 NMR and crystallographic studies of selenazofurin and its 5-amino derivative

S. Kennedy, W. Hennen, B. Goldstein, 1990 .

Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.

C. Carrell, L. Cappellacci, A. O'Connor, 1995, Journal of medicinal chemistry.

Computational studies of nonbonded sulfur-oxygen and selenium-oxygen interactions in the thiazole and selenazole nucleosides

F. Temple Burling, Barry M. Goldstein, B. Goldstein, 1992 .

Structural studies of a new antitumor agent: tiazofurin and its inactive analogues

H. Berman, R. K. Robins, F. Takusagawa, 1983 .

Structural studies of a new antitumor and antiviral agent: selenazofurin and its .alpha. anomer

R. K. Robins, F. Takusagawa, B. Goldstein, 1985 .

A transfer nuclear Overhauser effect study of coenzyme binding to distinct sites in binary and ternary complexes in glutamate dehydrogenase.

G. C. Levy, J. E. Bell, H. Levy, 1987, Biochemistry.

Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding.

J. Klinman, B. Bahnson, G. Prehna, 2004, Biochemistry.

Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding.

H. Li, B. Goldstein, 1992, Journal of medicinal chemistry.

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Kyoichi A. Watanabe, K. Pankiewicz, H. Jayaram, 2002, Current medicinal chemistry.

Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine.

A. Zatorski, K. Watanabe, K. Pankiewicz, 1993, Carbohydrate research.

IMP dehydrogenase : structural aspects of inhibitor binding.

T. Colby, B. Goldstein, 1999, Current medicinal chemistry.

Ara-tiazofurin: conservation of structural features in an unusual thiazole nucleoside.

V. Marquez, B. Goldstein, D. T. Mao, 1988, Journal of medicinal chemistry.

Dehydrogenase binding by tiazofurin anabolites.

V. Marquez, J. E. Bell, V E Marquez, 1990, Journal of medicinal chemistry.

Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.

K. Watanabe, K. Pankiewicz, B. Goldstein, 1997, Journal of medicinal chemistry.

Metastable and equilibrium phases in dilute V-N alloys

B. Goldstein, D. Potter, Howard Epstein, 1974, Metallurgical and Materials Transactions B.

Metastable phases in dilute alloys of vanadium with nitrogen

B. Goldstein, D. Potter, Howard Epstein, 1973 .

C-glycosyl bond conformation in oxazofurin: crystallographic and computational studies of the oxazole analogue of tiazofurin.

D. Langs, H. Li, L. Cappellacci, 1994, Journal of medicinal chemistry.

Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.

J. Klinman, B. Bahnson, T. Colby, 1998, Biochemistry.

Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.

V. Marquez, G. Weber, D. Cooney, 1991, Biochemical and biophysical research communications.

Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety.

A. Wissner, C. Kohler, B. Goldstein, 1986, Journal of medicinal chemistry.

IMPDH Structure and Ligand Binding

B. Goldstein, M. Strickler, D. Risal, 2003 .

Inosine monophosphate dehydrogenase : a major therapeutic target

K. Pankiewicz, B. Goldstein, 2003 .

Structure-activity relationships of tiazofurin analogs: synthesis and computational studies of 4'-thio derivatives of thiophenfurin and furanfurin

L. Cappellacci, J. Imbach, S. Marchetti, 1999 .

Crystallization and preliminary X-ray study of a complex between d(ATGCAT) and actinomycin D.

H. Berman, R. Jones, F. Takusagawa, 1984, The Journal of biological chemistry.

Inosine Monophosphate Dehydrogenase and Its Inhibitors: An Overview

K. Pankiewicz, B. Goldstein, 2003 .

Active site mutations of cytochrome p450cam alter the binding, coupling, and oxidation of the foreign substrates (R)- and (s)-2-ethylhexanol.

Jeffrey P. Jones, D. Rock, J. Manchester, 2002, Archives of biochemistry and biophysics.