Jonathan D Wrigley

发表

Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

Michal Bista, David Rueda, Jon A Read, 2017, Nature Communications.

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.

C. Masters, A. Nadin, G. Evin, 2001, The Journal of biological chemistry.

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

A. Nadin, I. Churcher, D. Beher, 2004, Journal of Biological Chemistry.

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

C. Masters, A. Nadin, J. Culvenor, 2003, Biochemistry.

Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

B. de Strooper, A. Nadin, P. Hunt, 2004, Journal of neurochemistry.

Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

D. Beher, M. Shearman, Jonathan D Wrigley, 2002 .

Surface diffusion by an atomic exchange mechanism

Jonathan D Wrigley, J. Wrigley, 1980 .

High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

A. Nadin, Michael A. Reilly, J. Castro, 2003 .

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.

Y. S. Tang, J. Castro, I. Churcher, 2003, Journal of medicinal chemistry.

A new series of potent benzodiazepine γ-secretase inhibitors

I. Churcher, J. W. Butcher, H. Lewis, 2003 .

High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.

A. Nadin, Michael A. Reilly, J. Castro, 2003, Bioorganic & medicinal chemistry letters.

A new series of potent benzodiazepine gamma-secretase inhibitors.

I. Churcher, J. W. Butcher, H. Lewis, 2003, Bioorganic & Medicinal Chemistry Letters.

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Euan R. Kay, R. Mortishire-Smith, Michael A. Reilly, 2006 .

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.

R. Mortishire-Smith, Michael A. Reilly, E. Kay, 2006, Bioorganic & medicinal chemistry letters.

Topological analysis of peripherin/rds and abnormal glycosylation of the pathogenic Pro216-->Leu mutation.

J. Findlay, Jonathan D Wrigley, J. Wrigley, 2002, The Biochemical journal.

BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

M. Firth, Marcello Maresca, Jonathan D Wrigley, 2018, BMC Biology.

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily.

J. Boros, D. M. Andrews, R. Ward, 2017, ACS chemical biology.

Lattice walks by long jumps

Mark E. Twigg, G. Ehrlich, M. Twigg, 1990 .

Two-dimensional random walks of diatomic clusters

G. Ehrlich, Jonathan D Wrigley, 1986 .

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity*

T. Bonnert, D. Beher, M. Shearman, 2005, Journal of Biological Chemistry.

Methionine-rich repeat proteins: a family of membrane-associated proteins which contain unusual repeat regions.

N. Evans, J. Findlay, A. Holzenburg, 2005, Biochimica et biophysica acta.

Cell banking for pharmaceutical research.

R. Hicks, Jonathan D Wrigley, A. Griffen, 2014, Drug discovery today.

Peripherin/rds Influences Membrane Vesicle Morphology

J. Findlay, Jonathan D Wrigley, J. Wrigley, 2000, The Journal of Biological Chemistry.

Atomic jump lengths in surface diffusion: Re, Mo, Ir, and Rh on W(211)

G. Ehrlich, Jonathan D Wrigley, J. Wrigley, 1989 .

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

P. Prasit, B. Muñoz, D. Beher, 2006, Bioorganic & medicinal chemistry letters.