S. Vali

Krishna Kumar Tiwari, A. Weiss, Jessica F Almine, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Computational drug treatment simulations on projections of dysregulated protein networks derived from the myelodysplastic mutanome match clinical response in patients.

F. Solé, R. Bejar, M. Sekeres, 2017, Leukemia research.

Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer

G. K. Johnson, Erliang Zeng, K. Brogden, 2019, Scientific Reports.

Computational Analysis of Genomic Abnormalities from a Phase 3 Trial of Rigosertib in Higher-Risk MDS: Simulation of a Predictive Signature for Clinical Response

B. Brownstein, G. Garcia-Manero, H. Loferer, 2016 .

A Genomic Signature Predicting Venetoclax Treatment Response in AML Identified By Protein Network Mapping and Validated By Ex Vivo Drug Sensitivity Testing: A Beat AML Project Study

B. Druker, C. Tognon, J. Tyner, 2016 .

Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus

J. Cavanaugh, A. Progulske-Fox, K. Brogden, 2013, Scientific Reports.

β‐caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP‐1 protein tyrosine phosphatase

G. Sethi, K. Ahn, Sung-Hoon Kim, 2014, Molecular carcinogenesis.

Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses

G. K. Johnson, K. Brogden, S. Vincent, 2013, Expert review of anti-infective therapy.

Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line

P. Reddanna, Karnati R. Roy, Chandrani Achari, 2010, Cancer Chemotherapy and Pharmacology.

In silico modeling predicts drug sensitivity of patient-derived cancer cells

S. Pastorino, S. Kesari, R. Mukthavaram, 2014, Journal of Translational Medicine.

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs

Taher Abbasi, Shireen Vali, Milan Makale, 2014, Journal of Translational Medicine.

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

Kenneth C. Anderson, Kishan Patel, Shireen Vali, 2010, Molecular Cancer Therapeutics.

Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer

G. K. Johnson, Erliang Zeng, K. Brogden, 2019, Scientific Reports.

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Andrea R. Hallier, T. Braun, T. Chan, 2018, BMC Cancer.

Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study.

K. Brogden, A. Bates, F. Qian, 2017, Oral surgery, oral medicine, oral pathology and oral radiology.

Honokiol inhibits signal transducer and activator of transcription‐3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP‐1

G. Sethi, K. Ahn, Feng Li, 2012, Journal of cellular physiology.

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

Taher Abbasi, Shireen Vali, Gautam Sethi, 2010, Clinical Cancer Research.

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

G. Sethi, Feng Li, A. Kumar, 2011, Journal of Molecular Medicine.

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer*

C. Yap, G. Sethi, K. Ahn, 2012, The Journal of Biological Chemistry.

Computational modeling of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) to identify personalized therapy using genomics.

C. Cogle, B. Shah, G. Chinnaswamy, 2019, Leukemia research.

Celastrol inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells

G. Sethi, Feng Li, A. Kumar, 2011, British journal of pharmacology.

PI3KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma‐induced resistance

R. Vij, A. Azab, F. Azab, 2014, British journal of haematology.

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes*

David E. James, Shireen Vali, Shi-Xiong Tan, 2011, The Journal of Biological Chemistry.

Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide

B. Goh, S. Chong, S. Pervaiz, 2015, Oncotarget.

Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B

A. Progulske-Fox, K. Brogden, A. Bates, 2018, Journal of periodontology.

Computational Biological Modeling Identifies PD-(L)1 Immunotherapy Sensitivity Among Molecular Subgroups of KRAS-Mutated Non–Small-Cell Lung Cancer

J. Neal, H. Wakelee, T. Abbasi, 2021, JCO precision oncology.

Prediction of Outcomes with a Computational Biology Model in Newly Diagnosed Glioblastoma Patients Treated with Radiation Therapy and Temozolomide.

P. Wen, K. Ligon, L. Trippa, 2020, International journal of radiation oncology, biology, physics.

Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.

J. Andersen, Purushottam Sharma, S. Chinta, 2008, Free radical biology & medicine.

Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson’s disease: A dynamic model

J. Padiadpu, J. Andersen, F. Gorin, 2007, Neuroscience.

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

S. McWeeney, B. Druker, C. Tognon, 2019, Leukemia research.

Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis

Poorvi Kaushik, Fredric Gorin, Shireen Vali, 2007, Journal of Computational Neuroscience.

Predictive Simulation Approach for Designing Cancer Therapeutic Regimens with Novel Biological Mechanisms

N. Doudican, A. Agrawal, A. Mazumder, 2014, Journal of Cancer.

A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients.

M. Norkin, Subharup Guha, J. Wingard, 2019, Blood advances.

Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.

Amanda C. Winters, D. Pollyea, C. Jordan, 2019, Leukemia research.

Abstract CT085: iCare 1: A prospective clinical trial to predict treatment response based on mutanome-informed computational biology in patients with AML and MDS

M. Norkin, J. Wingard, C. Cogle, 2017 .

Icare 1: A Prospective Clinical Trial to Predict Treatment Response Based on Mutanome-Informed Computational Biology in Patients with AML and MDS

M. Norkin, J. Wingard, C. Cogle, 2016 .

A Genomic Rule Predicting HMA Treatment Response in MDS Identified By Protein Network Mapping and Validated By Clinical Trial Simulation

R. Bejar, C. Cogle, Pranav Tiwari, 2016 .

A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli

Aditya Barve, V. Ramachandran, S. Datta, 2010, Advances and applications in bioinformatics and chemistry : AABC.

Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers

P. Tan, T. Tan, R. Huang, 2021, Cell death discovery.

A Computer Simulation of Progesterone and Cox2 Inhibitor Treatment for Preterm Labor

C. Hobel, O. Equils, S. Vali, 2010, PloS one.

Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson’s disease

F. Gorin, S. Vali, A. Raichur, 2006, Neuroscience.

Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses

J. Cavanaugh, Jianyi Yang, A. Progulske-Fox, 2014, Scientific Reports.

In silico modeling predicts drug sensitivity of patient-derived cancer cells

S. Pastorino, S. Kesari, R. Mukthavaram, 2014, Journal of Translational Medicine.

Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy

O. El‐Agnaf, S. Usmani, M. Bharath, 2011, Neuroscience.

Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: a novel approach for overcoming resistance in anticancer treatment.

A. Ray, R. Venkataramanan, S. Dastidar, 2011, European journal of pharmacology.

Correction: A Computer Simulation of Progesterone and Cox2 Inhibitor Treatment for Preterm Labor

C. Hobel, O. Equils, S. Vali, 2010, PLoS ONE.

Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype

U. Tatu, S. Vali, S. Kapoor, 2009, Systems and Synthetic Biology.

Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades.

G. Sethi, K. Ahn, Jong Hyun Lee, 2021, European journal of pharmacology.

Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models

K. Brogden, J. Guthmiller, A. Bates, 2016, Cancer Immunology, Immunotherapy.

C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysis.

P. Reddanna, Karnati R. Roy, S. Vali, 2007, Archives of biochemistry and biophysics.

P1.14-17 Identification of Molecular Subtypes of Thymic Epithelial Tumors and Novel Treatments Using a Computational Biological Model

H. Wakelee, S. Badve, Atul Kumar, 2018, Journal of Thoracic Oncology.

A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression.

K. Swaminathan, S. Chong, S. Pervaiz, 2019, Cancer letters.

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells

S. Pastorino, S. Kesari, Ying S. Chao, 2014, British Journal of Cancer.

Aurora Kinase Is a Therapeutic Target in Ibrutinib-Resistant Waldenstrom Macroglobulinemia: In-Silico Target Identification and in-Vitro Validation

A. Chanan-Khan, V. Roy, J. Foran, 2015 .

Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Andrea R. Hallier, N. Rizvi, A. Bossler, 2018, BMC Cancer.

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer*

C. Yap, G. Sethi, K. Ahn, 2012, The Journal of Biological Chemistry.

Advances and Applications in Bioinformatics and Chemistry Dovepress a Kinetic Platform for in Silico Modeling of the Metabolic Dynamics in Escherichia Coli

Aditya Barve, V. Ramachandran, S. Solapure, 2022 .

Role of the sarcoplasmic reticulum in regulating the activity‐dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells

I. Pessah, F. Gorin, S. Vali, 2000, Journal of cellular physiology.