J. L. Buchanan

发表

Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.

S. Hitchcock, Xiaoyang Xia, Yuan Cheng, 2008, Journal of Medicinal Chemistry.

Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.

David P. Carney, P. Gallant, M. Morrison, 2011, Bioorganic & medicinal chemistry letters.

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Xiao Mei Zheng, A. Malmberg, H. Bregman, 2011, Journal of medicinal chemistry.

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.

H. Bregman, S. McDonough, A. Zou, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

A. Malmberg, H. Bregman, S. McDonough, 2012, Bioorganic & medicinal chemistry letters.

Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.

Xiao Mei Zheng, S. Hitchcock, A. Cheng, 2008, Bioorganic & Medicinal Chemistry Letters.

Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.

H. Bregman, J. Newcomb, P. Andrews, 2013, Journal of medicinal chemistry.

Enantioselective synthesis of a halichondrin B C(20)→C(36) precursor

J. L. Buchanan, S. D. Burke, Gan Zhang, 1995 .

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.

J. Newcomb, Xin Huang, Steve Schneider, 2007, Bioorganic & medicinal chemistry letters.

PRACTICAL SYNTHESIS OF FULLY-SUBSTITUTED PEPTIDE THIAZOLES

D. Holt, U. Mani, J. L. Buchanan, 1999 .

Synthesis of a C(22)a˚C(34) halichondrin precursor via a double dioxanone-to-dihydropyran rearrangement

J. Rovin, J. L. Buchanan, S. D. Burke, 1991 .

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Xin Huang, David Powers, Daniela Metz, 2006, Journal of medicinal chemistry.

Structure-based design and synthesis of a novel class of Src SH2 inhibitors.

D. Holt, M. Hatada, R. Bohacek, 1999, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of a novel class of Src SH2 inhibitors.

K. Loiacono, B. Lynch, I. Macneil, 1999, Bioorganic & medicinal chemistry letters.

Total synthesis of (±)-pulo'upone

J. L. Buchanan, S. D. Burke, A. Piscopio, 1988 .

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

A. Cheng, J. Newcomb, Xin Huang, 2007, Bioorganic & medicinal chemistry letters.

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

P. Gallant, M. Morrison, D. Elbaum, 2006, Journal of medicinal chemistry.