Ryan D. White

发表

Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.

S. Hitchcock, Xiaoyang Xia, Yuan Cheng, 2008, Journal of Medicinal Chemistry.

Discovery of 6-Oxo-4-Phenyl-Hexanoic Acid Derivatives as RORγt Inverse Agonists Showing Favorable ADME Profile.

S. Shuto, Keiko Kumazawa, Zhulun Wang, 2021, Bioorganic & medicinal chemistry letters.

Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists.

S. Shuto, Zhulun Wang, Xiaoshan Min, 2020, ACS medicinal chemistry letters.

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

S. Hitchcock, A. Cheng, Yuan Cheng, 2015, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Potent and Selective CK1γ Inhibitors.

H. Bregman, J. Newcomb, Xin Huang, 2012, ACS medicinal chemistry letters.

Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.

Xiao Mei Zheng, S. Hitchcock, A. Cheng, 2008, Bioorganic & Medicinal Chemistry Letters.

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.

Ling Wang, Kelly Regal, Sesha Neervannan, 2008, Journal of medicinal chemistry.

Total synthesis of (+/-)-kalihinol C.

G. Keaney, J. L. Wood, Ryan D. White, 2004, Organic letters.

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.

J. Newcomb, Xin Huang, Steve Schneider, 2007, Bioorganic & medicinal chemistry letters.

Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.

E. Hu, R. Kunz, N. Chen, 2008, Journal of medicinal chemistry.

Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.

S. Hitchcock, A. Cheng, R. Fremeau, 2009, Bioorganic & medicinal chemistry letters.

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Xin Huang, David Powers, Daniela Metz, 2006, Journal of medicinal chemistry.

Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).

R. Wahl, A. Cheng, R. Fremeau, 2014, Journal of medicinal chemistry.

Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

Xiao Mei Zheng, R. Wahl, A. Cheng, 2014, Journal of medicinal chemistry.

RNA binding motif (RBM) proteins: A novel family of apoptosis modulators?

L. Sutherland, Ryan D White, N. D. Rintala-Maki, 2005, Journal of cellular biochemistry.

Structural basis for pharmacological modulation of the TRPC6 channel

S. Ghimire-Rijal, Xinchao Yu, Xin Huang, 2020, eLife.

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.

M. Fielden, D. Whittington, M. Bartberger, 2017, MedChemComm.

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.

Xiao Mei Zheng, R. Wahl, S. Hitchcock, 2015, ACS medicinal chemistry letters.

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

A. Cheng, J. Newcomb, Xin Huang, 2007, Bioorganic & medicinal chemistry letters.

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

P. Gallant, M. Morrison, D. Elbaum, 2006, Journal of medicinal chemistry.

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

O. Homann, P. Cao, H. Yamane, 2016, PloS one.

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.

Yuan Cheng, D. Whittington, M. Bartberger, 2017, MedChemComm.