Weige Zhang

发表

Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy

Lianqing Liu, Enlong Ma, Yanchun Li, 2017, PloS one.

COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma.

Daiying Zuo, Zengqiang Li, Weige Zhang, 2014, Biochemical and biophysical research communications.

Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice

Zedan Wang, Jiang Zheng, Ying Peng, 2019, Drug Metabolism and Disposition.

Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors.

Kai Bao, Yi Dai, X. Yao, 2010, Bioorganic & medicinal chemistry.

Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products.

X. Yao, M. Cheng, Kai Bao, 2009, Organic & biomolecular chemistry.

DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2013, Biological & pharmaceutical bulletin.

Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.

Daiying Zuo, Zi Liu, Zengqiang Li, 2022, Toxicology and applied pharmacology.

Synthesis of few-layer N-doped graphene from expandable graphite with melamine and its application in supercapacitors

Xudong Zhao, Xiaoyang Liu, Qiushi Sun, 2020 .

4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.

Kai Bao, Yingliang Wu, Weige Zhang, 2016, European journal of medicinal chemistry.

3‐(3‐Methoxyphenyl)‐6‐(3‐amino‐4‐methoxyphenyl)‐7H‐[1,2,4] triazolo [3,4‐b][1,3,4] thiadiazine, a novel tubulin inhibitor, evokes G2/M cell cycle arrest and apoptosis in SGC‐7901 and HeLa cells

Daiying Zuo, Zi Liu, Zengqiang Li, 2020, Journal of cellular biochemistry.

Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.

Lingman Ma, Qi Guan, Zhaoshi Bai, 2021, Biochimica et biophysica acta. Molecular cell research.

Survivin Suppression Strengthens BZML-induced Mitotic Catastrophe to Overcome Multidrug Resistance by Removing Senescent A549/Taxol Cells

Lingman Ma, Qi Guan, Zhaoshi Bai, 2020 .

Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors.

Ming-Ju Huang, Qi Guan, Weige Zhang, 2021, European journal of medicinal chemistry.

Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents.

Kai Bao, Daiying Zuo, Yingliang Wu, 2020, Bioorganic chemistry.

Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors.

Kai Bao, Daiying Zuo, Yingliang Wu, 2019, European journal of medicinal chemistry.

Synthesis and bioevaluation of diarylpyrazoles as antiproliferative agents.

Kai Bao, Daiying Zuo, Yingliang Wu, 2019, European journal of medicinal chemistry.

3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation.

Kai Bao, Daiying Zuo, Yingliang Wu, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors.

Kai Bao, Yingliang Wu, Lijing Wang, 2018, European journal of medicinal chemistry.

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

Jian Wang, Kai Bao, Daiying Zuo, 2017, PloS one.

Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors

Kai Bao, Daiying Zuo, Yingliang Wu, 2017, Scientific Reports.

Synthesis and antiproliferative activity of 2-aryl-4-(3,4,5-trimethoxybenzoyl)-1,2,3-triazol derivatives as microtubule-destabilizing agents

Kai Bao, Daiying Zuo, Yingliang Wu, 2017 .

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents.

Kai Bao, Daiying Zuo, Yingliang Wu, 2016, ACS medicinal chemistry letters.

Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.

Nan Jiang, Kai Bao, Daiying Zuo, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2,3-diarylthiophene analogues of combretastatin A-4

Qing‐Zheng Yang, Yingliang Wu, Xuewei Jiang, 2015 .

Synthesis and Biological Evaluation of 3-Alkyl-1,5-Diaryl-1H-Pyrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative Activity

Daiying Zuo, Yingliang Wu, Xuewei Jiang, 2015, PloS one.

Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4.

Chunjian Liu, Kai Bao, Yingliang Wu, 2014, European journal of medicinal chemistry.

3D-QSAR Study of Combretastatin A-4 Analogs Based on Molecular Docking

P. Qi, Weige Zhang, Qirong Shen, 2011, Molecules.

Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors

Kai Bao, Qi Guan, Weige Zhang, 2016 .

2(+/-)-7,8,3',4',5'-Pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells.

T. Ikejima, Enlong Ma, Yanchun Li, 2009, Toxicology in vitro : an international journal published in association with BIBRA.

5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human ﬁbrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest.

Daiying Zuo, Yingliang Wu, Jiwei Shen, 2017, International journal of oncology.

Characteristics and pharmacokinetics of docetaxel liposome containing Tween 80 or PEG-DSPE

Dongkai Wang, Chao Zhao, Chunjuan Zhang, 2008 .

Immunomodulatory Effects of Erythromycin and its Derivatives on Human T-Lymphocyte In Vitro

Lan Wu, Kai Bao, Jie Lin, 2007, Immunopharmacology and immunotoxicology.

Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.

Xin A. Zhang, Daiying Zuo, Qi Guan, 2022, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents

Dongming Xing, Qi Guan, Weige Zhang, 2021, Journal of enzyme inhibition and medicinal chemistry.

Direct cycle between co-product and reactant: an approach to improve the atom economy and its application in the synthesis and protection of primary amines

Kai Bao, Qi Guan, Weige Zhang, 2016 .

Conformation impacts on the bioactivities of SMART analogues.

Kai Bao, Daiying Zuo, Qi Guan, 2018, European journal of medicinal chemistry.

Synthesis and Anti‐proliferative in‐vitro Activity of Two Natural Dihydrostilbenes and their Analogues

X. Yao, Yingliang Wu, Dai-lin Liu, 2007, Archiv der Pharmazie.

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities.

Kai Bao, Daiying Zuo, Zengqiang Li, 2014, European journal of medicinal chemistry.

Design, synthesis and bioevaluation of antitubulin agents carrying diaryl-5,5-fused-heterocycle scaffold.

Kai Bao, Daiying Zuo, Yingliang Wu, 2017, European journal of medicinal chemistry.

A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents.

M. Cheng, Kai Bao, Weige Zhang, 2008, Chemical communications.

Total synthesis and RXRα-mediated transcription studies of neriifolone B and related compounds.

Guanghui Wang, X. Yao, Haifeng Chen, 2014, Bioorganic & medicinal chemistry.

Synthesis of (±) homoisoflavanone and corresponding homoisoflavane

X. Yao, Kai Bao, Yi Dai, 2008, Journal of Asian natural products research.

Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues

Xiaona Li, Kai Bao, Daiying Zuo, 2016, Scientific Reports.

Overcoming resistance to mitochondrial apoptosis by BZML‐induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells

Daiying Zuo, Yingliang Wu, Xiaobo Xu, 2018, Cell proliferation.

MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2020, Chemico-biological interactions.

Synthesis and antiproliferative activity of novel erythromycin derivatives

Kai Bao, Yingliang Wu, L. Long, 2010 .

Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification.

M. Cheng, Kai Bao, Xiang Zhao, 2007, Molecules.

Synthesis and Antiproliferative In‐Vitro Activity of Natural Flavans and Related Compounds

Kai Bao, Xiaolong Wang, Weige Zhang, 2007, Archiv der Pharmazie.

Magnetic magnetite nanoparticals catalyzed selective oxidation of α-hydroxy ketones with air and one-pot synthesis of benzilic acid and phenytoin derivatives

Xiaona Li, D. Xia, Kai Bao, 2018, Molecular Catalysis.

YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles.

Kai Bao, Daiying Zuo, Yingliang Wu, 2020, Bioorganic chemistry.

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors

Kai Bao, Daiying Zuo, Yingliang Wu, 2017, Scientific Reports.

Application of an ultra-performance liquid chromatography method with tandem mass spectrometry to pharmacokinetics, tissue distribution and excretion in the study of DAT-230, a novel tubulin-binding agent candidate, in rats.

Longshan Zhao, Xiaohui Chen, Chungang Zhang, 2015, Journal of pharmaceutical and biomedical analysis.

The total synthesis of D-chalcose and its C-3 epimer

Kai Bao, Weige Zhang, Jun Sun, 2013, Beilstein journal of organic chemistry.

Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization.

Kai Bao, Daiying Zuo, Yingliang Wu, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

Kai Bao, Daiying Zuo, Zi Liu, 2021, Journal of enzyme inhibition and medicinal chemistry.

3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: microwave-assisted synthesis and biological evaluation.

Kai Bao, Zhaoshi Bai, Weige Zhang, 2015, European journal of medicinal chemistry.

Synthesis and Biological Evaluations of 1,2‐Diaryl Pyrroles as Analogues of Combretastatin A‐4

Chunjian Liu, Kai Bao, Daiying Zuo, 2015, Chemical biology & drug design.

DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080

Xueqi Shen, Daiying Zuo, Yingliang Wu, 2012, Cancer Chemotherapy and Pharmacology.

Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors.

Kai Bao, Qi Guan, Weige Zhang, 2019, Bioorganic & Medicinal Chemistry.

Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.

Lijie Wang, Kai Bao, Qi Guan, 2014, European journal of medicinal chemistry.

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061), a novel microtubule inhibitor, evokes G2/M cell cycle arrest and apoptosis in human breast cancer cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2015, Chemico-biological interactions.

Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell

T. Ikejima, S. Onodera, S. Tashiro, 2006, Acta Pharmacologica Sinica.

BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe.

Daiying Zuo, Yingliang Wu, Qi Guan, 2017, Cancer letters.

Activated carbon/Brønsted acid-promoted aerobic benzylic oxidation under "on-water" condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors.

Kai Bao, Kai Zhou, Qi Guan, 2019, European journal of medicinal chemistry.

Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells

Wen Bin, Lan Wu, Weiyun Wang, 2016, PLoS ONE.

In vitro effects of erythromycin on RANKL and nuclear factor-kappa B by human TNF-alpha stimulated Jurkat cells.

Lan Wu, Peng Li, Kai Bao, 2009, International immunopharmacology.

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2018, Cancer biology & therapy.

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2016, Cancer letters.

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers

Daiying Zuo, Zi Liu, Zengqiang Li, 2022, The Journal of biological chemistry.

Chalcogen bond-assisted syn-locked scaffolds: DFT analysis and biological implications of novel tubulin inhibitors.

Yukun Yang, Qi Guan, Weige Zhang, 2022, Biochemical and biophysical research communications.

Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.

Zhenpeng Guo, Qi Guan, Weige Zhang, 2021, Bioorganic chemistry (Print).

1-(3',4',5'-Trimethoxyphenyl)-3-(3'',4''-dimethoxy-2''-hydroxyphenyl)-propane with microtubule-depolymerizing ability induces G2/M phase arrest and apoptosis in HepG2 cells.

Enlong Ma, Yanchun Li, Jian-chun Li, 2010, Chemico-biological interactions.

The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-D-glucose.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2022, Chemico-biological interactions.

Correction to: YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors.

Na Li, Qi Guan, Weige Zhang, 2023, European journal of medicinal chemistry.

2‐Methoxy‐5((3,4,5‐trimethosyphenyl) seleninyl) phenol causes G2/M cell cycle arrest and apoptosis in NSCLC cells through mitochondrial apoptotic pathway and MDM2 inhibition

Bolin Liu, Jiang Bian, Daiying Zuo, 2022, Journal of biochemical and molecular toxicology.

Activated carbon for aerobic oxidation: Benign approach toward 2-benzoylbenzimidazoles and 2-benzoylbenzoxazoles synthesis

Kai Bao, Fuhai Li, Weige Zhang, 2015, Scientific Reports.

Microwave-assisted synthesis, molecular docking and antiproliferative activity of (3/5-aryl-1,2,4-oxadiazole-5/3-yl)(3,4,5-trimethoxyphenyl)methanone oxime derivatives

Kai Bao, Daiying Zuo, Yingliang Wu, 2015 .

Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors.

Kai Bao, Qi Guan, Weige Zhang, 2018, European journal of medicinal chemistry.

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.

Lingman Ma, Qi Guan, Zhaoshi Bai, 2020, Chemico-biological interactions.

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.

Daiying Zuo, Zengqiang Li, Yingliang Wu, 2020, Chemico-biological interactions.