B. Subramanyam

发表

Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.

M. Adler, M. Whitlow, M. Morrissey, 2007, Bioorganic & medicinal chemistry.

A novel P2Y12 adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models

C. Mallari, R. Vergona, W. Dole, 2007, Thrombosis and Haemostasis.

Fasudil , a Rho -

M. Halks-Miller, Xiangru Lu, Q. Feng, 2005 .

Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis

M. Halks-Miller, Xiangru Lu, Q. Feng, 2005, Circulation.

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets.

J. Morser, I. Islam, Shendong Yuan, 2008, Thrombosis research.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.

M. Adler, M. Whitlow, R. Feldman, 2007, Bioorganic & medicinal chemistry letters.

Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase.

K. Reynolds, Z. Yuan, P. Callery, 1992, Chemico-biological interactions.

Hepatocyte clearance and pharmacokinetics of recombinant factor IX glycosylation variants.

E. Blasko, E. Ho, James M. Wu, 2013, Biochemical and biophysical research communications.

Identification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1*

D. Taub, S. Harvey, R. Horuk, 2000, The Journal of Biological Chemistry.

Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo.

A. Schottelius, D. Davey, C. Mallari, 2004, Journal of medicinal chemistry.

Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process.

Wei Xu, M. Morrissey, I. Islam, 2018, Bioorganic & medicinal chemistry letters.

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization.

R. Vergona, W. Dole, J. Morser, 2008, Thrombosis research.

Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidol.

H. Whiteford, D. Eyles, S. Pond, 1991, Biochemical and Biophysical Research Communications - BBRC.

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats.

H. Rollema, T. Woolf, B. Subramanyam, 1990, Biochemical and biophysical research communications.

CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.

D. Davey, G. Phillips, J. Onuffer, 2007, Bioorganic & medicinal chemistry letters.

Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors

N. Sarapa, H. Dinter, B. Subramanyam, 2016, Clinical cancer drugs.

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

M. Whitlow, D. Davey, K. Eagen, 1998, Journal of medicinal chemistry.

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.

John E. Murphy, C. Pan, H. Tjandra, 2010, Blood.

Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.

Bin Ye, David Light, Marc Adler, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.

K. Eagen, M. Morrissey, G. Phillips, 2002, Bioorganic & medicinal chemistry.

Conformational and dielectric analysis of hydrogen bonded polar binary mixtures of methyl benzoate with N-methylaniline

V. Murthy, M. Chitra, B. Subramanyam, 2001 .

Lipoxins and novel 15‐epi‐lipoxin analogs display potent anti‐inflammatory actions after oral administration

C. Serhan, K. Gronert, P. Devchand, 2004, British journal of pharmacology.

A cyclic imine intermediate in the in vitro metabolic conversion of 1,6-diaminohexane to 6-aminohexanoic acid and caprolactam.

M. Egorin, P. Callery, L. Geelhaar, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Involvement of monoamine oxidase and diamine oxidase in the metabolism of the cell differentiating agent hexamethylene bisacetamide (HMBA).

B. Conley, M. Egorin, P. Callery, 1988, Life sciences.

The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide

B. Conley, M. Egorin, C. Grieshaber, 2004, Cancer Chemotherapy and Pharmacology.

Alkylamides as inducers of human leukemia cell differentiation: a quantitative structure-activity relationship study using comparative molecular field analysis.

M. Egorin, P. Callery, B. Subramanyam, 1993, Cancer Research.

Metabolism of hexamethylene bisacetamide and its metabolites in leukemic cells.

E. Zuhowski, M. Egorin, P. Callery, 1988, Cancer research.

Anti‐tumor efficacy of the nucleoside analog 1‐(2‐deoxy‐2‐fluoro‐4‐thio‐β‐D‐arabinofuranosyl) cytosine (4′‐thio‐FAC) in human pancreatic and ovarian tumor xenograft models

J. Hoffmann, E. Ho, H. Dinter, 2005, International journal of cancer.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

M. Adler, M. Whitlow, R. Feldman, 2007, Bioorganic & medicinal chemistry letters.

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite.

N. Castagnoli, T. Woolf, B. Subramanyam, 1991, Chemical research in toxicology.

MONITORING MOLECULES IN NEUROSCIENCE

Babu Subramanyam, H. Rollema, H Rollema, 1991 .

A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) – Part I: Pharmacological characterization

R. Vergona, M. Nagashima, J. Morser, 2006, Thrombosis and Haemostasis.

Measurements of drug-protein binding by using immobilized human serum albumin liquid chromatography-mass spectrometry.

E. Ho, B. Subramanyam, J. Tseng, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Differential Inhibition of Inducible T Cell Cytokine Secretion by Potent Iron Chelators

Hong-tao Lu, M. Berger, D. Schilling, 2005, Journal of biomolecular screening.

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.

M. Adler, M. Whitlow, M. Ohlmeyer, 2007, Journal of medicinal chemistry.

An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.

B. Conley, M. Egorin, P. Callery, 1989, Drug metabolism and disposition: the biological fate of chemicals.