T. Kaitu'u-Lino

J. Galaz, M. Varas-Godoy, S. Illanes, 2017, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR.

N. Hannan, R. Hiscock, S. Tong, 2014, Placenta.

MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin

S. Tong, T. Kaitu'u-Lino, L. Tuohey, 2012, PloS one.

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)–Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms–Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction: Potential Therapeutic for Preeclampsia

N. Hannan, S. Tong, N. Binder, 2015, Hypertension.

Identification of Label-Retaining Perivascular Cells in a Mouse Model of Endometrial Decidualization, Breakdown, and Repair1

C. Gargett, L. Salamonsen, J. Girling, 2012, Biology of reproduction.

Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage.

S. Tong, T. Kaitu'u-Lino, L. Tuohey, 2012, Journal of reproductive immunology.

Placental SEMA3B expression is not altered in severe early onset preeclampsia.

N. Hannan, S. Tong, N. Binder, 2014, Placenta.

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2015, Molecular and Cellular Endocrinology.

The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women.

I. Fraser, L. Salamonsen, T. Kaitu'u-Lino, 2007, Reproduction.

Plasma MIC-1 and PAPP-A Levels Are Decreased among Women Presenting to an Early Pregnancy Assessment Unit, Have Fetal Viability Confirmed but Later Miscarry

R. Hiscock, S. Tong, J. Konje, 2013, PloS one.

Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model.

L. Salamonsen, T. Kaitu'u-Lino, Naomi B. Morison, 2007, Endocrinology.

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

L. Parry, N. Hannan, Sevvandi N. Senadheera, 2019, EBioMedicine.

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

L. Gordon, S. Walker, C. Whitehead, 2015, Reproductive Sciences.

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2016, Pregnancy hypertension.

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia.

C. Whitehead, N. Hannan, S. Tong, 2018, Pregnancy hypertension.

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia.

P. Fuller, C. Whitehead, N. Hannan, 2016, Placenta.

Clinical tools and biomarkers to predict preeclampsia

S. Walker, N. Hannan, T. MacDonald, 2021, EBioMedicine.

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2020, Pregnancy hypertension.

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia.

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2020, Placenta.

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2018, Pregnancy hypertension.

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, PloS one.

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta.

N. Hannan, M. Deo, S. Tong, 2016, Placenta.

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2016, BMC Pregnancy and Childbirth.

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

C. Whitehead, N. Hannan, S. Tong, 2015, Hypertension.

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin.

N. Hannan, S. Tong, Sally Beard, 2014, Pregnancy hypertension.

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin.

M. Lappas, E. Williams, C. Whitehead, 2012, The American journal of pathology.

Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries—A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development

N. Hannan, S. Tong, N. Binder, 2022, International journal of molecular sciences.

Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease

N. Hannan, N. Binder, Sally Beard, 2022, International journal of molecular sciences.

Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

L. Bergman, C. Cluver, S. Walker, 2022, Journal of the American Heart Association.

Placental DAAM2 is unaltered in preeclampsia, but upregulated by treatment with proton pump inhibitors.

N. Hannan, S. Tong, N. Binder, 2022, Pregnancy hypertension.

Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction

C. Cluver, S. Walker, N. Hannan, 2022, Journal of clinical medicine.

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction.

N. Hannan, S. Tong, N. Binder, 2020, Pregnancy hypertension.

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

B. Mol, C. Cluver, S. Walker, 2019, BMJ Open.

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

A. Shub, T. Johns, N. Hannan, 2015, Hypertension.

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health

N. Hannan, N. Binder, Sally Beard, 2022, Life Science Alliance.

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia.

Tuong-Vi Nguyen, J. Myers, S. Walker, 2021, Placenta.

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment

Tuong-Vi Nguyen, N. Hannan, M. Deo, 2017, Scientific Reports.

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

M. Ikawa, L. Parry, Masanaga Muto, 2017, Hypertension.

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14.

H. Nguyen, N. Hannan, S. Tong, 2015, Placenta.

Peptides do not prevent cleavage of endoglin to produce soluble endoglin.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2014, Pregnancy hypertension.

PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia.

M. Gantier, S. Tong, T. Kaitu'u-Lino, 2014, Reproduction, fertility, and development.

PSG7 and 9 (Pregnancy‐Specific β‐1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

J. Myers, L. Bergman, C. Cluver, 2022, Journal of the American Heart Association.

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Scientific Reports.

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2018, Pregnancy hypertension.

The effect of metformin on cardiovascular markers in female mice consuming a high fat diet.

N. Hannan, N. Binder, Sally Beard, 2022, Obesity research & clinical practice.

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.

Qi Chen, N. Hannan, S. Tong, 2017, Placenta.

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.

K. Schindler, N. Hannan, S. Tong, 2020, Placenta.

Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse.

Rebecca L. Jones, L. Salamonsen, G. Nie, 2006, Reproduction.

Placental galectin-3 is reduced in early-onset preeclampsia

N. Hannan, T. MacDonald, S. Tong, 2022, Frontiers in Physiology.

Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro.

P. Stanton, T. Kaitu'u-Lino, P. Sluka, 2007, Reproduction.

Expression of Myostatin in Intrauterine Growth Restriction and Preeclampsia Complicated Pregnancies and Alterations to Cytokine Production by First-Trimester Placental Explants Following Myostatin Treatment

K. Vaswani, M. Mitchell, G. Rice, 2015, Reproductive Sciences.

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

S. Brennecke, L. Hui, S. Walker, 2018, BMC Pregnancy and Childbirth.

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production1

N. Hannan, S. Illanes, S. Tong, 2016, Biology of reproduction.

Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss

M. Permezel, C. Whitehead, S. Tong, 2012, PloS one.

A wash step at collection of placental biopsies from preeclamptic pregnancies does not adversely affect levels of sFlt-1 or endoglin.

N. Hannan, S. Tong, N. Binder, 2015, Pregnancy hypertension.

Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction

N. Hannan, T. MacDonald, S. Tong, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A new role for activin in endometrial repair after menses.

D. Phillips, L. Salamonsen, T. Kaitu'u-Lino, 2009, Endocrinology.

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

J. Myers, S. Walker, N. Hannan, 2021, Scientific Reports.

Measuring circulating miRNAs in early pregnancy could identify fetuses’ destined to undergrow and be at increased risk of stillbirth

S. Tong, T. Kaitu'u-Lino, 2020, EBioMedicine.

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

L. Hui, Tuong-Vi Nguyen, J. Myers, 2020, Nature Communications.

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin.

L. Hui, S. Walker, N. Hannan, 2020, Placenta.

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.

Helen C McNamara, P. Fuller, S. Walker, 2016, American journal of obstetrics and gynecology.

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

S. Walker, N. Hannan, T. MacDonald, 2019, Placenta.

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

N. Hannan, S. Seeho, K. Groom, 2021, Scientific Reports.

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

S. Kane, L. Hui, S. Walker, 2021, Scientific reports.

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia.

S. Walker, N. Hannan, T. MacDonald, 2019, Placenta.

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2020, Scientific Reports.

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Scientific Reports.

Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study

M. Lappas, M. Permezel, R. Hoermann, 2013, Reproductive Biology and Endocrinology.

Extracellular Matrix Dynamics in Scar-Free Endometrial Repair: Perspectives from Mouse In Vivo and Human In Vitro Studies1

L. Salamonsen, T. Kaitu'u-Lino, Jemma Evans, 2011, Biology of reproduction.

Pravastatin, proton pump inhibitors, metformin, micronutrients and biologics: new horizons for the prevention or treatment of preeclampsia.

C. Cluver, N. Hannan, S. Tong, 2020, American journal of obstetrics and gynecology.

A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants.

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2021, Placenta.

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion

N. Hannan, S. Tong, Sally Beard, 2019, Hypertension.

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2017, Reproductive Sciences.

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

S. Tong, T. Kaitu'u-Lino, K. Palmer, 2016, Molecular human reproduction.

NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast

S. Kane, S. Walker, N. Hannan, 2021, Scientific Reports.

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

S. Kane, N. Hannan, S. Seeho, 2022, Antioxidants.

Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction.

Stephen Tong, M. Lappas, S. Walker, 2013, The Journal of clinical endocrinology and metabolism.

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction – implications for treating preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, PloS one.

Circulating trace elements for the prediction of preeclampsia and small for gestational age babies

A. Perkins, T. MacDonald, S. Tong, 2021, Metabolomics.

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

N. Hannan, T. MacDonald, S. Tong, 2021, Journal of clinical medicine.

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction.

Y. Li, Mingzhi Zhao, G. Nie, 2015, The Journal of clinical endocrinology and metabolism.

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia.

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Pregnancy hypertension.

Stimulation of epithelial repair is a likely mechanism for the action of mifepristone in reducing duration of bleeding in users of progestogen-only contraceptives.

I. Fraser, L. Salamonsen, T. Kaitu'u-Lino, 2008, Reproduction.

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

L. Parry, N. Hannan, Sevvandi N. Senadheera, 2016, American journal of obstetrics and gynecology.

Screening circulating proteins to identify biomarkers of fetal macrosomia

Tuong-Vi Nguyen, S. Walker, T. MacDonald, 2019, BMC Research Notes.

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

D. Charnock-Jones, Sungsam Gong, Gordon C. S. Smith, 2018, The American journal of pathology.

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

A. Chand, C. Whitehead, N. Hannan, 2017, Hypertension.

ATF3 is a negative regulator of inflammation in human fetal membranes.

M. Lappas, R. Lim, S. Liong, 2016, Placenta.

Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia

N. Hannan, N. Binder, Sally Beard, 2023, International journal of molecular sciences.

A Bioplex Analysis of Cytokines and Chemokines in First Trimester Maternal Plasma to Screen for Predictors of Miscarriage

N. Hannan, S. Tong, J. Konje, 2014, PloS one.

Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model.

N. Hannan, N. Binder, Sally Beard, 2023, Placenta.

Placental growth factor is negatively regulated by epidermal growth factor receptor (EGFR) signaling.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2021, Placenta.

Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial

C. Cluver, S. Walker, R. Hiscock, 2021, BMJ.

Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia

N. Hannan, N. Binder, Sally Beard, 2022, International journal of molecular sciences.

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies.

T. Johns, A. Horne, J. Macdiarmid, 2013, Endocrinology.

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study.

P. Gluckman, K. Godfrey, J. Eriksson, 2021, Placenta.

Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

A. Horne, S. Tong, T. Kaitu'u-Lino, 2013, PloS one.

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction

Tuong-Vi Nguyen, J. Myers, S. Walker, 2021, International journal of molecular sciences.

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth.

N. Hannan, N. Binder, T. Kaitu'u-Lino, 2022, Reproduction.

Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2023, Placenta.

Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2023, Reproductive Biology and Endocrinology.

Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth

A. Hayes, Danielle A. Debruin, N. Hannan, 2023, Scientific Reports.

Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth

T. Johns, A. Horne, C. Whitehead, 2013, Obstetrics and gynecology.

Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

A. Horne, S. Tong, T. Kaitu'u-Lino, 2012, PloS one.

Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant

B. Nijagal, T. MacDonald, S. Tong, 2023, EBioMedicine.

Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?

C. Gray, R. Dechend, L. Bergman, 2023, Journal of reproductive immunology.

293. Preclinical assessment of new generation antiplatelet therapies to prevent preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, Pregnancy Hypertension.

[261-POS]: Heme oxygenase-1 is not reduced in pre-eclampsia and does not regulate sFlt-1 or soluble endoglin production.

C. Cluver, C. Whitehead, N. Hannan, 2015 .

Reepithelialization of the uterine surface arises from endometrial glands: evidence from a functional mouse model of breakdown and repair.

C. Gargett, T. Kaitu'u-Lino, L. Ye, 2010, Endocrinology.