M. Constância

发表

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia.

Gusztav Belteki, D. Dunger, A. Prentice, 2012, Human molecular genetics.

Regulation of placental efficiency for nutrient transport by imprinted genes.

B. Tycko, I. Sandovici, W. Reik, 2006, Placenta.

Igf2 imprinting in development and disease.

W. Reik, A. Murrell, G. Kelsey, 2000, The International journal of developmental biology.

Placental-specific IGF-II is a major modulator of placental and fetal growth

W. Reik, C. Sibley, A. Ferguson-Smith, 2002, Nature.

Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.

W. Reik, C. Sibley, A. Ferguson-Smith, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2‐mediated overgrowth

I. Sandovici, W. Reik, C. Sibley, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver

G. Yeo, S. Ozanne, W. Cooper, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Programming placental nutrient transport capacity

A. Fowden, A. Forhead, M. Constância, 2006, The Journal of physiology.

Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport

C. Sibley, J. Glazier, M. Dilworth, 2010, Proceedings of the National Academy of Sciences.

Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse

C. Sibley, A. Ferguson-Smith, G. Burton, 2008, The Journal of physiology.

Maternal to offspring resource allocation in plants and mammals.

G. Burton, J. Gutierrez-Marcos, M. Constância, 2012, Placenta.

Maternal-fetal resource allocation.

M. Constância, A. Fowden, 2012, Placenta.

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

I. Sandovici, F. Pezzella, A. Hassan, 2012, EMBO molecular medicine.

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

I. Sandovici, C. Lien, H. Sucov, 2015, Cardiovascular research.

Proliferation and growth factor expression in abnormally enlarged placentas of mouse interspecific hybrids

M. Hemberger, H. Hameister, I. Dragatsis, 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

lgf 2 imprinting 145 Igf 2 imprinting in development and disease

W. Reik, A. Murrell, G. Kelsey, 2000 .

Imprinted genes and the epigenetic regulation of placental phenotype.

G. Burton, A. Fowden, M. Constância, 2011, Progress in biophysics and molecular biology.

Sex differences in the intergenerational inheritance of metabolic traits

I. Sandovici, S. Ozanne, D. Fernandez‐Twinn, 2022, Nature Metabolism.

Dietary composition programmes placental phenotype in mice

G. Burton, P. M. Coan, M. Constância, 2011, The Journal of physiology.

Epigenetics and imprinting of the trophoblast -- a workshop report.

A. Ferguson-Smith, G. Kelsey, M. Hemberger, 2006, Placenta.

Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.

W. Reik, K. Ohta, H. Sasaki, 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

The imprinted Mir483 is a growth suppressor and metabolic regulator functioning through IGF1

K. Siddle, I. Sandovici, H. Prosser, 2022, bioRxiv.

Placental-specific Igf-2 regulates the diffusional exchange characteristics of the mouse placenta

W. Reik, C. Sibley, A. Ferguson-Smith, 2004 .

Contribution of Placental Genomic Imprinting and Identification of Imprinted Genes

I. Sandovici, W. Cooper, M. Constância, 2014 .

Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta.

I. Sandovici, P. Arck, G. Leone, 2019, American journal of physiology. Endocrinology and metabolism.

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

A. Fowden, J. López-Tello, A. Sferruzzi-Perri, 2016, Proceedings of the National Academy of Sciences.

The placenta and fetal programming

G. Burton, A. Forhead, P. M. Coan, 2007 .

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

I. Sandovici, S. Ozanne, Constanze M Hammerle, 2013, Cellular and Molecular Life Sciences.

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

A. Wood, D. Charnock-Jones, U. Sovio, 2018, JCI insight.

Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta

D. Charnock-Jones, U. Sovio, Sungsam Gong, 2018, Epigenetics.

Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.

G. Burton, M. Suciu, A. Fowden, 2011, Endocrinology.

Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis.

R. Seruca, M. Sobrinho-Simões, N. R. dos Santos, 1996, Gastroenterology.

Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review

I. Sandovici, S. Andrade, T. Morais, 2021, Frontiers in Endocrinology.

Child health, developmental plasticity, and epigenetic programming.

M. Fraga, C. Junien, R. Scharfmann, 2011, Endocrine reviews.

An intragenic methylated region in the imprinted Igf2 gene augments transcription

W. Reik, A. Murrell, G. Kelsey, 2001, EMBO reports.

An upstream repressor element plays a role in Igf2 imprinting

W. Reik, H. Cedar, I. Keshet, 2001, The EMBO journal.

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

I. Sandovici, S. Levison, T. Wood, 2019, Stem cell reports.

Genomic Imprinting at the Transcriptional Level

W. Reik, A. Murrell, M. Constância, 2006 .

Placental efficiency and adaptation: endocrine regulation

G. Burton, M. Constância, A. Fowden, 2009, The Journal of physiology.

How genome-wide approaches can be used to unravel the remaining secrets of the imprintome.

W. Cooper, M. Constância, 2010, Briefings in functional genomics.

Imprinted Genes, Placental Development and Fetal Growth

W. Reik, C. Sibley, A. Fowden, 2006, Hormone Research in Paediatrics.

Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming.

I. Sandovici, M. Constância, E. Angiolini, 2012, Reproductive biomedicine online.

Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice

G. Burton, A. Fowden, M. Constância, 2010, The Journal of physiology.

Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice

I. Sandovici, G. Burton, A. Fowden, 2008, The Journal of physiology.

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.

I. Sandovici, W. Reik, C. Sibley, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Resourceful imprinting

Wolf Reik, Gavin Kelsey, W. Reik, 2004, Nature.

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

Wendy Dean, Benjamin Tycko, Wolf Reik, 2003, The Journal of physiology.

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

W. Reik, G. Kelsey, W. Dean, 2000, Nature Genetics.

Maternal diet and aging alter the epigenetic control of a promoter–enhancer interaction at the Hnf4a gene in rat pancreatic islets

Yoko Ito, Yoko Ito, C. Ling, 2011, Proceedings of the National Academy of Sciences.

11β-Hydroxysteroid Dehydrogenases in the Regulation of Tissue Glucocorticoid Availability

R. Monteiro, M. Constância, C. Pereira, 2012 .

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

I. Sandovici, S. Andrews, G. Yeo, 2015, Diabetologia.

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.

T. Moore, W. Reik, H. Sasaki, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

I. Sandovici, G. Burton, G. Yeo, 2019, bioRxiv.

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions.

W. Reik, J. Walter, A. Murrell, 2003, Human molecular genetics.

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

S Apostolidou, P Stanier, D Monk, 2006, Human molecular genetics.

Retinoblastoma gene structure and product expression in human gastric carcinomas.

R. Seruca, S. Castedo, F. Carneiro, 1994, British Journal of Cancer.

Fetus-derived IGF2 matches placental development to fetal demand

I. Sandovici, G. Burton, G. Yeo, 2019 .

Imprinting mechanisms.

B. Pickard, W. Reik, G. Kelsey, 1998, Genome research.

Resourceful imprinting : Fertility

Gavin Kelsey, G. Kelsey, M. Constância, 2004 .

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

D. Dunger, K. Ong, W. Lowe, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region

K. Mitsuya, W. Reik, A. Lewis, 2004, Molecular and Cellular Biology.

Region Igf 2H 19 Imprinting in the Has No Effect on H 19 Element Upstream of Deletion of a Conserved Direct Repeat Tandem Repeat Hypothesis in Imprinting :

K. Mitsuya, W. Reik, A. Lewis, 2004 .

Intergenerational epigenetic inheritance in models of developmental programming of adult disease.

S. Ozanne, D. Fernandez‐Twinn, M. Constância, 2015, Seminars in cell & developmental biology.

Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

I. Sandovici, M. Hemberger, B. Lam, 2019, eLife.

Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus

I. Sandovici, M. Hemberger, W. Cooper, 2018, bioRxiv.

Placental programming of anxiety in adulthood revealed by Igf2-null models

L. Wilkinson, T. Humby, M. Constância, 2013, Nature Communications.

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

I. Sandovici, A. Fowden, A. Sferruzzi-Perri, 2017, The Journal of physiology.

to the 1 growing fetus 2

M. Hemberger, J. López-Tello, A. Sferruzzi-Perri, 2018 .

Genomic imprinting: Making sense or antisense?

Wolf Reik, W. Reik, Miguel Constancia, 1997, Nature.

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function

I. Sandovici, H. Prosser, S. Ozanne, 2020, PLoS genetics.

Mesenchymal Igf2 is a major paracrine regulator of pancreatic growth and function

I. Sandovici, H. Prosser, S. Ozanne, 2019, bioRxiv.

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial

D. Dunger, A. Prentice, K. Ong, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanisms of Disease: the developmental origins of disease and the role of the epigenotype

S. Ozanne, M. Constância, 2007, Nature Clinical Practice Endocrinology &Metabolism.

An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory

A. Ferguson-Smith, G. Burton, A. Fowden, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19Δ13

D. Dunger, W. Reik, K. Ong, 2009, Diabetes.

Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE

I. Sandovici, C. Calhau, L. Correia-Sá, 2017, Scientific Reports.

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

I. Sandovici, A. Ferguson-Smith, A. Ward, 2015, Nature Communications.

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

I. Sandovici, C. Sibley, G. Burton, 2021, Genes.

Maternal diet, aging and diabetes meet at a chromatin loop

I. Sandovici, S. Ozanne, M. Constância, 2011, Aging.

LRRK 2 regulates mitochondrial dynamics and function through direct interaction with DLP 1

Y. Gilad, A. Prentice, F. Zhou, 2012 .

Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile

R. Lothe, P. Peltomäki, R. Seruca, 1995, International journal of cancer.

Genome-wide analysis of promoter contacts identifies novel regulators of late-stage adipogenesis

S. O’Rahilly, I. Sandovici, P. Fraser, 2023, bioRxiv.

Increased Placental Glucose Transport Rates in Pregnant Mice Carrying Fetuses with Targeted Disruption of Their Placental-Specific Igf2 Transcripts Are Not Associated with Raised Circulating Glucose Concentrations

D. Dunger, W. Reik, K. Ong, 2011, Experimental diabetes research.

Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.

I. Sandovici, G. Yeo, B. Lam, 2023, Cell metabolism.

Protocol to isolate and culture primary mouse feto-placental endothelial cells

I. Sandovici, M. Constância, Moritz Reiterer, 2022, STAR protocols.

Intergenerational epigenetic inheritance in models of developmental programming of adult disease.

S. Ozanne, D. Fernandez‐Twinn, M. Constância, 2015, Seminars in cell & developmental biology.

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

I. Sandovici, S. Ozanne, Constanze M Hammerle, 2013, Cellular and Molecular Life Sciences.

Imprinted genes and the coordination of fetal and postnatal growth in mammals.

K. Davies, W. Reik, G. Kelsey, 2001, Novartis Foundation symposium.

Maternal diet, aging and diabetes meet at a chromatin loop

I. Sandovici, S. Ozanne, M. Constância, 2011, Aging.

Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand

I. Sandovici, S. Ozanne, A. Vidal-Puig, 2021, Scientific Reports.