S. Klutchko

发表

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.

R. W. Fleming, C. J. Blankley, A. Essenburg, 1986, Journal of medicinal chemistry.

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.

R. B. Parker, A. Essenburg, S. Klutchko, 1981, Journal of medicinal chemistry.

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.

P. Ellis, W. Denny, A. Bridges, 2006, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

C. J. Blankley, J. C. Hodges, J. Quin, 1991, Journal of medicinal chemistry.

Heterocyclic syntheses with β-ketosulfoxides. II. New syntheses of 4-hydroxyquinolines, quinolones and cinnolinones

J. Shavel, S. Klutchko, M. V. Strandtmann, 1972 .

Amino Derivatives of Pyrazine N-Oxides1

S. Klutchko, S. Lazarus, R. Meltzer, 1964 .

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

A. Doherty, H. W. Hamilton, B. Steinbaugh, 1992, Journal of medicinal chemistry.

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.

D. Boschelli, A. Doherty, H. D. Showalter, 1998, Journal of medicinal chemistry.

Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams with Carbon Nucleophiles

J. M. Hamby, M. Reily, M. Taylor, 1993 .

4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine‐6‐carboxylic acids (spinacines)

C. J. Blankley, J. C. Hodges, S. Klutchko, 1991 .

Synthesis of Amino 1,3-Diols, e.g. (V) - (VIII). Ring Opening of N- Acyl Activated Lactams, e.g. (I), with Carbon Nucleophiles, e.g. (II), (XI).

J. M. Hamby, M. Reily, M. Taylor, 1993 .

Stereospecific Synthesis of S,S-Statine and its Congeners

J. C. Hodges, S. Klutchko, P. O'brien, 1989 .

Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.

D. Boschelli, A. Doherty, H. D. Showalter, 1998, Journal of medicinal chemistry.

Heterocyclic synthesis with β‐ketosulfoxides IV. Synthesis of 3‐substituted chromones

J. Shavel, S. Klutchko, M. V. Strandtmann, 1974 .

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

J. M. Hamby, R. Panek, J. C. Hodges, 1995, Journal of medicinal chemistry.

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.

A. Doherty, J. M. Hamby, R. Panek, 1997, The Journal of pharmacology and experimental therapeutics.

Heterocyclic syntheses with β‐ketosulfoxides. I. New syntheses of chromones, flavones, thioindigo and thioflavones

J. Shavel, S. Klutchko, M. V. Strandtmann, 1972 .

Isomerism in the Direct Chlorination of 2-Methylpyrazine1a

S. Klutchko, S. Lazarus, R. Meltzer, 1964 .

4,7-Diazaindole Derivatives

S. Klutchko, R. Meltzer, H. Hansen, 1965 .

Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity

J. C. Hodges, S. Klutchko, J. Hamby, 1994 .

2-Substituted Aminopyrido[2,3- d ]pyrimidin-7(8 H )-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

D. Boschelli, A. Doherty, H. D. Showalter, 1998 .

Base rearrangement of chromone-3-carboxylic esters to 3-acyl-4-hydroxycoumarins

J. Shavel, S. Klutchko, M. V. Strandtmann, 1974 .

Reaction of enamines with o-hydroxy-.omega.-nitrostyrenes. Preparation of benzodihydropyans and hexahydroxanthenes and their rearrangement to pyrroline 1-oxides and hexahydroindole 1-oxides

J. Shavel, S. Klutchko, Arch C. Sonntag, 1973 .

CHEMISTRY AND PHARMACOLOGY OF MONOAMINE OXIDASE INHIBITORS: HYDRAZINE DERIVATIVES.

S. Klutchko, J. Gylys, W. Cetenko, 1962, Journal of medicinal and pharmaceutical chemistry.