N. Kim

发表

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Jared L. Johnson, P. Sorger, N. Gray, 2019, Cell chemical biology.

Discovery and Development of Anti-HBV Agents and Their Resistance

B. Seong, Kyun-Hwan Kim, N. Kim, 2010, Molecules.

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.

Young Hoon Kim, Dae-Yeul Yu, Kyoung Tai No, 2010, Bioorganic & medicinal chemistry.

DPIE [2-(1,2-diphenyl-1H-indol-3-yl)ethanamine] Augments Pro-Inflammatory Cytokine Production in IL-1β-Stimulated Primary Human Oral Cells

Tae-Hoon Lee, K. Chay, Sun-Hee Ahn, 2018, International journal of molecular sciences.

A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities.

Y. N. Park, K. Song, Sung-Kyun Ko, 2015, Chemistry & biology.

Anti-Cancer Effect of Thiacremonone through Down Regulation of Peroxiredoxin 6

J. Hong, Dong Hun Lee, Mi Kyeong Lee, 2014, PloS one.

Crystal structure of hyperthermophilic esterase EstE1 and the relationship between its dimerization and thermostability properties

Hyun-soo Cho, J. Byun, Dong-Uk Kim, 2007, BMC Structural Biology.

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-N-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Sang-Hyun Min, Tae-Hoon Lee, Sun-Hee Ahn, 2018, Molecules.

Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling

H. Choi, Eunhwa Ko, Joon-Suk Park, 2016, Oncotarget.

High-throughput profiling of peptide-RNA interactions using peptide microarrays.

Jaehoon Yu, I. Shin, Im-Soon Lee, 2012, Journal of the American Chemical Society.

Identification of a novel small molecule targeting UQCRB of mitochondrial complex III and its anti-angiogenic activity.

H. Kwon, G. Han, H. Jung, 2011, Bioorganic & medicinal chemistry letters.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

P. Sorger, R. Everley, S. Knapp, 2019, Cell chemical biology.

Identification of a Small Benzamide Inhibitor of Influenza Virus Using a Cell-Based Screening

K. No, Ky-Youb Nam, B. Seong, 2016, Chemotherapy.

Discovery of Novel 11β-HSD1 Inhibitors by Pharmacophore-Based Virtual Screening

S. Ahn, N. Kim, Chang-Kyun Han, 2012 .

Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5

In-kyu Lee, J. Moon, K. Park, 2019, Diabetes & metabolism journal.

Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

Joo Young Lee, H. H. Park, Yunjin Jung, 2016, Scientific Reports.

Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.

Z. Park, N. Kim, J. Lee, 2013, Biochemical and biophysical research communications.

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

N. Gray, S. Ficarro, J. Marto, 2019, Bioorganic & medicinal chemistry letters.

A bioorthogonal approach for imaging the binding between Dasatinib and its target proteins inside living cells.

I. Choi, Z. Lee, Jong-Soon Choi, 2016, Chemical communications.

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.

See-Hyoung Park, Jongsung Lee, Nguyen Minh Phuc, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

M. McKeown, Xiang Xu, Dennis L. Buckley, 2018, ACS chemical biology.

1‐Dehydro‐[10]‐gingerdione from ginger inhibits IKKβ activity for NF‐κB activation and suppresses NF‐κB‐regulated expression of inflammatory genes

J. Hong, S. Ryu, B. Hwang, 2012, British journal of pharmacology.

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders.

S. Han, Youngsoo Kim, S. H. Park, 2012, Pharmacology & therapeutics.

Identification of methyl violet 2B as a novel blocker of focal adhesion kinase signaling pathway in cancer cells.

Jiyeon Lee, G. Han, T. Sim, 2013, Biochemical and biophysical research communications.

Structural modeling of V299L and E459K Bcr-Abl mutation, and sequential therapy of tyrosine kinase inhibitors for the compound mutations.

B. Cho, Dong-Wook Kim, Soo-hyun Kim, 2009, Leukemia research.

The Application of REDOR NMR to Understand the Conformation of Epothilone B

Jae-Ho Lee, SangGap Lee, H. Lee, 2017, International journal of molecular sciences.

A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells.

Hyung Gyun Kim, E. Han, H. Jeong, 2017, Oncotarget.

Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase.

S. K. Kim, S. Lee, Thanigaimalai Pillaiyar, 2016, European journal of medicinal chemistry.

In vitro metabolism of an estrogen‐related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s

In-kyu Lee, J. Shon, Kwang-Hyeon Liu, 2015, Biopharmaceutics & drug disposition.

Characterization of a highly selective inhibitor of the Aurora kinases.

S. Knapp, N. Gray, A. Chaikuad, 2017, Bioorganic & medicinal chemistry letters.

Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1

Songhun Yoon, Jaebum Lim, N. Kim, 1997 .

Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor.

I. Shin, T. Sim, N. Kim, 2017, European journal of medicinal chemistry.

Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoisomers

H. Choi, J. Hah, T. Sim, 2012 .

OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo

Y. Bae, E. Park, J. A. Kim, 2017, PloS one.

Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.

D. Song, Minkyun Kim, C. Pan, 2014, International journal of oncology.

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors.

Min-Su Jung, Kyung Ah Koo, N. Kim, 2009, Bioorganic & medicinal chemistry letters.

Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.

Ki Young Lee, Cheol Kyu Han, Jeong Hyeok Yoon, 2006, Journal of medicinal chemistry.

Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety.

Y. Na, W. Cho, Youngjoo Kwon, 2012, European journal of medicinal chemistry.

Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors.

Seo Yun Jung, Yong Sup Lee, S. Chung, 2008, Bioorganic & medicinal chemistry letters.

Theoretical studies of the effects of ortho-methyl substitution on SN1 and SN2 processes at primary and secondary benzylic carbons†

Chang Kon Kim, Ikchoon Lee, N. Kim, 1993 .

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Sridhar Ramaswamy, Taebo Sim, Richard A Young, 2014, Nature.

A Novel Protein–Protein Interaction between RSK3 and IκBα and a New Binding Inhibitor That Suppresses Breast Cancer Tumorigenesis

Jae-Young Kim, S. Chi, Ji Hoon Lee, 2021, Cancers.

Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Robert A. Harris, Chae-Myeong Ha, In-kyu Lee, 2016, Scientific Reports.

Novel Quercetin Derivative of 3,7-Dioleylquercetin Shows Less Toxicity and Highly Potent Tyrosinase Inhibition Activity

Kechun Liu, Hyun-Jae Shin, Moon-Hee Choi, 2021, International journal of molecular sciences.

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

Charles Y. Lin, W. Hahn, A. Look, 2020, Nature Chemical Biology.

Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations

T. Sim, N. Kim, Yeonui Kwak, 2016, Cancer biology & therapy.

Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.

P. Suh, J. Ryu, Hye-Kyung Park, 2015, Journal of the American Chemical Society.

Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner.

Joo Young Lee, B. Lee, N. Kim, 2015, Journal of ethnopharmacology.

MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity.

S. Nam, J. Hong, S. Han, 2011, The Journal of infectious diseases.

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

P. Jänne, N. Gray, Xianming Deng, 2011, ACS medicinal chemistry letters.

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.

N. Gray, W. Hur, H. Choi, 2018, Journal of medicinal chemistry.

An inhibitor of the interaction of survivin with Smac in mitochondria promote apoptosis.

I. Shin, Insu Shin, N. Kim, 2019, Chemistry, an Asian journal.

Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway

Seung-Hoon Lee, S. Han, C. Shin, 2011, The Journal of antimicrobial chemotherapy.

Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.

In-kyu Lee, Hueng-Sik Choi, S. Cho, 2016, European journal of medicinal chemistry.

Identification of Selective ERRγ Inverse Agonists

In-kyu Lee, Hueng-Sik Choi, S. Cho, 2016, Molecules.

Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer.

C. Paweletz, P. Jänne, L. Sholl, 2016, Cancer discovery.

Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.

W. Hur, Hyomin K. Lee, T. Sim, 2017, Biochimica et biophysica acta. General subjects.

15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136.

Do-Hee Kim, Y. Surh, H. Na, 2018, Cancer letters.

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.

Yong Sup Lee, Yong Zhang, P. Gong, 2009, Bioorganic & medicinal chemistry letters.

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.

Taebo Sim, Sang Min Lim, John Hunter, 2014, Angewandte Chemie.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.

R. Xavier, S. Schreiber, A. Shamji, 2016, ACS chemical biology.

A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants.

T. Sim, Hanna Cho, N. Kim, 2016, Journal of medicinal chemistry.

Expression and purification of biologically active recombinant human paraoxonase 1 from a Drosophila S2 stable cell line.

Sungrae Lee, J. Rho, Jiyeon Yu, 2017, Protein expression and purification.

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.

N. Gray, Tinghu Zhang, Xianming Deng, 2016, ACS medicinal chemistry letters.

Identification of novel resorcinol amide derivatives as potent and specific pyruvate dehydrogenase kinase (PDHK) inhibitors.

In-kyu Lee, I. Shin, T. Sim, 2019, Journal of medicinal chemistry.

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.

Min Goo Lee, Hookeun Lee, Jong-Moon Park, 2011, Journal of the American Chemical Society.

Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation.

Kyoung Tai No, Cheol Kyu Han, Jeong Hyeok Yoon, 2009, Bioorganic & medicinal chemistry.

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing*

H. Kwon, J. Shim, Jiyong Lee, 2010, The Journal of Biological Chemistry.

BCPA {N,N′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1

Jee-Young Lee, Tae-Hoon Lee, Byung-Ju Park, 2018, International journal of molecular sciences.

A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia

H. Koo, Y. Yeom, K. Park, 2015, Molecules and cells.

Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

I. Shin, Kee-In Lee, J. Ahn, 2016, Experimental & Molecular Medicine.

An Investigation of Glyceollin I`s Inhibitory Effect on The Mammalian Adenylyl

Seung-Ho Lee, N. Kim, Dong-chan Kim, 2013 .

Pharmacophore-based virtual screening: a review of recent applications

Nam Doo Kim, Kyun-Hwan Kim, Baik-Lin Seong, 2010, Expert opinion on drug discovery.

X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.

H. Choi, Haelee Kim, Eunhwa Ko, 2021, Journal of medicinal chemistry.

Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277.

W. Hur, H. Choi, N. Jeon, 2017, Journal of medicinal chemistry.

Discovery of novel HCV polymerase inhibitors using pharmacophore-based virtual screening.

S. Ahn, Jaewon Yang, N. Kim, 2011, Bioorganic & medicinal chemistry letters.

Putative therapeutic agents for the learning and memory deficits of people with Down syndrome.

Jung Tae Lee, N. Kim, I. Ha, 2006, Bioorganic & medicinal chemistry letters.

Discovery of a novel potent peptide agonist to adiponectin receptor 1

J. Um, N. Kim, Sunghwan Kim, 2018, PloS one.

Regioselectivity Prediction of CYP1A2-Mediated Phase I Metabolism

Doo Nam Kim, S. Y. Kim, K. No, 2008, J. Chem. Inf. Model..

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.

Min Goo Lee, Hookeun Lee, Jong-Moon Park, 2011, Journal of the American Chemical Society.

Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.

D. Song, Minkyun Kim, C. Pan, 2014, International Journal of Oncology.

Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.

P. Suh, J. Ryu, Hye-Kyung Park, 2015, Journal of the American Chemical Society.