S. Pou

发表

Light-dependent spin trapping of hydroxyl radical from human erythrocytes.

L. Bynoe, J. Gottsch, G. Rosen, 1991, Biochemical and biophysical research communications.

Hematogenous photosensitization. A mechanism for the development of age-related macular degeneration.

L. Bynoe, J. Gottsch, G. Rosen, 1990, Investigative ophthalmology & visual science.

Problems associated with spin trapping oxygen-centered free radicals in biological systems.

D. Hassett, B. Britigan, M. Cohen, 1989, Analytical biochemistry.

Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

C. Green, M. Riscoe, Shravan K Mutyam, 2020, Pharmaceutical development and technology.

LIGHT‐DEPENDENT GENERATION OF SUPEROXIDE FROM HUMAN ERYTHROCYTES

L. Bynoe, J. Gottsch, L. Bynoe, 1992, Photochemistry and Photobiology.

The use of fluorophore‐containing spin traps as potential probes to localize free radicals in cells with fluorescence imaging methods

R. Hosmane, G. Rosen, S. Pou, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase.

K. Reynolds, Z. Yuan, P. Callery, 1992, Chemico-biological interactions.

14N-SPIN TRAPPING OF FREE RADICALS IN THE PRESENCE OF 15N-SPIN LABELED NEISSERIA GONORRHOEAE

D. Hassett, H. Halpern, Myron S. Cohen, 1999 .

In vivo detection of free radicals in real time by low-frequency electron paramagnetic resonance spectroscopy.

H. Halpern, G. Rosen, S. Pou, 1998, Methods in molecular biology.

Spin trapping of hydroxyl radicals in biological systems.

B. Britigan, M. Cohen, G. Rosen, 1994, Methods in enzymology.

Nitroxides as potential contrast enhancing agents for MRI application: Influence of structure on the rate of reduction by rat hepatocytes, whole liver homogenate, subcellular fractions, and ascorbate

G. Rosen, S. Pou, J. Keana, 1987, Magnetic Resonance in Medicine.

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

M. Sonders, S. Mclean, S. Pou, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Free radicals and phagocytic cells

Myron S. Cohen, B. Britigan, G. Rosen, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity.

P. Cerutti, G. Bellomo, P. Sestili, 1989, European journal of biochemistry.

PRODUCTION OF HYDROXYL RADICAL DURING THE OXIDATION OF XANTHINE BY XANTHINE OXIDASE IS DEPENDENT ON THE PRESENCE OF ADVENTITIOUS IRON

G. Buettner, B. Britigan, G. Rosen, 1991 .

Effect of anti-inflammatory drugs on myeloperoxidase-dependent hydroxyl radical generation by human neutrophils.

G. Rosen, S. Pou, C. L. Ramos, 1995, Biochemical pharmacology.

Nitroxide-doped liposomes containing entrapped oxidant: an approach to the "reduction problem" of nitroxides as MRI contrast agents.

S. Pou, J. Keana, 1985, Physiological chemistry and physics and medical NMR.

Application of spin traps to biological systems.

B. Britigan, M. Cohen, G. Rosen, 1990, Free radical research communications.

Spin-trapping and human neutrophils. Limits of detection of hydroxyl radical.

B. Britigan, M. Cohen, G. Rosen, 1989, The Journal of biological chemistry.

Effect of trifluoromethyl ketone‐based elastase inhibitors on neutrophil function in vitro

C. Bonuccelli, P. Bernstein, T. Salcedo, 1998, Journal of leukocyte biology.

Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. The confounding problem of adventitious iron bound to xanthine oxidase.

G. Buettner, B. Britigan, G. Rosen, 1990, The Journal of biological chemistry.

Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control

A. Sawa, S. Seshadri, J. Pevsner, 2013, Translational Psychiatry.

L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide.

L. Roman, A. Starkov, J. Weaver, 2005, Biochemical pharmacology.

The Role of Tetrahydrobiopterin in the Regulation of Neuronal Nitric-oxide Synthase-generated Superoxide*

G. Fiskum, S. Porasuphatana, L. Roman, 2002, The Journal of Biological Chemistry.

Spin-trapping of superoxide by 5,5-dimethyl-1-pyrroline N-oxide: application to isolated perfused organs.

G. Rosen, S. Pou, 1990, Analytical biochemistry.

Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

B. Britigan, M. Cohen, G. Rosen, 1992, The Journal of biological chemistry.

Intracellular spin-trapping of oxygen-centered radicals generated by human neutrophils.

B. Britigan, M. Cohen, G. Rosen, 1989, Biochimica et biophysica acta.

Phagocyte-derived free radicals stimulated by ingestion of iron-rich Staphylococcus aureus: a spin-trapping study.

B. Britigan, M. Cohen, G. Rosen, 1991, The Journal of infectious diseases.

PHAGOCYTES: FREE RADICALS, LACTOFERRIN AND THE LACTOFERRIN RECEPTOR

J. Serody, Myron S. Cohen, B. Britigan, 1991 .

Investigations into the spin trapping of nitric oxide and superoxide: models to explore free radical generation by nitric oxide synthase

S. Porasuphatana, G. Rosen, P. Tsai, 2000 .

Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

C. Suárez, M. Riscoe, Aaron Nilsen, 2020, Parasites & vectors.

Application of spin trapping to human phagocytic cells: insight into conditions for formation and limitation of hydroxyl radical.

B. Britigan, M. Cohen, G. Rosen, 1991, Free radical research communications.

Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

Alyssa J Miller, L. Zakharov, M. Riscoe, 2020, Antimicrobial Agents and Chemotherapy.

Effect of NPC 15669, an inhibitor of neutrophil recruitment and neutrophil-mediated inflammation, on neutrophil function in vitro.

M. Cohen, G. Rosen, G. Cao, 1993, Biochemical pharmacology.

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Galen P. Miley, M. Mather, A. Vaidya, 2015, The American journal of tropical medicine and hygiene.

Conformational, Aqueous Solvation, and pKa Contributions to the Binding and Activity of Cocaine, WIN 35 065-2, and the WIN Vinyl Analog

Alexander D. MacKerell, Biao Yang, Jeremy Wright, 1994 .

Influence of conformation on the EPR spectrum of 5,5-dimethyl-1-hydroperoxy-1-pyrrolidinyloxyl: a spin trapped adduct of superoxide.

Alexander D. MacKerell, H. Halpern, B. Robinson, 2004, The Journal of organic chemistry.

An electron spin resonance study of oxyradical generation in superoxide dismutase- and catalase-deficient mutants of Escherichia coli K-12.

H. Schellhorn, H. Hassan, S. Pou, 1989, Archives of biochemistry and biophysics.

Esters of 5-carboxyl-5-methyl-1-pyrroline N-oxide: a family of spin traps for superoxide.

H. Halpern, B. Robinson, R. Nielsen, 2003, The Journal of organic chemistry.

Issues Pertinent to the in vivo in situ Spin Trapping of Free Radicals

H. Halpern, G. Rosen, P. Tsai, 1999 .

Evaluation of various spin traps for the in vivo in situ detection of hydroxyl radical

G. Rosen, P. Tsai, S. Pou, 1999 .

Detection and imaging of oxygen-centered free radicals with low-frequency electron paramagnetic resonance and signal-enhancing deuterium-containing spin traps

H. Halpern, Cheng Yu, G. Rosen, 1993 .

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

David M. Shackleford, Galen P. Miley, M. Mather, 2015, Antimicrobial Agents and Chemotherapy.

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

Galen P. Miley, M. Mather, A. Vaidya, 2014, Journal of medicinal chemistry.

Design of modified pyrroline N-oxide derivatives as spin traps specific for hydroxyl radical

P. Arya, D. Griller, G. Rosen, 1992 .

Synthesis of deuterium- and nitrogen-15-containing pyrroline 1-oxides: a spin-trapping study

G. Rosen, S. Pou, J. Keana, 1990 .

Mechanism of free-radical generation by nitric oxide synthase.

G. Rosen, P. Tsai, S. Pou, 2002, Chemical reviews.

A pseudoreceptor docking study of 4,5-α-epoxymorphinans with a range of dielectric constants

Jih-Hsiang Chen, Rick Gussio, Sovitj Pou, 1992, Journal of computer-aided molecular design.

Generation of superoxide by purified brain nitric oxide synthase.

S. Snyder, D. Bredt, G. Rosen, 1992, The Journal of biological chemistry.

Use of a low-frequency ESR spectrometer: implications for spin-trapping free radicals, in situ.

H. Halpern, G. Rosen, M. Peric, 1991, Free radical research communications.

A kinetic approach to the selection of a sensitive spin trapping system for the detection of hydroxyl radical.

T. Gladwell, M. Cohen, D. Young, 1994, Analytical biochemistry.

Is there stereoselectivity in spin trapping superoxide by 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide?

M. Bowman, G. Rosen, P. Tsai, 2005, The Journal of organic chemistry.

Superoxide dismutase versus ferricytochrome C: determining rate constants for the spin trapping of superoxide by cyclic nitrones.

J. Weaver, G. Rosen, P. Tsai, 2004, The Journal of organic chemistry.

A fluorophore-containing nitroxide as a probe to detect superoxide and hydroxyl radical generated by stimulated neutrophils.

R. Hosmane, G. Rosen, G. Cao, 1993, Analytical biochemistry.

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

John C. Tan, D. Caridha, Q. Zeng, 2019, Journal of medicinal chemistry.

Spin trapping of nitric oxide by ferro-chelates: kinetic and in vivo pharmacokinetic studies.

H. Halpern, S. Porasuphatana, G. Chandramouli, 1999, Biochimica et biophysica acta.

Use of nitroxides as NMR contrast enhancing agents for joints.

G. Wolf, P. Davis, G. Rosen, 1995, Free radical research.

The insertion and extrusion of heterosulfur bridges. XII. Selectivity and side reactions in the bridging process

S. Pou, L. Klemm, R. Lawrence, 1984 .

Synthesis and properties of some nitroxide .alpha.-carboxylate salts

G. Rosen, S. Pou, J. Keana, 1989 .

Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil

D. V. van Schalkwyk, R. Moon, C. Sutherland, 2020, Antimicrobial Agents and Chemotherapy.

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

A. Vaidya, J. Morrisey, Isaac P. Forquer, 2016, Antimicrobial Agents and Chemotherapy.

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

Choukri Ben Mamoun, S. Africa., L. Bockenstedt, 2016, The Journal of experimental medicine.

Babesia duncani as a model organism to study the development, virulence and drug susceptibility of intraerythrocytic parasites in vitro and in vivo

Choukri Ben Mamoun, Pankaj Singh, M. Riscoe, 2021, bioRxiv.

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

S. Gihaz, M. Riscoe, Aaron Nilsen, 2021, bioRxiv.

Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice

Joachim Müller, A. Hemphill, M. Riscoe, 2018, Front. Vet. Sci..

A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.

M. Riscoe, Haihong Jin, David R. Stuart, 2021, Organic process research & development.

Oxygen Reduction by Nitric-oxide Synthases*

D. Stuehr, G. Rosen, S. Pou, 2001, The Journal of Biological Chemistry.

Novel nitroxides for spin-labelling, -trapping, and magnetic resonance imaging applications

Jane H. Park, G. Rosen, B. Sweetman, 1990 .

Can nitric oxide be spin trapped by nitrone and nitroso compounds?

G. Rosen, S. Pou, W. Surichamorn, 1994, Biochimica et biophysica acta.

Does peroxynitrite generate hydroxyl radical?

T. Gladwell, G. Rosen, S. Pou, 1995, Biochimica et biophysica acta.

Mechanism of Superoxide Generation by Neuronal Nitric-oxide Synthase*

G. Rosen, S. Pou, W. Surichamorn, 1999, The Journal of Biological Chemistry.

Potentiation of quinolinate-induced hippocampal lesions by inhibition of NO synthesis

K. A. Haberny, S. Pou, C. Eccles, 1992, Neuroscience Letters.

Erratum: Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. The confounding problem of adventitious iron bound to xanthine oxidase (The Journal of Biological Chemistry, Vol. 265, (1990) 17533-17538)

G. Buettner, B. Britigan, G. Rosen, 1991 .

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.

D. Koop, P. Davidson, M. Riscoe, 2016, ACS infectious diseases.

Generation of thiyl radical by nitric oxide: a spin trapping study

G. Rosen, S. Pou, 1998 .

Involvement of the perferryl complex of nitric oxide synthase in the catalysis of secondary free radical formation.

S. Porasuphatana, G. Rosen, P. Tsai, 2001, Biochimica et biophysica acta.

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.

L. Zakharov, M. Riscoe, Aaron Nilsen, 2018, ACS infectious diseases.

The Single‐Dose Pharmacokinetics of Midazolam and Its Primary Metabolite in Pediatric Patients after Oral and Intravenous Administration

Sovitj Pou, G. Kearns, J. Blumer, 2001, Journal of clinical pharmacology.

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

P. Rosenthal, K. Reynolds, D. Caridha, 2020, Journal of medicinal chemistry.

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.

R. F. Campbell, M. Mather, A. Vaidya, 2017, ACS infectious diseases.

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

Joanne M. Morrisey, M. Mather, A. Vaidya, 2019, PloS one.

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

Joanne M. Morrisey, M. Mather, A. Vaidya, 2018, bioRxiv.

Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii

Choukri Ben Mamoun, M. Riscoe, Aaron Nilsen, 2016, Antimicrobial Agents and Chemotherapy.

N-hydroxylamine is not an intermediate in the conversion of L-arginine to an activator of soluble guanylate cyclase in neuroblastoma N1E-115 cells.

G. Rosen, E. El-Fakahany, S. Pou, 1991, Biochemical Journal.

Sontochin as a Guide to the Development of Drugs against Chloroquine-Resistant Malaria

D. Hinrichs, K. Wegmann, M. Riscoe, 2012, Antimicrobial Agents and Chemotherapy.

A comparative study of neuronal and inducible nitric oxide synthases: generation of nitric oxide, superoxide, and hydrogen peroxide.

S. Porasuphatana, L. Roman, J. Weaver, 2005, Biochimica et biophysica acta.

Biological studies of a nitroso compound that releases nitric oxide upon illumination.

D. E. Anderson, S. Pou, M. Tod, 1994, Molecular pharmacology.

Perferryl complex of nitric oxide synthase: role in secondary free radical formation.

S. Porasuphatana, G. Rosen, P. Tsai, 2002, Biochimica et biophysica acta.

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

S. Kappe, D. Koop, L. Bleyle, 2019, Malaria Journal.

Babesia duncani as a model organism to study the development, virulence and drug susceptibility of intraerythrocytic parasites in vitro and in vivo.

Choukri Ben Mamoun, Pankaj Singh, M. Riscoe, 2022, The Journal of infectious diseases.

Oxygen Reduction by Nitric-oxide Synthases*

D. Stuehr, G. Rosen, S. Pou, 2001, The Journal of Biological Chemistry.