L. Fader

发表

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

J. Duan, M. Garneau, P. Bonneau, 2014, Antimicrobial Agents and Chemotherapy.

Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis.

E. Carreira, L. Fader, 2004, Organic letters.

Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA.

Y. Tsantrizos, L. Fader, M. Boyd, 2001, The Journal of organic chemistry.

Revealing Atropisomer Axial Chirality in Drug Discovery

O. Hucke, S. LaPlante, A. Jakalian, 2011, ChemMedChem.

Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues.

Y. Tsantrizos, L. Fader, 2002, Organic letters.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

O. Hucke, P. Bonneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

J. Duan, M. Garneau, C. Yoakim, 2014, ACS medicinal chemistry letters.

Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers1

Y. Tsantrizos, L. Fader, M. Boyd, 1997 .

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors

R. Stocco, A. Roulston, Jordan T. F. Young, 2021, Molecular Cancer Therapeutics.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

J. Duan, O. Hucke, M. Garneau, 2013, Bioorganic & medicinal chemistry letters.

Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series

Jean-François Mercier, Yves Bousquet, J. Mercier, 2013, ChemMedChem.

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Wesley I. Sundquist, Stephen W. Mason, W. Sundquist, 2012, Journal of Virology.

2,6‐Lutidine

P. Sampson, L. Fader, T. Janini, 2007 .

Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry

A. Gagnon, M. Duplessis, L. Fader, 2010 .

Total synthesis of bafilomycin A1.

E. Carreira, L. Fader, F. Kleinbeck, 2012, Chemistry.

asymmetric transfer hydrogenation

P. Forgione, L. Fader, 2020, Catalysis from A to Z.

Cover Picture: Revealing Atropisomer Axial Chirality in Drug Discovery (ChemMedChem 3/2011)

O. Hucke, S. LaPlante, A. Jakalian, 2011 .

Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry

A. Gagnon, M. Duplessis, L. Fader, 2010 .

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Araz Jakalian, Sébastien Morin, Yves Bousquet, 2014, ACS medicinal chemistry letters.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties

Y. Tsantrizos, E. L. Myers, L. Fader, 2004 .

Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

N. Moss, D. Goldberg, S. Weldon, 2017, Bioorganic & medicinal chemistry letters.

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains.

S. Léger, J. Burch, Miguel St-Onge, 2020, Bioorganic & Medicinal Chemistry Letters.