A. Chan

发表

IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection

M. Collins, C. Bagnéris, T. Barrett, 2017, Journal of Virology.

Modelling the binding mode of macrocycles: Docking and conformational sampling.

N. Foloppe, I. Chen, A. Chan, 2019, Bioorganic & medicinal chemistry.

N10‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

J. Garthwaite, D. Selwood, T. Bellamy, 2019, Chemical biology & drug design.

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

R. Ketteler, J. Kriston-Vizi, C. Luft, 2018, Front. Cell Dev. Biol..

Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit.

C. Marson, D. Hansen, A. Chan, 2020, Bioorganic & medicinal chemistry letters.

Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.

Jonathan D. Wilden, S. Wells, J. Cooper, 2018, Acta crystallographica. Section D, Structural biology.

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

P. Gane, M. Eskandarpour, M. Balda, 2022, Cells.

N‐Terminal Modification of VEGF‐A C Terminus‐Derived Peptides Delineates Structural Features Involved in Neuropilin‐1 Binding and Functional Activity

P. Frankel, John F. Martin, I. Evans, 2014, Chembiochem : a European journal of chemical biology.

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

G. Waksman, P. Gane, A. Lo, 2013, The Journal of antimicrobial chemotherapy.

Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis

J. Garthwaite, K. Lidster, D. Selwood, 2014, Journal of medicinal chemistry.

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis*

Julia M. Hill, M. Duchen, A. Coker, 2015, The Journal of Biological Chemistry.

Design and synthesis of Coenzyme A analogues as Aurora kinase A inhibitors: An exploration of the roles of the pyrophosphate and pantetheine moieties.

I. Gout, A. Tabor, Y. Tsuchiya, 2020, Bioorganic & medicinal chemistry.

Covalent Aurora A regulation by the metabolic integrator coenzyme A

I. Gout, P. Eyers, V. Filonenko, 2018, bioRxiv.

Covalent Aurora A regulation by the metabolic integrator coenzyme A.

I. Gout, P. Eyers, V. Filonenko, 2020, Redox biology.

In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors

J. Cooper, N. London, F. Delft, 2020, Journal of Structural Biology: X.

N10‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

Tomas C. Bellamy, J. Garthwaite, D. Selwood, 2019, Chemical biology & drug design.

A small molecule PI3Kα activator for cardioprotection and neuroregeneration

Ralitsa R. Madsen, Roger L. Williams, P. Hawkins, 2023, Nature.

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

C. Milagre, S. Tsirka, P. Frankel, 2018, Journal of medicinal chemistry.

A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycan

Fengtang Yang, F. Muntoni, D. Stemple, 2019, EMBO reports.

ScaffoldGraph: an open-source library for the generation and analysis of molecular scaffold networks and scaffold trees

Oliver B Scott, A W Edith Chan, A. Chan, 2020, Bioinform..

Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members

R. Ketteler, J. Kriston-Vizi, C. Luft, 2015, Biochemistry.

Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites.

Roman A Laskowski, R. Laskowski, A. Chan, 2010, Journal of medicinal chemistry.

Architecture and hydration of the arginine‐binding site of neuropilin‐1

P. Frankel, S. Djordjević, R. Rana, 2018, The FEBS journal.

Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. Running title: Mitochondrial protection prevents neurodegeneration in MS

Julia M. Hill, M. Duchen, A. Coker, 2015 .