X. Shan

发表

Magnetic Resonance Microscopy and Immunohistochemistry of the CNS of the Mutant SOD Murine Model of ALS Reveals Widespread Neural Deficits

M. S. Petrik, S. Grant, S. Blackband, 2007, NeuroMolecular Medicine.

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity.

D. Vocadlo, A. Kermode, X. Shan, 2015, Journal of the American Chemical Society.

Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS

D. Vocadlo, C. Krieger, X. Shan, 2009, Neuroscience Letters.

Selective fluorogenic β-glucocerebrosidase substrates for convenient analysis of enzyme activity in cell and tissue homogenates.

G. Davies, D. Vocadlo, Liang Wu, 2020, ACS chemical biology.

PHOSPHO-ADDUCIN DISTRIBUTION IN A MURINE TRANSGENIC MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

X. Shan, 2005 .

Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing

D. Vocadlo, T. Gloster, Wesley F. Zandberg, 2018, Angewandte Chemie.

Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis

D. Vocadlo, C. Krieger, X. Shan, 2012, Neuroscience Letters.

Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis

F. Cayabyab, C. Krieger, X. Shan, 2005, Neuroscience.

A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells

R. Jagasia, P. Gilormini, D. Vocadlo, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors.

G. Davies, C. Roth, D. Vocadlo, 2015, Angewandte Chemie.

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

G. Davies, Matthew S Macauley, D. Vocadlo, 2008, Nature chemical biology.

Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates

P. Gilormini, D. Vocadlo, Christina Gros, 2022, Nature Chemical Biology.

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Matthew S Macauley, D. Vocadlo, S. Yuzwa, 2012, Nature chemical biology.

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.

S. Gorski, D. Vocadlo, Roger A Ashmus, 2018, ACS chemical neuroscience.

O-linked N-acetylglucosamine protein modification in mouse models of neurodegenerative diseases

X. Shan, 2011 .

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

C. Gong, D. Vocadlo, N. Watson, 2014, Molecular Neurodegeneration.

The Emerging Link between O-GlcNAc and Alzheimer Disease*

D. Vocadlo, S. Yuzwa, X. Shan, 2014, The Journal of Biological Chemistry.

Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage

D. Gozal, Rugao Liu, S. Qian, 2007, Neurobiology of Disease.

Enhanced De Novo Neurogenesis and Dopaminergic Neurogenesis in the Substantia Nigra of 1‐Methyl‐4‐phyenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinson's Disease‐Like Mice

Chun Luo, Michael Bishop, Rugao Liu, 2006, Stem cells.

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

R. Jagasia, A. Rufer, V. Taylor, 2023, Nature Communications.

Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

Matthew S Macauley, D. Vocadlo, S. Yuzwa, 2010, Chemistry & biology.

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

G. Davies, Matthew S Macauley, D. Vocadlo, 2008, Nature chemical biology.