A. Nivina

发表

Evolution and Diversity of Assembly-Line Polyketide Synthases

C. Khosla, Kai P Yuet, A. Nivina, 2019, Chemical reviews.

Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance

E. Rocha, Jean Cury, D. Bikard, 2017, mBio.

Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality

D. Mazel, M. Schlierf, A. Hartmann, 2017, Nucleic acids research.

Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation

G. Cambray, C. Loot, D. Mazel, 2018, Biotechnology and bioengineering.

The Integron: Adaptation On Demand.

C. Loot, D. Mazel, J. Escudero, 2015, Microbiology spectrum.

GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification

H. Fraser, C. Khosla, Sur Herrera Paredes, 2021, Proceedings of the National Academy of Sciences.

Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation

C. Loot, D. Mazel, V. Parissi, 2016, Nature Communications.

Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites

C. Loot, D. Mazel, J. Escudero, 2016, Nucleic acids research.

Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

O. Tenaillon, C. Loot, D. Mazel, 2020, eLife.

Identification of polyketide biosynthetic gene clusters that harbor self-resistance target genes

C. Khosla, Maureen Hillenmeyer, G. Vandova, 2020, bioRxiv.

Structure-specific DNA recombination sites: Design, validation, and machine learning–based refinement

Jean Cury, Aleksandra Nivina, Didier Mazel, 2020, Science Advances.

Integron Identification in Bacterial Genomes and Cassette Recombination Assays.

C. Loot, D. Mazel, J. Escudero, 2020, Methods in molecular biology.

Engineering of chimeric polyketide synthases using SYNZIP docking domains

Alicia D. D’Souza, C. Khosla, M. Grininger, 2018, bioRxiv.