Beom K. Choi

发表

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-11

Sujung Park, B. Kwon, Hyeon-Woo Lee, 2002, The Journal of Immunology.

Combined treatment with anti-HER2/neu and anti-4-1BB monoclonal antibodies induces a synergistic antitumor effect but requires dose optimization to maintain immune memory for protection from lethal rechallenge

Anbok Lee, Il-Hwan Kim, M. Haque, 2022, Cancer Immunology, Immunotherapy.

Phase I Clinical Trial of 4-1BB-based Adoptive T-Cell Therapy for Epstein-Barr Virus (EBV)-positive Tumors

H. Eom, Je-Jung Lee, B. Kwon, 2016, Journal of immunotherapy.

4-1BB Functions As a Survival Factor in Dendritic Cells1

S. Kang, M. Kim, B. Kwon, 2009, The Journal of Immunology.

Dendritic Cells 4-1 BB Functions As a Survival Factor in Byoung

S. Kang, M. Kim, B. Kwon, 2009 .

4-1BB-based Isolation and Expansion of CD8+ T Cells Specific for Self-Tumor and Non–Self-Tumor Antigens for Adoptive T-cell Therapy

Young-Woo Kim, K. Ryu, Chang H. Kim, 2014, Journal of immunotherapy.

Bfl-1 LBcl-x Lymphocytes by Increasing Expression of T + 4-1 BB Promotes the Survival of CD 8

Sujung Park, B. Kwon, Hyeon-Woo Lee, 2002 .

Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells

B. Kwon, Seonhee Kim, Beom K. Choi, 2021, Nature Communications.

Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E‐cadherin

B. Kwon, Jeffrey E. Green, J. Seong, 2015, Molecular carcinogenesis.

IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model

B. Kwon, Seonhee Kim, Beom K. Choi, 2021, Cells.

Delayed IL-21 treatment preferentially expands peptide-specific CD8+ T cells by reducing bystander activation of T cells.

Eun Gyeong Lee, E. Lee, Sang-Yoon Park, 2019, Immunotherapy.

Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy

R. Mittler, B. Kwon, Beom K. Choi, 2009, Molecular Cancer Therapeutics.

Cisplatin-Induced Nephrotoxicity Synergistic Anticancer Effects and Amelioration of 4-1 BB : − Combination Therapy with Cisplatin and Anti

S. Kang, B. Kwon, Beom K. Choi, 2008 .

Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity.

S. Kang, B. Kwon, Beom K. Choi, 2008, Cancer research.

4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

Y. Bae, B. Kwon, Beom K. Choi, 2015, PloS one.

Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy

B. Kwon, Beom K. Choi, Young H. Kim, 2016, Autophagy.

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity

Hyeon-Woo Lee, Beom K. Choi, 2020, Frontiers in Immunology.

CD137‐inducing factors from T cells and macrophages accelerate the destabilization of atherosclerotic plaques in hyperlipidemic mice

Mi-Ran Lee, J. Seoh, J. Yoo, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

4‐1BB‐dependent inhibition of immunosuppression by activated CD4+CD25+ T cells

J. Bae, S. Sakaguchi, B. Kwon, 2004, Journal of leukocyte biology.

Role of endogenous 4‐1BB in the development of systemic lupus erythematosus

B. Kwon, Beom K. Choi, Jae H. Choi, 2007, Immunology.

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses

H. You, Dong-Hoon Shin, B. Kwon, 2020, Cellular & Molecular Immunology.

Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted

Chang H. Kim, B. Kwon, Beom K. Choi, 2015, The Journal of Immunology.

Increasing IL-15 Enhances Peripheral T Cell Proliferation by In Vivo 4-1BB Deficiency in Myeloid Cells

B. Kwon, Beom K. Choi, S. H. Park, 2015 .

In Vivo 4-1BB Deficiency in Myeloid Cells Enhances Peripheral T Cell Proliferation by Increasing IL-15

B. Kwon, Beom K. Choi, Young H. Kim, 2015, The Journal of Immunology.

Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo.

J. Moffett, Y. Sung, Chang H. Kim, 2011, Cytokine.

Peripheral 4-1BB Signaling Negatively Regulates NK Cell Development through IFN-γ

Chang H. Kim, M. Kim, B. Kwon, 2010, The Journal of Immunology.

Glucocorticoid‐induced tumour necrosis factor receptor family‐related receptor signalling exacerbates hapten‐induced colitis by CD4+ T cells

S. Sakaguchi, B. Kwon, J. Suh, 2006, Immunology.

Immune Responses in 4-1BB (CD137)-Deficient Mice1

Z. Lee, B. Koller, H. Broxmeyer, 2002, The Journal of Immunology.

Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages.

B. Kwon, K. Suk, E. Choi, 2008, Molecular immunology.

CD137-Deficient Mice Have Reduced NK/NKT Cell Numbers and Function, Are Resistant to Lipopolysaccharide-Induced Shock Syndromes, and Have Lower IL-4 Responses1

J. Bae, B. Gebhardt, B. Kwon, 2004, The Journal of Immunology.

4-1BB-mediated immunotherapy of rheumatoid arthritis

Hye-young Park, S. Seo, B. Kwon, 2004, Nature Medicine.

IFN‐γ‐indoleamine‐2,3 dioxygenase acts as a major suppressive factor in 4‐1BB‐mediated immune suppression in vivo

D. Munn, A. Mellor, B. Kwon, 2009, Journal of leukocyte biology.

Reverse signaling through BAFF differentially regulates the expression of inflammatory mediators and cytoskeletal movements in THP‐1 cells

Seung-Hee Lee, B. Kwon, K. Suk, 2010, Immunology and cell biology.

Mice Immune Responses in 4-1BB

Z. Lee, B. Koller, H. Broxmeyer, 2002 .

Immunity in the absence of CD28 and CD137 (4‐1BB) molecules

B. Kwon, Beom K. Choi, G. Wolisi, 2003, Immunology and cell biology.

Polymorphic Region-Specific Antibody for Evaluation of Affinity-Associated Profile of Chimeric Antigen Receptor

H. Eom, H. Ueda, B. Kwon, 2020, Molecular therapy oncolytics.

4‐1BB triggers IL‐13 production from T cells to limit the polarized, Th1‐mediated inflammation

B. Kwon, Hyeon-Woo Lee, Beom K. Choi, 2007, Journal of leukocyte biology.

CRIg signals induce anti‐intracellular bacterial phagosome activity in a chloride intracellular channel 3‐dependent manner

I. Han, Ho Lee, B. Kwon, 2013, European journal of immunology.

Shock Syndromes , and Have Lower IL-4 Resistant to Lipopolysaccharide-Induced NK / NKT Cell Numbers and Function , Are CD 137-Deficient Mice Have Reduced

J. Bae, B. Gebhardt, B. Kwon, 2004 .

Origins and functional basis of regulatory CD11c+CD8+ T cells

Chang H. Kim, B. Kwon, Beom K. Choi, 2009, European journal of immunology.

CD137 (4–1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice

Hyun-Young Park, K. Kwack, Mi-Ran Lee, 2010, Circulation.

4-1BB Signaling Breaks the Tolerance of Maternal CD8+ T Cells That Are Reactive with Alloantigens

S. Kang, B. Kwon, J. Suh, 2012, PloS one.

Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration

Hyo Jin Kim, Sik Yoon, B. Kwon, 2009, Experimental & Molecular Medicine.

The hyaluronic acid‐rich node and duct system is a structure organized for innate immunity and mediates the local inflammation

B. Kwon, Beom K. Choi, Sun-Hee Hwang, 2019, Cytokine.

RELT negatively regulates the early phase of the T‐cell response in mice

Y. Jeon, Ho Lee, B. Kwon, 2018, European journal of immunology.

4-1BB Triggering Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Balance between Th17 and Regulatory T Cells

Chang H. Kim, B. Kwon, Beom K. Choi, 2011, The Journal of Immunology.

Herpesvirus infection of ICAM-1–deficient mice

James M. Hill, B. Gebhardt, Cho-Rok Jung, 2004, Current eye research.

Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis

B. Kwon, K. Suk, E. Choi, 2006, Journal of leukocyte biology.

4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms.

B. Kwon, Beom K. Choi, D. Vinay, 2006, Cytokine.

Alloimmune and Skin Allograft Responses in 4-1BB (CD137)-deficient Mice

A. Srirangam, B. Kwon, J. Suh, 2002 .

MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4+ T cells in herpetic stromal keratitis.

Hye-young Park, B. Kwon, Beom K. Choi, 2008, Molecules and cells.

Blockade of the 4‐1BB (CD137)/4‐1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice

B. Gebhardt, B. Kwon, Beom K. Choi, 2007, Immunology.

Costimulatory pathway blockade in corneal transplantation

B. Gebhardt, B. Kwon, Beom K. Choi, 2007 .

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

A. Azmi, G. Pawelec, E. Ryan, 2015, Seminars in cancer biology.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Gloria S. Huang, Rob J. Kulathinal, C. Smythe, 2015, Seminars in cancer biology.

Pro- and Anti-Tumoral Factors Involved in Total Body Irradiation and Interleukin-2 Conditioning in Adoptive T Cell Therapy of Melanoma-Bearing Rag1 Knock-Out Mice

Dong-Hoon Shin, Eun Mi Go, Seonhee Kim, 2022, Cells.

The repopulating cancer cells in melanoma are characterized by increased mitochondrial membrane potential.

B. Kwon, Beom K. Choi, S. H. Park, 2016, Cancer letters.

Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma: A Preclinical Study

Ki-Taek Nam, H. Gwak, Yura Lee, 2021, Frontiers in Immunology.

Loss of zinc‐finger protein 143 contributes to tumour progression by interleukin‐8‐CXCR axis in colon cancer

H. You, V. Verma, Beom K. Choi, 2019, Journal of cellular and molecular medicine.

TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

H. You, I. Choi, Beom K. Choi, 2021, Molecules and cells.

Plasma complement C7 as a target in non-small cell lung cancer patients to implement 3P medicine strategies

Kyung-Hee Kim, B. Yoo, S. Woo, 2021, EPMA Journal.

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation

B. Kwon, Seonhee Kim, Beom K. Choi, 2016, Cellular &Molecular Immunology.

4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cells.

S. Seo, B. Kwon, Beom K. Choi, 2003, Cellular immunology.

Cancer immunotherapy using tumor antigen-reactive T cells.

B. Kwon, Seonhee Kim, Beom K. Choi, 2018, Immunotherapy.

Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy.

W. Yokoyama, B. Kwon, Beom K. Choi, 2007, Cancer research.

Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

B. Kwon, Seonhee Kim, Beom K. Choi, 2018, Nature Communications.

Absence of 4 1BB gene function exacerbates lacrimal gland inflammation in autoimmune-prone MRL-Faslpr mice.

Tatsuhiko Asai, B. Kwon, Dass S Vinay, 2007, Investigative ophthalmology & visual science.

A Transient Transfection-based Cell Adhesion Assay with 293T Cells.

Beom K. Choi, Rohit Singh, 2021, Bio-protocol.

Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

Beom K. Choi, Rohit Singh, 2019, eLife.

Modulating the Balance between Th17 and Autoimmune Encephalomyelitis by 4-1BB Triggering Ameliorates Experimental

Chang H. Kim, B. Kwon, Sunhye Shin, 2011 .

Regulatory T Cells Modulating the Balance between Th 17 and Autoimmune Encephalomyelitis by 4-1 BB Triggering Ameliorates Experimental

Chang H. Kim, B. Kwon, Beom K. Choi, 2011 .

Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer

Dong-Hoon Shin, S. Kim, Beom K. Choi, 2020, Cancers.

4-1BB Signaling Activates the T Cell Factor 1 Effector/β-Catenin Pathway with Delayed Kinetics via ERK Signaling and Delayed PI3K/AKT Activation to Promote the Proliferation of CD8+ T Cells

Chang H. Kim, B. Kwon, Beom K. Choi, 2013, PloS one.

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies.

Seok Chung, Y. Kim, Hyun Jung Kim, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells

Kyungpyo Park, Chan Kim, Beom K. Choi, 2020, International journal of molecular sciences.

Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8+ T Cell Responses

Beom K. Choi, Chungyong Han, E. Cho, 2023, International Journal of Molecular Sciences.