C. Qin

发表

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

Shaomeng Wang, Chao-yie Yang, J. Stuckey, 2019, Journal of medicinal chemistry.

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.

Shaomeng Wang, Chao-yie Yang, James Delproposto, 2019, Journal of medicinal chemistry.

Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer.

Shaomeng Wang, D. McEachern, B. Miao, 2021, Journal of medicinal chemistry.

Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.

Shaomeng Wang, D. McEachern, B. Miao, 2021, Journal of medicinal chemistry.

Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN

C. Qin, H. Qin, 2019, Oncology letters.

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.

Liu Liu, Shaomeng Wang, J. Stuckey, 2018, Journal of Medicinal Chemistry.

Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review.

Shaomeng Wang, C. Qin, Longchuan Bai, 2019, Drug discovery today. Technologies.

Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells

Wenkai Zhang, C. Qin, Bo Jiang, 2023, Frontiers in Chemistry.

Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.

Shaomeng Wang, J. Stuckey, D. McEachern, 2023, Journal of medicinal chemistry.

Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.

D. McEachern, B. Miao, Mi Wang, 2023, Journal of medicinal chemistry.

miR-152-5p inhibits proliferation and induces apoptosis of liver cancer cells by up-regulating FOXO expression.

C. Qin, D. L. Chang, Z. Yu, 2017, Die Pharmazie.