N. Blaquière

发表

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).

C. Li, R. Rowntree, BinQing Wei, 2019, Bioorganic & medicinal chemistry letters.

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.

Steve Price, E. Bradley, BinQing Wei, 2013, Journal of medicinal chemistry.

Aporphine alkaloid synthesis and diversification via direct arylation

N. Blaquière, K. Fagnou, M. Lafrance, 2007 .

Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors.

M. Belvin, E. Bradley, M. Ultsch, 2013 .

Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids.

N. Blaquière, K. Fagnou, M. Lafrance, 2004, Chemical communications.

Heteroarylation of azine N-oxides.

F. Gosselin, N. Blaquière, S. Staben, 2012, Organic letters.

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).

Adam R. Johnson, Jianwen A. Feng, Brandon J. Bravo, 2017, Journal of medicinal chemistry.

Four-component synthesis of fully substituted 1,2,4-triazoles.

N. Blaquière, S. Staben, 2010, Angewandte Chemie.

Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines.

G. Castanedo, S. Trapp, N. Blaquière, 2011, The Journal of organic chemistry.

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.

E. Bradley, BinQing Wei, J. Lesnick, 2013, Bioorganic & medicinal chemistry letters.

Rapid Synthesis of 1,3,5‐Substituted 1,2,4‐Triazoles from Carboxylic Acids, Amidines, and Hydrazines.

G. Castanedo, S. Trapp, N. Blaquière, 2011 .

Decarboxylative ketone aldol reactions: development and mechanistic evaluation under metal-free conditions.

Sophie A. L. Rousseaux, N. Blaquière, K. Fagnou, 2009, The Journal of organic chemistry.

Ruthenium-catalyzed dehydrogenation of ammonia boranes.

D. Black, S. Gorelsky, N. Blaquière, 2008, Journal of the American Chemical Society.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

Monomeric targeted protein degraders.

Jun Liang, R. Blake, N. Blaquière, 2020, Journal of medicinal chemistry.

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

F. Gamo, E. Fang, Yen-Liang Chen, 2022, Journal of medicinal chemistry.

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Jianwen A. Feng, P. McEwan, Lawren C. Wu, 2018, Journal of medicinal chemistry.

Filling a nick in NIK: extending the half-life of a NIK inhibitor through structure-based drug design.

Matthew L Landry, P. McEwan, Adam Johnson, 2023, Bioorganic & medicinal chemistry letters.

Medicinal chemistry of inhibiting RING-type E3 ubiquitin ligases.

Elisia Villemure, N. Blaquière, S. Staben, 2020, Journal of medicinal chemistry.

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.

Melinda M. Mulvihill, Karen E Gascoigne, R. Rowntree, 2021, Journal of medicinal chemistry.

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform.

Steve Price, M. Belvin, BinQing Wei, 2013, Bioorganic & medicinal chemistry letters.

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

Melinda M. Mulvihill, I. Wertz, W. Fairbrother, 2021, Journal of the American Chemical Society.