Lianshan Zhang

发表

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Q. You, Haopeng Sun, Xiaojin Zhang, 2015, ACS medicinal chemistry letters.

Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

David L Smiley, Patrick Edwards, P. Emmerson, 2005, Bioorganic & medicinal chemistry letters.

Discovery of a β-MSH-derived MC-4R selective agonist

P. Emmerson, H. Hsiung, Saba Husain, 2005 .

Solid-phase synthesis of peptide–heterocycle hybrids containing a tripeptide-derived 6,6-fused bicyclic subunit

W. Kohn, Lianshan Zhang, 2001 .

pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity

J. M. Beals, S. D. Kahl, J. Mayer, 2007, Peptides.

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.

Q. You, Changyong Yang, Xiaojin Zhang, 2020, Journal of medicinal chemistry.

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Lei Wang, Q. You, Lixiao Zhang, 2020, European journal of medicinal chemistry.

Discovery of a beta-MSH-derived MC-4R selective agonist.

P. Emmerson, H. Hsiung, Saba Husain, 2005, Journal of Medicinal Chemistry.

Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

P. Emmerson, H. Hsiung, Saba Husain, 2007, Current topics in medicinal chemistry.

Disulfide as a Constraint to Build Super Potent and Selective Melanocortin-4 Receptor (MC4R) Agonists

P. Emmerson, H. Hsiung, Saba Husain, 2006 .

Orthogonal coupling of unprotected peptide segments through histidyl amino terminus

J. Tam, Lianshan Zhang, 1997 .

Two-peak Elution Profile of a Bispecific VHH-IgG Fusion Protein in Ion Exchange Purification Process caused by Atypical N-Glycosylation

Aihua, N. Li, Xiao-Hong Xu, 2022, Annals of Biotechnology.

Cyclic peptides from unprotected precursors through ring-chain tautomerism

J. Tam, P. Botti, Yi-an Lu, 2002 .

Investigations on Solid‐Phase Peptide Synthesis in N‐to‐C Direction (Inverse Synthesis)

E. Bayer, B. Henkel, Lianshan Zhang, 1997 .

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Organic letters.

Synthesis and Application of Unprotected Cyclic Peptides as Building Blocks for Peptide Dendrimers

James P. Tam, J. Tam, Lianshan Zhang, 1997 .

A new ligation method for N-terminal tryptophan-containing peptides using the Pictet–Spengler reaction

J. Tam, S. Hall, Lianshan Zhang, 2000 .

Lactone and Lactam Library Synthesis by Silver Ion-Assisted Orthogonal Cyclization of Unprotected Peptides†

J. Tam, Lianshan Zhang, 1999 .

Novel concepts for the synthesis of cyclic peptide libraries

J. Tam, Lianshan Zhang, 2002 .

Metal ion-assisted peptide cyclization

J. Tam, Lianshan Zhang, 1997 .

Metal Ion Assisted Peptide Cyclization.

J. Tam, Lianshan Zhang, 1997 .

Targeted estrogen delivery reverses the metabolic syndrome

Bin Yang, Brian Finan, Johannes Beckers, 2012, Nature Medicine.

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.

H. Mo, H. Hsiung, Saba Husain, 2005, Endocrinology.

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Bin Yang, Brian Finan, Tao Ma, 2013, Science Translational Medicine.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

R. Seeley, D. Drucker, P. Pfluger, 2014, Nature Medicine.

Dissecting G Protein-coupled Receptor Signaling Pathways with Membrane-permeable Blocking Peptides

J. Tam, E. sanders-Bush, M. Chang, 2000, The Journal of Biological Chemistry.

Discovery and reduction of tryptophan oxidation-induced IgG1 fragmentation in a polysorbate 80-dependent manner.

Hao Li, Lianshan Zhang, Piaoyang Sun, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human β-MSH(5–22) by dipeptidyl peptidase I and dipeptidyl peptidase IV

H. Hsiung, D. Smiley, M. Heiman, 2005, Peptides.

Combined Solid Phase and Solution Synthesis of the Fully Protected Segment 74-99 of HIV 1-Protease with the Application of a New Trityl-Linker

E. Bayer, B. Henkel, Lianshan Zhang, 1996 .

Retention of the cis proline conformation in tripeptide fragments of bovine pancreatic ribonuclease A containing a non-natural proline analogue, 5,5-dimethylproline

H. Scheraga, E. Welker, D. Rothwarf, 1999 .

Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules.

T. Torgerson, J. Tam, A. Colosia, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

D. Drucker, P. Pfluger, M. Tschöp, 2013, Science Translational Medicine.