J. Díez

发表

Myocardial remodeling after infarction: the role of myofibroblasts

Johan Verjans, W. Matthijs Blankesteijn, Jagat Narula, 2010, Nature Reviews Cardiology.

G. Zalba, M. Fortuño, M. Moreno, 2001 .

HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.

G. Zalba, J. Martínez-González, M. Moreno, 2011, Cardiovascular research.

Loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. A role for neurohumoral agonists?

M. Fortuño, N. Varo, J. Díez, 2007, Cardiovascular research.

Characterization of the protective effects of cardiotrophin-1 against non-ischemic death stimuli in adult cardiomyocytes.

M. Fortuño, J. Díez, N. López, 2005, Cytokine.

Clinical implications of apoptosis in hypertensive heart disease.

Arantxa González, M. Fortuño, B. Lopez, 2003, American journal of physiology. Heart and circulatory physiology.

Genomics and Proteomics in Heart Failure Research

T. Arias, Arantxa González, B. Lopez, 2009 .

Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system.

Arantxa González, B. Lopez, J. Díez, 2004, The Medical clinics of North America.

Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.

Arantxa González, M. Larman, B. Lopez, 2004, Journal of the American College of Cardiology.

PPAR and Local Renin-Angiotensin Systems in Cardiovascular and Metabolic Diseases Associated with Obesity: A Unifying Hypothesis

J. Díez, Gustavo Márquez-Salom, J. Dı́ez, 2013 .

Fibrosis: a living tissue and the infarcted heart.

K. Weber, Yao Sun, J. Díez, 2008, Journal of the American College of Cardiology.

Relationship of the CYBA Gene Polymorphisms with Oxidative Stress and Cardiovascular Risk

G. Zalba, J. Díez, J. Dı́ez, 2010 .

NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases.

G. Zalba, O. Beloqui, A. Fortuño, 2008, Clinical science.

Pathophysiologic and Therapeutic Importance of Tissue ACE: A Consensus Report

E. Lonn, K. Swedberg, H. Schunkert, 2002, Cardiovascular Drugs and Therapy.

Different Effects of Antihypertensive Therapies Based on Losartan or Atenolol on Ultrasound and Biochemical Markers of Myocardial Fibrosis: Results of a Randomized Trial

F. Magrini, A. Zanchetti, B. Dahlöf, 2004, Circulation.

Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure.

Arantxa González, M. Larman, B. Lopez, 2007, Journal of the American College of Cardiology.

Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure.

Arantxa González, M. Larman, B. Lopez, 2006, Journal of the American College of Cardiology.

Peroxisome Proliferator-Activated Receptor α and Hypertensive Heart Disease

J. Díez, J. Beaumont, M. J. Goikoetxea, 2004, Drugs.

Biochemical markers of myocardial remodelling in hypertensive heart disease.

T. Arias, Arantxa González, B. Lopez, 2008, Cardiovascular research.

Angiotensin II and the hypertensive heart: a role for the AT2 receptor?

J. Díez, J. Dı́ez, 2004, Journal of hypertension.

Remodeling in Hypertensive Heart Disease: Role of the Renin-Angiotensin-Aldosterone System

Arantxa González, B. Lopez, J. Díez, 2006 .

The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.

G. Zalba, O. Beloqui, M. Moreno, 2009, Clinical science.

The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism.

G. Frühbeck, J. Gómez-Ambrosi, Amaia Rodríguez, 2007, Endocrinology.

Left Ventricular Hypertrophy and Treatment with Renin Angiotensin System Inhibition

E. Frohlich, J. Díez, J. Dı́ez, 2009 .

Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.

G. Zalba, O. Beloqui, M. Moreno, 2006, Diabetes.

Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome: Role of Reduced IRS2-Dependent Signaling

D. Burks, V. Andrés, G. Zalba, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Role of Reduced IRS2-Dependent Signaling

D. Burks, G. Zalba, O. Beloqui, 2008 .

The influence of obesity on the assessment of carotid intima‐media thickness

J. Castellano, P. Irimia, E. Martı́nez-Vila, 2012, Journal of clinical ultrasound : JCU.

Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases

G. Frühbeck, J. Gómez-Ambrosi, Amaia Rodríguez, 2003, Journal of Physiology and Biochemistry.

Apoptosis in hypertensive heart disease: a clinical approach

Arantxa González, B. Lopez, S. Ravassa, 2006, Current opinion in cardiology.

T1 Measurements Identify Extracellular Volume Expansion in Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers With and Without Left Ventricular Hypertrophy

R. Kwong, E. Orav, M. Jerosch-Herold, 2013, Circulation. Cardiovascular imaging.

Impact of collagen type I turnover on the long-term response to cardiac resynchronization therapy.

J. Gavira, A. Macías, I. García-Bolao, 2008, European heart journal.

Insulin-induced NADPH oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes/macrophages.

G. Zalba, A. Fortuño, J. Díez, 2009, Free radical biology & medicine.

Circulating Biomarkers of Collagen Metabolism in Cardiac Diseases

Arantxa González, B. Lopez, J. Díez, 2010, Circulation.

Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta.

G. Frühbeck, J. Gómez-Ambrosi, Amaia Rodríguez, 2002, Endocrinology.

GLP-1 and cardioprotection: from bench to bedside.

S. Ravassa, J. Díez, Amaia Zudaire, 2012, Cardiovascular research.

Glucagon-like peptide 1 and cardiac cell survival

S. Ravassa, J. Díez, Amaia Zudaire, 2012 .

Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease

Arantxa González, B. Lopez, S. Ravassa, 2009 .

Association of Increased Plasma Cardiotrophin-1 With Inappropriate Left Ventricular Mass in Essential Hypertension

J. Castellano, Arantxa González, J. Barba, 2007, Hypertension.

The stilbene disulfonic acid DIDS stimulates the production of TNF-α in human lymphocytes

E. Larrea, M. Civeira, J. Díez, 1992 .

Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats.

M. Fortuño, J. Díez, N. López, 2006, Journal of molecular and cellular cardiology.

Cardiotrophin-1 in hypertensive heart disease

Arantxa González, B. Lopez, S. Ravassa, 2012, Endocrine.

Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes.

N. López-Andrés, M. Fortuño, J. Díez, 2008, Endocrinology.

Linking cardiac insulin resistance and heart failure: GRK2 as an integrative node

C. Murga, F. Mayor, R. Vila-Bedmar, 2015 .

Atrial fibrillation and biomarkers of myocardial fibrosis in heart failure

T. Kahan, Arantxa González, M. Mejhert, 2014, Scandinavian cardiovascular journal : SCJ.

Profibrotic effects of angiotensin II in the heart: a matter of mediators.

J. Díez, J. Dı́ez, 2004, Hypertension.

Serum soluble ST2 as a biochemical marker of acute heart failure: future areas of research.

J. Díez, 2008, Journal of the American College of Cardiology.

AHA-Circ. Research

G. Zalba, M. Fortuño, A. Fortuño, 2001 .

Chronic AT1 Blockade Stimulates Extracellular Collagen Type I Degradation and Reverses Myocardial Fibrosis in Spontaneously Hypertensive Rats

B. Lopez, N. Varo, J. Díez, 2000 .

Corrigendum to “Preliminary characterisation of the promoter of the human p22phox gene: Identification of a new polymorphism associated with hypertension” [FEBS Lett. 542 (2003) 27–31]

J. Paramo, J. Orbe, G. Zalba, 2010 .

Matrix Metalloproteinase-9 : Implications for Human Atherosclerosis Phagocytic NADPH Oxidase-Dependent Superoxide Production Stimulates

J. Paramo, J. Orbe, G. Zalba, 2007 .

Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C: Potential Clinical Implications in Hypertension

G. Zalba, J. López-Sagaseta, J. Hermida, 2009, Hypertension.

Increased Serum Procollagen type I C-terminal Propeptide Levels are Associated with Left Ventricular Dysfunction in Patients Treated with Anthracycline-based Cancer Chemotherapy

J. Lupón, A. Bayés‐Genís, G. Cediel, 2020 .

Targeting &ggr;-secretases protect against angiotensin II-induced cardiac hypertrophy

V. Andrés, R. Villa-Bellosta, Cristina González-Gómez, 2015, Journal of hypertension.

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

A. Shah, Arantxa González, G. Sawyer, 2019, Journal of the American College of Cardiology.

Nanotechnology Applied to Preserve Extracelular Matrix as Teranostic Tool in Acute Myocardial Infarction.

J. Zamorano, M. Saura, C. Zaragoza, 2019, Revista espanola de cardiologia.

Effects of aldosterone on the heart: beyond systemic hemodynamics?

J. Díez, J. Dı́ez, 2008, Hypertension.

Increased phagocytic NADPH oxidase activity associates with coronary artery calcification in asymptomatic men

M. Landecho, G. Zalba, O. Beloqui, 2017, Free radical research.

Altered degradation of extracellular matrix in myocardial remodelling: the growing role of cathepsins and cystatins.

J. Díez, 2010, Cardiovascular research.

Do microRNAs regulate myocardial fibrosis?

J. Díez, J. Dı́ez, 2009, Nature Clinical Practice Cardiovascular Medicine.

Heart ‘omics’ in AGEing (HOMAGE): design, research objectives and characteristics of the common database

A. Mebazaa, S. Pocock, S. Heymans, 2014, Journal of biomedical research.

Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients

Arantxa González, M. Larman, B. Lopez, 2002, Circulation.

Cardiomyocyte apoptosis in hypertensive cardiomyopathy.

Arantxa González, Arantxa González, María A Fortuño, 2003, Cardiovascular research.

Mechanisms of Increased Susceptibility to Angiotensin II–Induced Apoptosis in Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats

Arantxa González, J. Díez, G. Zalba, 2000, Hypertension.

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects.

Arantxa González, B. Lopez, J. Díez, 2010, American journal of physiology. Heart and circulatory physiology.

Oxidative stress and vascular remodelling

G. Zalba, M. Moreno, A. Fortuño, 2005, Experimental physiology.

Effects and mechanism of organ protection by cardiotrophin-1.

F. J. García-Criado, J. López-Novoa, M. García-Cenador, 2012, Current medicinal chemistry.

The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes.

G. Zalba, O. Beloqui, M. Moreno, 2011, Frontiers in bioscience.

NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension.

G. Zalba, M. Moreno, A. Fortuño, 2005, Antioxidants & redox signaling.

Preliminary characterisation of the promoter of the human p22phox gene: identification of a new polymorphism associated with hypertension

J. Paramo, J. Orbe, G. Zalba, 2003, FEBS letters.

Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?

C. Tschöpe, D. Westermann, Arantxa González, 2013, Cardiovascular research.

Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease?

Arantxa González, B. Lopez, J. Díez, 2002, Journal of molecular and cellular cardiology.

Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction.

Arantxa González, M. Larman, B. Lopez, 2007, European heart journal.

Involvement of cardiomyocyte survival–apoptosis balance in hypertensive cardiac remodeling

Arantxa González, M. Fortuño, J. Díez, 2003, Expert review of cardiovascular therapy.

Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease.

Arantxa González, M. Larman, B. Lopez, 2006, Cardiovascular research.

Urinary proteomics in cardiovascular disease: Achievements, limits and hopes

A. Dominiczak, C. Delles, J. Díez, 2011, Proteomics. Clinical applications.

NADPH Oxidase—Dependent Superoxide Production Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Atherosclerotic Disease

G. Zalba, O. Beloqui, M. Moreno, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Atherosclerosis: Is it time for a new name?

J. Paramo, O. Beloqui, J. Díez, 2001, Circulation.

Mechanisms of Disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease

Arantxa González, Arantxa González, Ramón Querejeta, 2005, Nature Clinical Practice Cardiovascular Medicine.

A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone.

F. Zannad, P. Rossignol, B. Martín-Fernández, 2011, American journal of physiology. Heart and circulatory physiology.

microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1 up-regulation.

B. Schroen, S. Heymans, Arantxa González, 2014, Clinical science.

Compelling Benefit of Soluble Suppression of Tumorigenicity‐2 in Post–Myocardial Infarction Estimation of Risk: The Time Is Right for Its Routine Use in the Clinic

A. Bayés‐Genís, J. Díez, J. Dı́ez, 2017, Journal of the American Heart Association.

Surrogate markers for cardiovascular disease: structural markers.

B. Dahlöf, G. Mancini, J. Díez, 2004, Circulation.

C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis.

P. Libby, J. Paramo, J. Orbe, 2006, Journal of the American College of Cardiology.

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

W. Paulus, W. Linke, C. Ottenheijm, 2013, Circulation: Heart Failure.

Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease.

J. Paramo, J. Orbe, J. Rodríguez, 2008, Revista espanola de cardiologia.

Structural Alterations in Arterial Stiffness: Role of Arterial Fibrosis

J. Díez, J. Dı́ez, 2014 .

A translational approach to myocardial remodelling.

G. Ertl, J. Díez, J. Dı́ez, 2008, Cardiovascular research.

New targets to treat the structural remodeling of the myocardium.

Arantxa González, B. Lopez, S. Ravassa, 2011, Journal of the American College of Cardiology.

Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytes.

R. Carr, S. Ravassa, J. Díez, 2011, American journal of physiology. Heart and circulatory physiology.

Galectin‐3 and histological, molecular and biochemical aspects of myocardial fibrosis in heart failure of hypertensive origin

Arantxa González, M. Larman, B. Lopez, 2015, European journal of heart failure.

Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis.

A. Shah, Arantxa González, G. Zalba, 2013, Clinical science.

Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells.

A. Ortiz, J. Egido, C. Gómez-Guerrero, 2009, Cardiovascular research.

Polymorphisms and Promoter Overactivity of the p22 phox Gene in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

G. Zalba, M. Fortuño, A. Fortuño, 2001, Circulation research.

Clinical aspects of hypertensive myocardial fibrosis

Arantxa González, B. Lopez, J. Díez, 2001, Current opinion in cardiology.

Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide.

Arantxa González, Arantxa González, Begoña López, 2008, Kidney international. Supplement.

Impact of acute hypertension transients on diastolic function in patients with heart failure with preserved ejection fraction

F. Fernández‐Avilés, J. Bermejo, R. Yotti, 2017, Cardiovascular research.

Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.

T. Smani, L. Boscá, V. Cachofeiro, 2012, Cardiovascular research.

Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome.

M. Fortuño, N. Varo, J. Díez, 2008, American journal of physiology. Endocrinology and metabolism.

G Protein–Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity

C. Murga, M. Lorenzo, F. Mayor, 2010, Diabetes.

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.

J. Lasarte, Arantxa González, P. Sarobe, 2008, Cardiovascular research.

Oxidative Stress, Endothelial Dysfunction and Cerebrovascular Disease

G. Zalba, O. Beloqui, M. Moreno, 2007, Cerebrovascular Diseases.

Cardiomyocyte Apoptotic Cell Death in Arterial Hypertension: Mechanisms and Potential Management

J. Díez, G. Zalba, M. Fortuño, 2001, Hypertension.

Ultrasonic Backscatter and Serum Marker of Cardiac Fibrosis in Hypertensives

Nerea Varo, A. Maceira, J. Barba, 2002, Hypertension.

Insulin‐like growth factor binding proteins in arterial hypertension: relationship to left ventricular hypertrophy

M. Gil, J. Díez, I. Monreal, 1995, Journal of hypertension.

Cardiac resynchronization therapy-induced left ventricular reverse remodelling is associated with reduced plasma annexin A5.

T. Arias, J. Gavira, A. Macías, 2010, Cardiovascular research.

Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions

Arantxa González, P. Delerive, N. Diguet, 2021, Journal of cardiovascular pharmacology.

A synthetic peptide from transforming growth factor-β₁ type III receptor inhibits NADPH oxidase and prevents oxidative stress in the kidney of spontaneously hypertensive rats.

Arantxa González, G. Zalba, B. Lopez, 2013, Antioxidants & redox signaling.