D. Sweeny

发表

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen

V. Markovtsov, C. Low, Y. Hitoshi, 2009, Journal of Cancer Research and Clinical Oncology.

Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation.

R. Diasio, S. Barnes, D. Sweeny, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.

R. Diasio, S. Barnes, D. Sweeny, 1988, Cancer research.

Biological properties of the 2-fluoro-beta-alanine conjugates of cholic acid and chenodeoxycholic acid in the isolated perfused rat liver.

R. Diasio, G. Daher, S. Barnes, 1990, Biochimica et biophysica acta.

Effect of aging on the metabolism of p-nitroanisole and p-nitrophenol in isolated rat hepatocytes

D. Sweeny, M. Weiner, 1986, AGE.

Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.

Weiwei Tan, Qingling Zhang, S. Wong, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

Conjugation of p-nitroanisole and p-nitrophenol in hepatocytes isolated from streptozotocin diabetic rats.

P. Eacho, D. Sweeny, M. Weiner, 1981, The Journal of pharmacology and experimental therapeutics.

Effects of glucose and fructose on conjugation of p-nitrophenol in hepatocytes of normal and streptozotocin-diabetic rats.

P. Eacho, D. Sweeny, M. Weiner, 1981, Biochemical pharmacology.

7-ethoxycoumarin O-deethylation in perfused livers from ethanol-fed rats: evidence for an important role of mitochondrial reducing equivalents.

D. Sweeny, L. A. Reinke, J. Tupper, 1987, Pharmacology.

Inhibition of glucuronidation and sulfation by dibutyryl cyclic AMP in isolated rat hepatocytes.

L. Shipley, P. Eacho, D. Sweeny, 1986, Drug metabolism and disposition: the biological fate of chemicals.

Sulfation of acetaminophen in isolated rat hepatocytes. Relationship to sulfate ion concentrations and intracellular levels of 3'-phosphoadenosine-5'-phosphosulfate.

D. Sweeny, L. A. Reinke, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Stereoselective glucuronidation of zileuton isomers by human hepatic microsomes.

D. Sweeny, H. Nellans, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat.

W. Lew, K. Y. Wang, K. Cundy, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.

V. Markovtsov, Y. Hitoshi, D. Payan, 2022, Bioorganic & medicinal chemistry.

Effect of ethanol feeding on hepatic microsomal UDP-glucuronyltransferase activity.

D. Sweeny, L. A. Reinke, 1987, Biochemical pharmacology.

Diminished pentose cycle flux in perfused livers of ethanol-fed rats.

D. Sweeny, L. A. Reinke, P. R. Smith, 1987, Molecular pharmacology.

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies

Paul D. Martin, S. Oliver, C. Brealey, 2016, Drugs in R&D.

Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies

Paul D. Martin, D. Surry, S. Oliver, 2016, Clinical pharmacology in drug development.

Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species

Qingling Zhang, J. Sukbuntherng, J. Haznedar, 2009, Cancer Chemotherapy and Pharmacology.

AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes

B. Viollet, V. Markovtsov, L. Boros, 2013, PloS one.

Bile acid conjugation pattern in the isolated perfused rat liver during infusion of an amino acid formulation.

R. Diasio, S. Barnes, D. Sweeny, 1991, JPEN. Journal of parenteral and enteral nutrition.

2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.

R. Diasio, M. Johnson, S. Barnes, 1990, Biochemical pharmacology.

Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation

Weiqun Li, G. Park, E. Grossbard, 2010, Drug Metabolism and Disposition.

SYNTHESIS OF ACTIVE METABOLITES OF INDOLE PYRROLOTHIAZOLE PAF ANTAGONISTS

S. Davidsen, P. Tapang, D. Albert, 1995 .

Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey

E. Grossbard, D. Sweeny, W. Li, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

D. Mendel, W. Lew, P. Escarpe, 1999, Bioorganic & medicinal chemistry letters.

Glucuronidation of zileuton (A-64077) by human hepatic microsomes.

J. Bouska, D. Sweeny, H. Nellans, 1992, Drug metabolism and disposition: the biological fate of chemicals.

N-chenodeoxycholyl-2-fluoro-beta-alanine: a biliary metabolite of 5-fluorouracil in humans.

R. Diasio, D. Sweeny, M. Martin, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Weiqun Li, G. Park, E. Grossbard, 2010, Drug Metabolism and Disposition.

Metabolism of acetaminophen in hepatocytes isolated from mice and rats of various ages.

D. Sweeny, M. Weiner, 1985, Drug metabolism and disposition: the biological fate of chemicals.