A. Stütz

发表

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

S. A. Nasseri, S. Withers, G. Davies, 2020, Molecules.

Biologically active branched-chain aminocyclopentane tetraols from d-galactose

Ana Torvisco Gomez, S. A. Nasseri, S. Withers, 2019, Monatshefte für Chemie - Chemical Monthly.

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

S. Withers, René Lebl, P. Weber, 2017, Carbohydrate research.

A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

S. Withers, P. Weber, M. Thonhofer, 2017, Bioorganic & medicinal chemistry letters.

N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

S. Withers, R. Fischer, M. Thonhofer, 2017, Carbohydrate research.

5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease.

S. Withers, R. Fischer, R. Saf, 2016, Carbohydrate research.

Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

S. Withers, R. Fischer, P. Weber, 2016, Carbohydrate research.

1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines

S. Withers, R. Furneaux, Richard F. G. Fröhlich, 2011, Carbohydrate research.

Imino sugars and glycosyl hydrolases: historical context, current aspects, emerging trends.

T. Wrodnigg, A. Stütz, 2011, Advances in carbohydrate chemistry and biochemistry.

Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

S. Withers, G. Schitter, T. Wrodnigg, 2010, Chembiochem : a European journal of chemical biology.

Fluorous iminoalditols act as effective pharmacological chaperones against gene products from GLB1 alleles causing GM1-gangliosidosis and Morquio B disease

T. Wrodnigg, Bettina M. Pabst, E. Paschke, 2012, Journal of Inherited Metabolic Disease.

DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts.

G. Schitter, T. Wrodnigg, Andreas J. Steiner, 2010, Molecular genetics and metabolism.

Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones.

T. Wrodnigg, A. Stütz, 2016, Advances in carbohydrate chemistry and biochemistry.

GLYCO 23 XXIII International Symposium on Glycoconjugates

T. Wrodnigg, Dora Markulin, T. Lindhorst, 2015, Glycoconjugate Journal.

D-Xylose (D-Glucose) Isomerase and Related Enzymes in Carbohydrate Synthesis

A. Stütz, H. Häsler, 2001 .

Pharmacological Chaperones for β‐Galactosidase Related to GM1‐Gangliosidosis and Morquio B: Recent Advances

T. Wrodnigg, P. Weber, M. Thonhofer, 2021, Chemical record.

C-5a-substituted validamine type glycosidase inhibitors.

S. Withers, R. Fischer, M. Thonhofer, 2017, Carbohydrate research.

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.

S. Withers, R. Fischer, P. Weber, 2016, Bioorganic & medicinal chemistry letters.

A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.

S. Withers, R. Furneaux, Richard F. G. Fröhlich, 2011, Bioorganic & medicinal chemistry letters.

The Amadori rearrangement as glycoconjugation method: Synthesis of non-natural C-glycosyl type glycoconjugates

T. Wrodnigg, A. Stütz, G. Pototschnig, 2012, Beilstein journal of organic chemistry.

Synthesis of N‐Protected Galactosamine Building Blocks from d‐Tagatose via the Heyns Rearrangement

T. Wrodnigg, A. Stütz, I. Lundt, 2006 .

Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics.

S. Withers, T. Wrodnigg, Andreas J. Steiner, 2006, Bioorganic & medicinal chemistry.

New α-galactosidase-inhibiting aminohydroxycyclopentanes

S. A. Nasseri, S. Withers, T. Wrodnigg, 2021, RSC advances.

Reaction of 1,2-0-Alkylidenehexofuranurono-6,3-Lactones with Diethylaminosulfur Trifluoride (DAST)

H. Sterk, A. Stütz, K. Dax, 1985 .

A Sucrose-Based Approach to Enantiomerically Pure Glycerol Derivatives

A. Stütz, M. Fechter, 1997 .

An Exceptionally Simple Chemical Synthesis of O‐Glycosylated d‐Glucosamine Derivatives by Heyns Rearrangement of the Corresponding O‐Glycosyl Fructoses

T. Wrodnigg, G. Dékány, A. Stütz, 2003 .

Iminosugars as Glycosidase Inhibitors

A. Stütz, 1998 .

Two isosteric fluorinated derivatives of the powerful glucosidase inhibitors, 1-deoxynojirimycin and 2,5-dideoxy-2,5-imino-d-mannitol: Syntheses and glucosidase-inhibitory activities of 1,2,5-trideoxy-2-fluoro-1,5-imino-d-glucitol and of 1,2,5-trideoxy-1-fluoro-2,5-imino-d-mannitol

S. Withers, T. Wrodnigg, G. Legler, 1997 .

Synthesis of 5,6-dimodified open-chain d-fructose derivatives and their properties as substrates of bacterial polyol dehydrogenase

P. Hadwiger, B. Nidetzky, A. Stütz, 2000 .

2,5-dideoxy-2,5-imino-d-mannitol and -d-glucitol. Two-step bio-organic syntheses from 5-azido-5-deoxy-d-glucofuranose and -l-idofuranose; evaluation as glucosidase inhibitors and application in affinity purification and characterisation of invertase from yeast

G. Legler, A. Stütz, A. Berger, 1993 .

Positive attitude, shape, flexibility, added‐value accessories or “just being different”: how to attract a glycosidase

T. Wrodnigg, A. Stütz, 2013 .

Synthesis of four diastereomeric octofuranoses from d-glucofuranurono-6,3-lactone via Grignard reactions

A. Stütz, C. Illaszewicz, K. Dax, 1991 .

Total synthesis of a fully protected palytoxin carboxylic acid

J. B. White, M. Martinelli, W. Christ, 1989 .

Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors.

A. Stütz, I. Lundt, S. Andersen, 2000, Carbohydrate research.

Iminosugars as glycosidase inibitors [i.e. inhibitors] : Nojirimycin and beyond

A. Stütz, 1999 .

Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.

S. Withers, T. Wrodnigg, A. Stütz, 2001, Bioorganic & medicinal chemistry letters.

N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase

S. A. Nasseri, S. Withers, T. Wrodnigg, 2020, Molecules.

Chemical and chemo-enzymatic approaches to glycosidase inhibitors with basic nitrogen in the sugar ring

A. Stütz, M. Ebner, A. D. Raadt, 1997 .

Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.

S. Withers, T. Wrodnigg, Andreas J. Steiner, 2004, Bioorganic & medicinal chemistry.

A novel synthetic application of glucose isomerase: Quantitative conversion of D-glucose and L-idofuranose, derivatives modified at position five into the corresponding D-fructo- and L-sorbopyranoses.

M. Grasser, A. Stütz, A. Berger, 1992 .

Tetrafluoroboric acid, an efficient catalyst in carbohydrate protection and deprotection reactions

A. Stütz, K. Dax, R. Albert, 1985 .

Sugar with endocyclic heteroatoms other than oxygen

T. Wrodnigg, P. Greimel, A. Stütz, 2005 .

A novel approach to the 1-deoxynojirimycin system: synthesis from sucrose of 2-acetamido-1, 2-dideoxynojirimycin, as well as some 2-N-modified derivatives.

G. Legler, A. Stütz, G. Gradnig, 1996, Carbohydrate research.

A simple convergent synthesis of the mannosidase inhibitor 1-deoxymannonojirimycin for sucrose

A. Stütz, A. D. Raadt, 1992 .

Synthesis of 1,5-dideoxy-1,5-imino-d-arabinitol (5-nor-l-fuco-1-deoxynojirimycin) and its application for the affinity purification and characterisation of α-l-fucosidase

G. Legler, A. Stütz, H. Immich, 1995 .

Synthesis of a novel α-glucoside of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-d-mannitol via enzymatic glucosylation of 5-azido-5-deoxy-d-fructopyranose

A. Stütz, K. Dax, M. Ebner, 1997 .

Carbohydrate triflates: reaction with nitrite, leading directly to epi-hydroxy compounds

A. Stütz, K. Dax, R. Link, 1983 .

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

S. Withers, A. Vasella, N. Strynadka, 2007, Angewandte Chemie.

Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.

S. Withers, A. Hermetter, T. Wrodnigg, 2001, Bioorganic & medicinal chemistry letters.

Synthesis of regio- and stereospecifically C-deuterated derivatives of glycosidase inhibitors 1-deoxymannonojirimycin and 2,5-dideoxy-2,5-imino-d-mannitol by intramolecular reductive amination employing deuterium gas

A. Stütz, A. Berger, C. Mirtl, 1998 .

Acetyl Migration in Partially Acetylated D-Glucopyrano-Sides and Acylamidohexopyranosides

A. Stütz, K. Dax, H. Weidmann, 1983 .

Simple syntheses of 4-O-glucosylated 1-deoxynojirimycins from maltose and cellobiose.

Andreas J. Steiner, A. Stütz, 2004, Carbohydrate research.

L-Idoseptanosides : substrates of D-glucosidases?

S. Withers, T. Wrodnigg, Andreas J. Steiner, 2006 .

Synthesis of Some New 6,7-Unsaturated Octuronates From 5-O-tert-Butyldimethylsilyl-1,2-O-Isopropylidene-α-D-gluco-and β-L-ido-Hexodialdose and their Transformation into Octoses and Octitols via Osmylation

A. Stütz, K. Dax, A. Berger, 1992 .

A one-step C-linked disaccharide synthesis from carbohydrate allylsilanes and tri-O-acetyl-D-glucal.

A. Stütz, A. de Raadt, 1991, Carbohydrate research.

Sugar Analogues with Basic Nitrogen in The Ring as Anti-Infectives

T. Wrodnigg, W. Severn, A. Stütz, 2000 .

Fine tuning of beta-glucosidase inhibitory activity in the 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) system.

S. Withers, T. Wrodnigg, A. Stütz, 2006, Carbohydrate research.

Glucose isomerase catalysed isomerisation reactions of (2R,3R)-configured aldofuranoses into the corresponding open-chain 2-ketoses

A. Stütz, M. Ebner, 1997 .

Golgi endomannosidase inhibitor, alpha-D-glucopyranosyl-(1 --> 3)-1-deoxymannojirimycin: a five-step synthesis from maltulose and examples of N-modified derivatives.

A. Stütz, J. Spreitz, 2004, Carbohydrate research.

A simple access to the D-mannosidase inhibitor, 1-deoxymannojirimycin.

T. Wrodnigg, A. Stütz, J. Spreitz, 2002, Carbohydrate research.

1,5-anhydro-D-fructose from D-fructose.

G. Dékány, A. Stütz, Fabian Niedermair, 2007, Carbohydrate research.

Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose.

Andreas J. Steiner, G. Dékány, A. Stütz, 2006, Carbohydrate research.

Non-natural aldofuranosides as substrates of a β-glucosidase

S. Withers, T. Wrodnigg, P. Greimel, 2005 .

Epimerisation, isomerisation and rearrangement reactions of carbohydrates

A. Stütz, 2001 .

Glucose isomerase (EC 5.3.1.5) as a reagent in carbohydrate synthesis: success and failures with the isomerisation of non-natural derivatives of d-

A. Stütz, M. Ebner, A. D. Raadt, 1994 .

D-XYLOSE (D-GLUCOSE) ISOMERASE (EC 5.3.1.5): OBSERVATIONS AND COMMENTS CONCERNING STRUCTURAL REQUIREMENTS OF SUBSTRATES AS WELL AS MECHANISTIC FEATURES

H. Weber, A. Stütz, H. Häusler, 2001 .

Nickel(II)-Catalysed Transformations of 5-Azido-5-deoxy-d-glucofuranose and of 5-Azido-5-deoxy-l-idofuranose

P. Hadwiger, A. Stütz, A. Lechner, 1998 .

The Heyns Rearrangement Revisited: An Exceptionally Simple Two-Step Chemical Synthesis of D-Lactosamine from Lactulose.

T. Wrodnigg, A. Stütz, 1999, Angewandte Chemie.

Binding energy and specificity in the catalytic mechanism of yeast aldose reductases

P. Hadwiger, B. Nidetzky, A. Stütz, 1999 .

Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal β-glucocerebrosidase

S. A. Nasseri, S. Withers, T. Wrodnigg, 2019, Monatshefte für Chemie - Chemical Monthly.

Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors

S. Withers, G. Schitter, T. Wrodnigg, 2010, Beilstein journal of organic chemistry.

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

T. Wrodnigg, C. Ortiz Mellet, J. G. García Fernández, 2010, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 1,5-Dideoxy-1,5-iminoxylitol–Amino Acid Hybrids as Xylosidase Inhibitors

S. Withers, T. Wrodnigg, Andreas J. Steiner, 2009 .

N-Alkylated Derivatives of 1,5-Dideoxy-1,5-iminoxylitol as β -Xylosidase and β -Glucosidase Inhibitors

S. Withers, K. Rupitz, A. Stütz, 2002 .

N-Alkylated Derivatives of 1,5-Dideoxy-1,5-iminoxylitol as β-Xylosidaseand β-Glucosidase Inhibitors

S. Withers, K. Rupitz, A. Stütz, 2002 .

Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.

E. Bause, G. Legler, A. Stütz, 1992 .

Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols--a proof-of-concept study.

S. Withers, A. Hermetter, T. Wrodnigg, 2008, Bioorganic & medicinal chemistry letters.

Carbohydrate triflates: Introduction of substituents by double inversion at C-4" of kanamycin A

A. Stütz, K. Dax, R. Albert, 1984 .

Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors.

S. Withers, T. Wrodnigg, Andreas J. Steiner, 2007, Carbohydrate research.

Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols.

S. Withers, T. Wrodnigg, P. Greimel, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel biotin-iminoalditol conjugates.

S. Withers, G. Schitter, T. Wrodnigg, 2010, Bioorganic & medicinal chemistry letters.

1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines.

S. Withers, R. Furneaux, Richard F. G. Fröhlich, 2010, Carbohydrate research.

2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors.

S. Withers, G. Schitter, T. Wrodnigg, 2009, Tetrahedron, asymmetry.

1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.

S. Withers, G. Schitter, T. Wrodnigg, 2008, Bioorganic & medicinal chemistry.

Timely research perspectives in carbohydrate chemistry

W. Schmid, A. Stütz, 2002 .

The Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation

T. Wrodnigg, A. Stütz, 2012 .

Chemical modification of amikacin at C-4'' with inversion of configuration.

J. Hildebrandt, A. Stütz, K. Dax, 1985, The Journal of antibiotics.

Chemical Modification of Kanamycin A. II. Nucleophilic Displacement Reactions of Kanamycin-A-4″-sulfonates

A. Stütz, K. Dax, H. Weidmann, 1982 .

Synthesis of (1-13C)-1-deoxynojirimycin

A. Stütz, A. Berger, M. Ebner, 1995 .

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

S. A. Nasseri, S. Withers, T. Wrodnigg, 2018, Molecules.

Binding and catalysis by yeast aldose reductase: a substrate-analog approach with new aldose derivatives.

P. Hadwiger, B. Nidetzky, A. Stütz, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of fluorinated kanamycin A derivatives

A. Stütz, K. Dax, R. Albert, 1983 .

Olefin Metathesis in Carbohydrate Chemistry

P. Hadwiger, T. Wrodnigg, R. Madsen, 2000 .

Ni(Ii)-Catalysed Reactions of Free D-Fructose Derivatives Modified at Positions C-5 and/or C-6

P. Hadwiger, A. Stütz, 1998 .

Synthesis of 1-amino-1,2,5-trideoxy-2,5-imino-d-mannitol, a novel analogue of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-d-mannitol, via an Amadori rearrangement of 5-azido-5-deoxy-d-glucofuranose

S. Withers, T. Wrodnigg, A. Stütz, 1997 .

Biologically Active 1-Aminodeoxy and 1-O-Alkyl Derivatives of The Powerful D-Glucosidase Inhibitor 2,5-Dideoxy-2,5-Imino-D-Mannitol

S. Withers, T. Wrodnigg, P. Greimel, 2000 .

Synthese Fluorierter Kanamycin-A-derivate, Modifizierung der Positionen “4 and 6”

A. Stütz, K. Dax, R. Albert, 1984 .

Chemical modifications of kanamycin A Synthesis of 4″-deoxy and 4″-epi-halogenodeoxy kanamycin A☆

A. Stütz, K. Dax, H. Weidmann, 1982 .

The crystal and molecular structures of 1,2,3,4,5,6,7,8-octa-O-acetyl-L-threo-L-altro- and -L-threo-L-galacto-octitol

M. Morf, A. Stütz, B. Zimmer, 1993 .

From secondary alcohols to tertiary fluoro substituents: A simple route to hydroxymethyl branched sugars with a fluorine substituent at the branching point.

H. Weber, R. Fischer, R. Saf, 2016, Carbohydrate research.

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Spencer J. Williams, J. Thomas-Oates, A. Thompson, 2012, Proceedings of the National Academy of Sciences.

Synthetic applications of glucose isomerase: isomerisation of C-5-modified (2R,3R,4R)-configured hexoses into the corresponding 2-ketoses

A. Stütz, M. Fechter, 1999 .

Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase.

V. Křen, T. Wrodnigg, R. Fischer, 2023, Bioorganic chemistry.

ENZYMATIC O-GALACTOSYLATION OF SELECTED FREE AS WELL AS PARTIALLY PROTECTED KETOHEXOSES

T. Wrodnigg, A. Stütz, B. Eder, 2001 .

Iminosugars and relatives as antiviral and potential anti-infective agents.

T. Wrodnigg, P. Greimel, A. Stütz, 2003, Current topics in medicinal chemistry.

Two routes to enantiomerically pure 3-aminoinosose derivatives

R. Ferrier, A. Stütz, 1990 .

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

S. Withers, René Lebl, P. Weber, 2017, Carbohydrate research.

Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase.

T. Wrodnigg, P. Bojarová, M. Thonhofer, 2024, Bioorganic chemistry.