A. Delgado

发表

Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity.

P. Compain, D. Grinberg, L. Vilageliu, 2017, Organic & biomolecular chemistry.

Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α‐1‐C‐Substituted Imino‐D‐xylitols (DIXs) by Click Chemistry

P. Compain, D. Grinberg, L. Vilageliu, 2014, ChemMedChem.

Chemical Tools to Investigate Sphingolipid Metabolism and Functions

A. Llebaria, J. Casas, G. Fabriàs, 2007, ChemMedChem.

Investigation of original multivalent iminosugars as pharmacological chaperones for the treatment of Gaucher disease.

D. Hazelard, P. Compain, J. Aerts, 2016, Carbohydrate research.

Aminocyclitols as Pharmacological Chaperones for Glucocerebrosidase, a Defective Enzyme in Gaucher Disease

A. Llebaria, D. Canals, J. Casas, 2007, ChemMedChem.

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

C. Bedia, A. Llebaria, D. Canals, 2008, Chemistry and physics of lipids.

Synthesis and characterization of bichromophoric 1-deoxyceramides as FRET probes.

J. Casas, G. Fabriàs, J. Abad, 2021, Organic & biomolecular chemistry.

Inhibitors of sphingolipid metabolism enzymes.

A. Llebaria, J. Casas, G. Fabriàs, 2006, Biochimica et biophysica acta.

Chemical Probes of Sphingolipid Metabolizing Enzymes

J. Casas, G. Fabriàs, J. Abad, 2015 .

Click chemistry in sphingolipid research.

A. Delgado, Eduardo Izquierdo, 2018, Chemistry and physics of lipids.

Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues.

O. Rabal, J. Teixidó, C. Bedia, 2006, Chemistry and physics of lipids.

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.

A. Llebaria, D. Canals, J. Casas, 2009, Bioorganic & medicinal chemistry.

Approaches to polyunsaturated sphingolipids: new conformationally restrained analogs with minimal structural modifications

F. Goñi, J. Abad, Ingrid Nieves, 2016 .

Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells.

O. Rabal, J. Teixidó, S. Grijalvo, 2007, Bioorganic & medicinal chemistry.

A mechanism-based sphingosine-1-phosphate lyase inhibitor.

J. Casas, G. Fabriàs, J. Abad, 2019, The Journal of organic chemistry.

Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues.

A. Llebaria, J. Casas, A. Delgado, 2007, Organic & biomolecular chemistry.

Aryl trifluoromethyl ketone hydrates as precursors of carboxylic acids and esters1

J. Clardy, A. Delgado, 1992 .

Fluorescent polyene ceramide analogues as membrane probes.

F. Goñi, A. Alonso, J. Sot, 2015, Langmuir : the ACS journal of surfaces and colloids.

Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates.

J. Casas, J. Abad, J. Bujons, 2016, European journal of medicinal chemistry.

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase).

J. Casas, J. Abad, A. Delgado, 2016, Chemistry and physics of lipids.

Straightforward Access to Simplified Sphingosine‐1‐phosphate Analogues

S. Grijalvo, A. Llebaria, A. Delgado, 2007 .

Galacto-configured aminocyclitol phytoceramides are potent in vivo invariant natural killer T cell stimulators.

C. Barra, A. Llebaria, A. Delgado, 2011, Journal of the American Chemical Society.

Aminocyclitol‐Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

C. Bedia, C. Barra, A. Llebaria, 2009, ChemMedChem.

In situ synthesis of fluorescent membrane lipids (ceramides) using click chemistry

F. Goñi, A. Alonso, J. Abad, 2012, Journal of chemical biology.

New aminocyclitols as modulators of glucosylceramide metabolism.

A. Llebaria, J. Casas, A. Delgado, 2005, Organic & biomolecular chemistry.

Studies on the competitive nickel-promoted carbonylative intramolecular cyclization of vinyl and aryl halides with hydroxyalkenes

A. Llebaria, A. Delgado, F. Camps, 1993 .

Stereoselective synthesis of tetrahydrofurans and tetrahydropyrans by Ni(0) promoted tandem cyclization-carbonylation

A. Llebaria, A. Delgado, F. Camps, 1994 .

Asymmetric approaches to cyclopentenones in the Ni(0)-promoted cyclocarbonylation reaction of allyl halides and acetylenes

E. Molins, A. Llebaria, A. Delgado, 1996 .

Regio- and stereoselective synthesis of aminoinositols and 1,2-diaminoinositols from conduritol B epoxide.

A. Llebaria, A. Delgado, P. Serrano, 2005, The Journal of organic chemistry.

Diastereocontrolled synthesis of pyrrolidines by nickel promoted tandem cyclization-quenching of aminobromodienes

A. Llebaria, A. Delgado, J. Moretó, 1998 .

A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12

J. Abad, A. Delgado, Iván Armero, 2015 .

Intramolecular Nitrogen Assistance in the Nickel-Promoted Tandem Cyclization-Capture of Amino-Tethered Vinyl Bromides and Alkenes

A. Llebaria, A. Delgado, D. Solé, 1994 .

Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism.

G. Fabriàs, J. Abad, A. Delgado, 2017, Chemistry and physics of lipids.

Short and enantioselective syntheses of (R)- and (S)-2-hydroxymethyl-1,4-benzodioxan

A. Delgado, G. Leclerc, Mariane Lobato, 1988 .

A practical synthesis of carbamates using an ‘in-situ’ generated polymer-supported chloroformate

A. Llebaria, A. Delgado, D. Mormeneo, 2004 .

Nitrogen Assistance in Intramolecular Nickel-Promoted Tandem Cyclization−Quenching Processes

A. Llebaria, A. Delgado, D. Solé, 1996 .

Studies on the diastereoselective allylation of aldehydes with enantiopure 2-sulfinylallyl building blocks

A. Llebaria, A. Delgado, F. Márquez, 2001 .

An approach to homochiral fused and spiro cyclopentenones

A. Llebaria, A. Delgado, J. Moretó, 1995 .

Barbier-type diastereoselective allylation of alpha-amino aldehydes with an enantiopure 2-sulfinylallyl building block.

E. Molins, A. Llebaria, A. Delgado, 2002, The Journal of organic chemistry.

Synthesis and adrenergic properties of cyclic analogues of methoxamine: 2-amino-1-arylcyclohexanols and 2-amino-1,2,3,4-tetrahydro-1-naphthalenols

G. Rosell, D. Mauleón, A. Delgado, 1988 .

New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.

A. Llebaria, J. Casas, J. Bujons, 2011, Journal of medicinal chemistry.

Medicinal chemistry of aminocyclitols.

A. Delgado, L. Díaz, 2010, Current medicinal chemistry.

Practical synthesis of (-)-1-amino-1-deoxy-myo-inositol from achiral precursors.

Patricia González‐Bulnes, A. Llebaria, J. Casas, 2007, Carbohydrate research.

An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides.

A. Llebaria, A. Delgado, P. Serrano, 2002, The Journal of organic chemistry.

A solid-phase version of the palladium-catalyzed carbonyl allylation by allylic alcohols with SnCl2

A. Llebaria, A. Delgado, Lydia Carde, 2001 .

Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells.

J. Casas, G. Fabriàs, J. Abad, 2013, The Journal of organic chemistry.

A solid-phase version of the Nozaki–Hiyama allylation of aldehydes with supported allylic bromides

A. Llebaria, A. Delgado, K. Breitenstein, 2004 .

New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.

J. Schwartz, A. Delgado, N. Decker, 1989, Journal of medicinal chemistry.

Stereoselective aldol additions catalyzed by dihydroxyacetone phosphate-dependent aldolases in emulsion systems: preparation and structural characterization of linear and cyclic iminopolyols from aminoaldehydes.

C. Solans, J. Joglar, P. Clapés, 2003, Chemistry.

Synthesis and configurational assignment of (R) and (S)-2-bromohexadecanoic acids

Á. Guerrero, A. Delgado, F. Camps, 1995 .

Synthesis of biosynthetic inhibitors of the sex pheromone of Spodoptera littoralis. Part II: Acetylenic and cyclopropane fatty acids.

G. Rosell, Á. Guerrero, A. Delgado, 1992, Chemistry and physics of lipids.

2-aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLC(Bc).

Patricia González‐Bulnes, A. Llebaria, D. Canals, 2010, Bioorganic & medicinal chemistry.

New fluorogenic probes for neutral and alkaline ceramidases[S]

J. Casas, G. Fabriàs, C. Mao, 2019, Journal of Lipid Research.

Formal Protection of Vinylepoxides via Stereospecific Chlorohydrin Formation

A. Llebaria, A. Delgado, Noemí Daviu, 1999 .

Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.

A. Llebaria, J. Casas, J. Bujons, 2010, Journal of medicinal chemistry.

Activity-Based Imaging of Acid Ceramidase in Living Cells.

Yadira F. Ordóñez, E. Schuchman, T. Levade, 2019, Journal of the American Chemical Society.

Selective chaperone effect of aminocyclitol derivatives on G202R and other mutant glucocerebrosidases causing Gaucher disease.

D. Grinberg, L. Vilageliu, J. Aerts, 2014, The international journal of biochemistry & cell biology.

Computational Prediction of Structure-Activity Relationships for the Binding of Aminocyclitols to β-Glucocerebrosidase

Johan Åqvist, Antonio Delgado, Hugo Gutiérrez-de-Terán, 2011, J. Chem. Inf. Model..

Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells.

J. Casas, G. Fabriàs, J. Abad, 2021, European journal of medicinal chemistry.

Click and count: specific detection of acid ceramidase activity in live cells†

Young‐Tae Chang, Xiao Liu, J. Casas, 2020, Chemical science.

Azide‐Tagged Sphingolipids: New Tools for Metabolic Flux Analysis

J. Casas, G. Fabriàs, J. Abad, 2015, Chembiochem : a European journal of chemical biology.

Ceramidases in hematological malignancies: senseless or neglected target?

C. Bedia, J. Casas, G. Fabriàs, 2011, Anti-Cancer Agents in Medicinal Chemistry.

Aldol additions of dihydroxyacetone phosphate to N-Cbz-amino aldehydes catalyzed by L-fuculose-1-phosphate aldolase in emulsion systems: inversion of stereoselectivity as a function of the acceptor aldehyde.

J. Joglar, J. Calveras, P. Clapés, 2005, Chemistry.

Diastereoselective Route to Piperidine and Indolizidine Scaffolds From Enantiopure Vinylsulfinyl-Containing Amino Alcohols

A. Llebaria, A. Delgado, R. Montoro, 2003 .

C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

M. Cabot, J. Casas, G. Fabriàs, 2012, Breast Cancer Research and Treatment.

Inhibition of acid ceramidase by a 2‐substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N‐(4‐hydroxyphenyl) retinamide

M. Cabot, Ramin Karimi, J. Casas, 2011, The Prostate.

Natural products as platforms for the design of sphingolipid-related anticancer agents.

J. Casas, G. Fabriàs, J. Abad, 2013, Advances in cancer research.

3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells.

Yadira F. Ordóñez, C. Bedia, Jéssica González, 2016, Molecular bioSystems.

From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor.

Yadira F. Ordóñez, J. Casas, G. Fabriàs, 2017, Chemical communications.

Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.

S. Pyne, N. Pyne, J. Long, 2009, Stem cells and development.

A Straightforward Protocol for the Solution‐Phase Parallel Synthesis of Ceramide Analogues

S. Grijalvo, A. Llebaria, A. Delgado, 2008 .

On the regio- and stereoselective synthesis of aminocyclitols from cyclitol epoxides: the effect of Li as a chelating agent.

J. de Pablo, J. Anglada, A. Llebaria, 2005, Chemistry.

A Straightforward Protocol for the Solution‐Phase Parallel Synthesis of Ceramide Analogues.

S. Grijalvo, A. Llebaria, A. Delgado, 2008 .

3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate.

F. Simbari, J. Casas, G. Fabriàs, 2012, Bioorganic & medicinal chemistry.

Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors.

J. Casas, J. Abad, J. Bujons, 2016, Bioorganic & medicinal chemistry.

A Practical Access to 1,2-Diaminophytosphingolipids.

A. Llebaria, A. Delgado, Y. Harrak, 2009 .

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones.

R. Eritja, F. Albericio, A. Aviñó, 2008, Bioorganic & medicinal chemistry letters.

Iodocyclization of O-(3-Cyclohexenyl)thiocarbamidates. An Unexpected Approach to Vicinal cis-Aminocyclohexenols.

E. Molins, A. Llebaria, A. Delgado, 2000 .

Combinatorial approach to N-substituted aminocyclitol libraries by solution-phase parallel synthesis and preliminary evaluation as glucocerebrosidase inhibitors.

A. Llebaria, J. Casas, A. Delgado, 2007, Journal of combinatorial chemistry.

The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents

B. Crosas, A. Delgado, Bernat Coll-Martínez, 2020, Molecules.

Synthesis of potential inhibitors of the biosynthesis of the sex pheromone of Spodoptera littoralis. Part I: Monofluorinated fatty acids☆

Á. Guerrero, M. Ruiz, A. Delgado, 1991 .

A catalytic version of a nickel promoted intramolecular tandem cyclization-cyanation process

A. Llebaria, A. Delgado, Susana Hinojosa, 1999 .

Total synthesis of (-)-ovatolide

J. Clardy, A. Delgado, 1993 .

The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells.

J. Casas, G. Fabriàs, J. Abad, 2017, Chemical communications.

Structure and synthesis of a new butanolide from a marine actinomycete

J. Clardy, L. Brinen, P. Jensen, 1991 .

Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors.

A. Delgado, M. Martínez-Cartró, 2016, Current medicinal chemistry.

A Practical Access to 1,2‐Diaminophytosphingolipids

A. Llebaria, A. Delgado, Y. Harrak, 2008 .

Asymmetric Synthesis of Aryl 2-Piperidyl Methanols from a Chiral α-Aminonitrile Precursor

A. Delgado, David Mauleœn, 1988 .

Asymmetric Synthesis of Aryl-2-piperidylmethanols from a Chiral α-Aminonitrile Precursor.

D. Mauleón, A. Delgado, 1988 .

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

Sam Benson, Antonio Fernandez, Nicole D Barth, 2019, Angewandte Chemie.

Sphingolipid modulation: a strategy for cancer therapy.

C. Bedia, J. Casas, G. Fabriàs, 2012, Anti-cancer agents in medicinal chemistry.

A New and Diastereoselective Synthesis of Threo-Aryl-2-Piperidylmethanol Derivatives

D. Mauleón, A. Delgado, F. Perez, 1988 .

A New and Diastereoselective Synthesis of threo-Aryl-2-piperidylmethanol Derivatives.

D. Mauleón, A. Delgado, F. Perez, 1989 .

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

C. Bedia, A. Llebaria, J. Casas, 2008, Chemistry and physics of lipids.

Nucleophile-dependent stereodivergence in the Pd-catalyzed intramolecular cyclization of 2-(p-tolylsulfinyl)allylacetates

A. Roig, E. Molins, A. Llebaria, 1999 .