L. K. Gavrin

发表

Recent developments in targeting protein misfolding diseases.

R. Denny, E. Saiah, L. K. Gavrin, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

J. Telliez, J. Cuozzo, Lih-Ling Lin, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of pyrazolo[1,5 -α ]pyrimidinone regioisomers

J. McKew, G. Ciszewski, D. Cole, 2007 .

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.

J. Telliez, D. Powell, J. Cuozzo, 2007, Bioorganic & medicinal chemistry.

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

J. Telliez, A. Gopalsamy, G. Ciszewski, 2005, Bioorganic & medicinal chemistry letters.

Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.

Annette Sievers, Désirée H H Tsao, L. Mosyak, 2010, Journal of medicinal chemistry.

Approaches to discover non-ATP site kinase inhibitors

Eddine Saiah, E. Saiah, Lori Krim Gavrin, 2013 .

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

L. Leventhal, E. Koury, K. Burroughs, 2008, Journal of medicinal chemistry.

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.

K. Burroughs, D. Deecher, P. Mahaney, 2010, ACS medicinal chemistry letters.

Small molecules that target protein misfolding.

R. Denny, E. Saiah, L. K. Gavrin, 2012, Journal of medicinal chemistry.