J. Parsels

发表

Translation of DNA damage response inhibitors as chemoradiation sensitizers from the laboratory to the clinic.

A. Rehemtulla, T. Lawrence, H. Willers, 2021, International journal of radiation oncology, biology, physics.

Death in Human Colon Cancer Cells Correlates with Premature Mitotic Entry and Clonogenic-Deoxyuridine-Induced cdc 25 A Accumulation ′ 5-Fluoro-2 Updated

J. Maybaum, L. A. Parsels, J. Parsels, 2004 .

5-Fluoro-2′-Deoxyuridine-Induced cdc25A Accumulation Correlates with Premature Mitotic Entry and Clonogenic Death in Human Colon Cancer Cells

J. Maybaum, L. A. Parsels, J. Parsels, 2004, Cancer Research.

Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair12

T. Lawrence, J. Maybaum, Mary A Davis, 2015, Neoplasia.

Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1

T. Lawrence, J. Maybaum, M. Morgan, 2011, Cell cycle.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

T. Lawrence, J. Maybaum, S. Zabludoff, 2011, Neoplasia.

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation123

T. Lawrence, Yi Sun, Qiang Zhang, 2016, Neoplasia.

Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine.

T. Lawrence, J. Maybaum, M. Morgan, 2005, Cancer research.

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Daria M. Tanska, T. Lawrence, J. Maybaum, 2018, Cell cycle.

Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer.

M. Schipper, T. Lawrence, J. Maybaum, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Cancer Therapy : Preclinical Sensitization of Pancreatic Cancer to Chemoradiation by the Chk 1 Inhibitor MK 8776

Daria M. Tanska, T. Lawrence, J. Maybaum, 2013 .

Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

Daria M. Tanska, T. Lawrence, J. Maybaum, 2016, Cell cycle.

Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells

J. Maybaum, E. Radany, L. A. Parsels, 1998, Cancer Chemotherapy and Pharmacology.

Cytochrome c Depletion upon Expression of Bcl-XS*

A. Rehemtulla, J. Fridman, J. Maybaum, 2001, The Journal of Biological Chemistry.

Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype.

R. Zellars, M. Clarke, T. Lawrence, 1997, Molecular pharmacology.

Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.

Alnawaz Rehemtulla, Shengping Li, Theodore S Lawrence, 2003, Cancer research.

Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts.

A. Rehemtulla, T. Lawrence, A Rehemtulla, 2000, Cancer research.

Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair

T. Lawrence, Yi Sun, J. Maybaum, 2013, Clinical Cancer Research.

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis.

C. Burant, F. Feng, T. Lawrence, 2017, Cancer research.

Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner

T. Lawrence, Qiang Zhang, W. Zou, 2021, Molecular Cancer Research.

Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer

Daria M. Tanska, T. Lawrence, C. Canman, 2020, Molecular Cancer Therapeutics.

Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression

F. Maley, J. Maybaum, M. Kowalski, 2000, Cancer Gene Therapy.

Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776

Daria M. Tanska, T. Lawrence, J. Maybaum, 2013, Clinical Cancer Research.

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Jonathan Maybaum, Daria M. Tanska, Theodore S Lawrence, 2009, Molecular Cancer Therapeutics.

The Relationship of Premature Mitosis to Cytotoxicity in Response to Checkpoint Abrogation and Antimetabolite Treatment

T. Lawrence, J. Maybaum, M. Morgan, 2006, Cell cycle.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

T. Lawrence, J. Maybaum, S. Zabludoff, 2011, Neoplasia.

Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy.

T. Lawrence, Qiang Zhang, M. Pasca di Magliano, 2019, Cancer research.

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

Daria M. Tanska, T. Lawrence, J. Maybaum, 2011, Clinical Cancer Research.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Jonathan Maybaum, Diane M Simeone, Theodore S Lawrence, 2010, Cancer research.

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

T. Lawrence, M. O’Connor, J. Maybaum, 2017, Molecular Cancer Research.

DNA-PK inhibition and radiation promote anti-tumoral immunity through RNA Polymerase III in pancreatic cancer.

T. Lawrence, Qiang Zhang, T. Frankel, 2022, Molecular cancer research : MCR.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

T. Lawrence, C. Canman, J. Maybaum, 2010, Cancer research.