R. Kimbell

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ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer.

A. Jackman, T. Stephens, M. Azab, 1995, European journal of cancer.

Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations.

A. Jackman, R. Kimbell, H. Ford, 1999, European journal of cancer.

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

G. Aherne, L. Brunton, G. Jansen, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines.

G. Aherne, A. Jackman, A. Hardcastle, 1995, European journal of cancer.

Increased abundance of a normal cell mRNA sequence accompanies the conversion of rat mammary cuboidal epithelial cells to elongated myoepithelial-like cells in culture.

P. Rudland, R. Barraclough, R. Kimbell, 1984, Nucleic acids research.

A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.

M. Walton, G. Aherne, L. Brunton, 2002, Biochimica et biophysica acta.

Differential control of mRNA levels for Thy‐1 antigen and laminin in rat mammary epithelial and myoepithelial‐like cells

P. Rudland, R. Barraclough, R. Kimbell, 1987, Journal of cellular physiology.

Control of type IV collagen production in rat mammary epithelial and myoepithelial‐like cells

P. Rudland, R. Barraclough, R. Kimbell, 1986, Journal of cellular physiology.

Carboxylic acid bioisosteres of γ-linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

A. Jackman, V. Bavetsias, R. Kimbell, 1996 .

Loss of basement membrane deposits and development of invasive potential by virally‐transformed rat mammary cells are independent of collagenase production

B. Gusterson, P. Rudland, P. Monaghan, 1987, International journal of cancer.

Dissociation of basement membrane protein deposition and cell spreading in virally transformed rat mammary myoepithelial cells.

P. Monaghan, R. Kimbell, M. Warburton, 1986, Journal of cell science.

Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug

A. Jackman, H. Miyachi, Hiroyuki Kobayashi, 2005, Journal of Cancer Research and Clinical Oncology.

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.

L. Kèlland, G. Aherne, A. Jackman, 1995, British Journal of Cancer.

The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694.

A. Jackman, W. Gibson, R. Kimbell, 1993, Advances in experimental medicine and biology.

Role of fibronectin in the organisation of the cytoskeleton during the spreading of rat mammary epithelial cells.

J. Aitken, R. Kimbell, M. Warburton, 1992, Cell biology international reports.

Characterisation of chondroitin/dermatan sulphate proteoglycans synthesised by rat mammary myoepithelial and fibroblastic cell lines.

P. Monaghan, N. Perusinghe, R. Kimbell, 1992, Biochimica et biophysica acta.

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.

L. Brunton, A. Jackman, R. Kimbell, 1995, Anti-cancer drug design.

Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.

A. Jackman, L. Hennequin, R. Kimbell, 1996, Journal of medicinal chemistry.

Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.

A. Jackman, L. Hennequin, R. Kimbell, 1999, Journal of medicinal chemistry.

Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).

A. Jackman, V. Bavetsias, R. Kimbell, 2000, Journal of medicinal chemistry.

Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.

A. Jackman, A. Calvert, R. Kimbell, 1995, Journal of medicinal chemistry.

Synthesis of novel quinazoline-based antifolates with modified glutamate side chains as potential inhibitors of thymidylate synthase and antitumour agents

A. Jackman, V. Bavetsias, R. Kimbell, 1997 .

Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).

A. Jackman, V. Bavetsias, W. Gibson, 1997, Journal of medicinal chemistry.

Quinazoline Antifolate Thymidylate Synthase Inhibitor That Is a Potent Inhibitor of LI 210 Tumor Cell Growth in Vitro and in Vivo : A New Agent for Clinical Study 1

I. Judson, A. Jackman, A. Calvert, 2006 .

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.

A. Jackman, W. Ward, R. Kimbell, 1992, Biochemical pharmacology.

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

I. Judson, A. Jackman, A. Calvert, 1991, Cancer research.

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates.

R. Moran, A. Jackman, A. Calvert, 1991, Advances in enzyme regulation.

Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)†,‡

A. Jackman, V. Bavetsias, W. Gibson, 1996 .

A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

L. Brunton, A. Jackman, J. Titley, 1999, British Journal of Cancer.

Antifolates in Combination Therapy

S. Ackland, R. Kimbell, 1999 .

Biological Activity and Intracellular Metabolism of ZD1694 in Human Leukemia Cell Lines with Different Resistance Mechanisms to Antifolate Drugs

A. Jackman, H. Miyachi, Hiroyuki Kobayashi, 1996, Japanese journal of cancer research : Gann.

The influence of drug‐exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells

A. Jackman, H. Miyachi, Hiroyuki Kobayashi, 1996, International journal of cancer.

The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.

L. Brunton, A. Jackman, R. Kimbell, 1994, Advances in experimental medicine and biology.

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.

L. Brunton, A. Jackman, V. Bavetsias, 1995, Anti-cancer drug design.