N. Barlow

发表

Enhanced Cytotoxicity through Conjugation of a "Clickable" Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide.

S. Ferrari, G. Gasser, B. Graham, 2014, ACS medicinal chemistry letters.

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

P. Thompson, N. Barlow, 2020, Frontiers in Pharmacology.

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).

J. Åqvist, H. Gutiérrez‐de‐Terán, A. Hallberg, 2020, RSC medicinal chemistry.

Partly-PEGylated Poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers.

L. Kaminskas, B. Boyd, G. Krippner, 2009, Journal of pharmaceutical sciences.

Dynamic Binding Mode of a Synaptotagmin-1-SNARE Complex in Solution

T. Südhof, J. Rizo, A. Cavalli, 2015, Nature Structural &Molecular Biology.

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.

N. Bunnett, L. Aurelio, B. Graham, 2017, Bioorganic & medicinal chemistry letters.

Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate

B. Graham, K. Tuck, N. Barlow, 2012 .

Effect of Linker Length and Composition on Heterobivalent Ligand‐Mediated Receptor Cross‐Talk between the A1 Adenosine and β2 Adrenergic Receptors

P. Scammells, N. Barlow, S. Baker, 2013, ChemMedChem.

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

R. Norton, R. Law, P. Thompson, 2018, ACS chemical biology.

Membrane Permeating Macrocycles: Design Guidelines from Machine Learning

T. Le, R. Norton, P. Thompson, 2022, J. Chem. Inf. Model..

The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest

A. Konkayev, V. Dahl, N. Barlow, 2019, BMC Anesthesiology.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Pierangelo Geppetti, Martin J. Scanlon, Christopher J. H. Porter, 2017, Science Translational Medicine.

Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate.

R. Norton, P. Thompson, C. Nowell, 2022, Bioorganic chemistry.

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins.

Thomas Huber, Gottfried Otting, G. Otting, 2013, Bioconjugate chemistry.

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra.

Thomas Huber, Guido Pintacuda, Gottfried Otting, 2011, Bioconjugate chemistry.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain*

Nigel W. Bunnett, S. Vanner, N. Bunnett, 2015, The Journal of Biological Chemistry.

Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4*

Erik Lindström, Peter McIntyre, Nigel W. Bunnett, 2014, The Journal of Biological Chemistry.

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2

D. Fairlie, N. Bunnett, P. Mclean, 2016, British journal of pharmacology.

Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

C. Pouton, P. Thompson, D. Chalmers, 2023, Journal of medicinal chemistry.

Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2

S. E. Stewart, M. Hollenberg, A. Suhrbier, 2022, PloS one.

Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK

J. Newman, T. Peat, O. Dolezal, 2013, PloS one.

1 Dynamic Synaptotagmin-1-SNARE Complex Binding Mode in Solution

T. Südhof, J. Rizo, A. Cavalli, 2015 .

Improving membrane permeation in the beyond rule-of-five space by using prodrugs to mask hydrogen bond donors.

R. Norton, P. Thompson, D. Chalmers, 2020, ACS chemical biology.

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

J. Baell, Zhong-Chang Wang, J. Newman, 2014, Journal of medicinal chemistry.

Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

E. Arnold, M. Gunzburg, N. Sluis-Cremer, 2023, Molecules.

Assessing the cellular toxicity of peptide inhibitors of intracellular protein-protein interactions by microinjection.

R. Norton, C. Pouton, C. Nowell, 2020, Bioorganic & medicinal chemistry.

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Y. Nasser, N. Bunnett, E. Lindström, 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins.

G. Otting, T. Huber, K. Ozawa, 2013, Bioconjugate chemistry.

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

J. Baell, Zhong-Chang Wang, T. Peat, 2018, Chemistry.