J. O'Brien

发表

Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.

Jonathan A. Kitchen, T. Gunnlaugsson, D. Williams, 2013, Chemical communications.

Cyclen based lanthanide ion ribonuclease mimics: the effect of pyridine cofactors upon phosphodiester HPNP hydrolysis

T. Gunnlaugsson, T. McCabe, P. Kruger, 2005 .

Effect on pKa of metal-bound water molecules in lanthanide ion-induced cyclen "cavities".

T. Gunnlaugsson, M. Nieuwenhuyzen, D. Brougham, 2004, Organic letters.

Synthesis, structural and biological evaluation of GlyAla based lanthanide macrocyclic conjugates as supramolecular ribonuclease mimics

T. Gunnlaugsson, M. Nieuwenhuyzen, R. Davies, 2003 .

Test purchase, identification and synthesis of 2-amino-1-(4-bromo-2, 5-dimethoxyphenyl)ethan-1-one (bk-2C-B).

B. Twamley, S. Brandt, J. O'Brien, 2015, Drug testing and analysis.

Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) and its iodo analogue bk-2C-I.

E. A. Gardner, S. Brandt, J. O'Brien, 2018, Drug testing and analysis.

Identification and characterization of an imidazolium by-product formed during the synthesis of 4-methylmethcathinone (mephedrone).

B. Twamley, S. Brandt, J. O'Brien, 2015, Drug testing and analysis.

Glycine-alanine conjugated macrocyclic lanthanide ion complexes as artificial ribonucleases

T. Gunnlaugsson, J. O'Brien, Sinead Mulready, 2002 .

The effect of the linker size in C2-symmetrical chiral ligands on the self-assembly formation of luminescent triple-stranded di-metallic Eu(iii) helicates in solution.

C. McCoy, T. Gunnlaugsson, Komala Pandurangan, 2018, Dalton transactions.

Metal-directed synthesis of enantiomerially pure dimetallic lanthanide luminescent triple-stranded helicates.

C. McCoy, T. Gunnlaugsson, R. Peacock, 2009, Journal of the American Chemical Society.

The Psilocin (4‐hydroxy‐N,N‐dimethyltryptamine) and Bufotenine (5‐hydroxy‐N,N‐dimethyltryptamine) Case: Ensuring the Correct Isomer has Been Identified

J. O'Brien, P. Kavanagh, Brian Talbot, 2020, Journal of forensic sciences.

Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents

T. Gunnlaugsson, D. Brougham, J. K. Molloy, 2020 .

β-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria

M. Devocelle, T. Smyth, H. Humphreys, 2012 .

The application of chiroptical spectroscopy (circular dichroism) in quantifying binding events in lanthanide directed synthesis of chiral luminescent self-assembly structures

Jonathan A. Kitchen, T. Gunnlaugsson, B. Twamley, 2014, Chemical science.

The syntheses and characterization 3β-(4-fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3α isomer.

J. O'Brien, P. Kavanagh, S. McDermott, 2012, Drug testing and analysis.

Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.

D. Williams, M. Meegan, S. Cloonan, 2010, Bioorganic & medicinal chemistry.

Synthesis, analytical characterization, and monoamine transporter activity of the new psychoactive substance 4-methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers.

B. Twamley, S. Brandt, D. Walther, 2018, Drug testing and analysis.

Forensic analysis of P2P derived amphetamine synthesis impurities: identification and characterization of indene by-products.

B. Twamley, S. Brandt, J. O'Brien, 2017, Drug testing and analysis.

Colorimetric sensing of anions in aqueous solution using a charge neutral, cleft-like, amidothiourea receptor: tilting the balance between hydrogen bonding and deprotonation in anion recognition.

T. Gunnlaugsson, T. McCabe, J. O'Brien, 2008, Organic & biomolecular chemistry.

Visiting Sick People: Is It Really Detrimental to Our Health?

D. Pontier, D. Fouchet, J. O'Brien, 2008, PloS one.

A folded [2 × 2] metallo-supramolecular grid from a bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand.

M. Ruether, T. Gunnlaugsson, J. O'Brien, 2017, Dalton transactions.

Electrostatic interactions play an essential role in the binding of oleic acid with α‐lactalbumin in the HAMLET‐like complex: A study using charge‐specific chemical modifications

C. Svanborg, J. O'Brien, S. Min, 2013, Proteins.

Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni').

N. Dempster, B. Twamley, Kuldip Singh, 2014, Drug testing and analysis.

Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR).

B. Twamley, S. Brandt, J. Partilla, 2015, Drug testing and analysis.

Asymmetric acyl-transfer promoted by readily assembled chiral 4-N,N-dialkylaminopyridine derivatives.

T. McCabe, G. Watson, S. Connon, 2006, Organic & biomolecular chemistry.

The identification of an impurity product, 4,6-dimethyl-3,5-diphenylpyridin-2-one in an amphetamine importation seizure, a potential route specific by-product for amphetamine synthesized by the APAAN to P2P, Leuckart route.

J. O'Brien, P. Kavanagh, J. Power, 2014, Forensic science international.

Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog.

B. Twamley, S. Brandt, J. O'Brien, 2017, Drug testing and analysis.

Synthetic Reactions of 2-(2-Amino-3-cyano-4H-(1)benzopyran-4-yl) propane-1,3-dinitrile with Reactive Methylene Compounds.

J. O'Brien, T. Mcmurry, C. N. O'callaghan, 1995 .

Synthetic reactions of 2-(2-amino-3-cyano-4H-[1]benzopyran-4-yl)propane-1,3-dinitrile with reactive methylene compounds

J. O'Brien, T. Mcmurry, C. N. O'callaghan, 1995 .

Sulphide as a leaving group: highly stereoselective bromination of alkyl phenyl sulphides† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic characterization for all new compounds, including details of NMR experiments and racemisation study. See DOI: 10

Mauro F. A. Adamo, M. Ruether, H. Ibrahim, 2019, Chemical science.

Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate.

T. Gunnlaugsson, A. P. Davis, J. O'Brien, 2005, Organic & biomolecular chemistry.

Fluorescent sensing of pyrophosphate and bis-carboxylates with charge neutral PET chemosensors.

T. Gunnlaugsson, A. P. Davis, J. O'Brien, 2002, Organic letters.

Isomerisation of benzopyran-2-imines in [2H6]dimethyl sulfoxide

J. O'Brien, T. Mcmurry, C. N. O'callaghan, 1998 .

The synthesis, N-alkylation and epimerisation study of a phthaloyl derived thiazolidine

T. Gunnlaugsson, T. McCabe, Emma B. Veale, 2008 .

Identification of (2-aminopropyl)indole positional isomers in forensic samples.

K. Scott, J. O'Brien, P. Kavanagh, 2014, Drug testing and analysis.

Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β‐Lactams

M. Meegan, N. O’Boyle, Cristina Trujillo, 2022, ChemistryOpen.

An approach to shortening the timeframe between the emergence of new compounds on the drugs market and the availability of reference standards: The microscale syntheses of nitrazolam and clonazolam for use as reference materials, utilizing polymer-supported reagents.

Brendan Twamley, Geraldine Dowling, Pierce V. Kavanagh, 2018, Drug testing and analysis.

The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine.

E. A. Gardner, K. Scott, J. O'Brien, 2014, Drug testing and analysis.

Reduction of dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) by photolysis in ethanol solution.

J. Kelly, C. Long, A. Selmi, 2005, Chemical communications.

Lanthanide directed self-assembly of highly luminescent supramolecular "peptide" bundles from α-amino acid functionalized 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) ligands.

Jonathan A. Kitchen, T. Gunnlaugsson, R. Peacock, 2015, Inorganic chemistry.

The identification of 4-methylamphetamine and its synthesis by-products in forensic samples.

J. O'Brien, P. Kavanagh, S. McDermott, 2013, Forensic science international.

Self-assembly of chiral luminescent lanthanide coordination bundles.

T. Gunnlaugsson, T. McCabe, P. Kruger, 2007, Journal of the American Chemical Society.

Fixing the Conformation of Calix[4]arenes: When Are Three Carbons Not Enough?

C. Macdonald, S. E. Matthews, S. Vidal, 2018, Chemistry.

Elucidating Atropisomerism in Nonplanar Porphyrins with Tunable Supramolecular Complexes

M. Senge, D. Gibbons, Karolis Norvaiša, 2020, Chemistry.

Thermomorphic metal scavengers: A synthetic and multinuclear NMR study of highly fluorinated ketones and their application in heavy metal removal

R. Baker, T. McCabe, J. O'Brien, 2010 .

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers.

Brian Talbot, Brendan Twamley, Geraldine Dowling, 2017, Drug testing and analysis.

Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone.

B. Twamley, S. Brandt, J. Partilla, 2017, Drug testing and analysis.

Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo and (±)-erythro diastereomers.

B. Twamley, S. Brandt, J. Partilla, 2017, Drug testing and analysis.

Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers.

J. Wallach, S. Brandt, J. O'Brien, 2016, Drug testing and analysis.

NMR studies on mechanism of isomerisation of fructose 6-phosphate to glucose 6-phosphate catalysed by phosphoglucose isomerase from Thermococcus kodakarensis.

M. Ruether, K. H. Mok, N. Rashid, 2016, Bioorganic chemistry.

Unexpected Intramolecular Phosphite‐Mediated Amide Coupling To Yield 3,5‐Dioxo‐1‐Piperazines

B. Twamley, A. R. McDonald, J. O'Brien, 2021, ChemistrySelect.

The analysis of substituted cathinones. Part 3. Synthesis and characterisation of 2,3-methylenedioxy substituted cathinones.

Cora O'Donnell, Rachel Christie, Pierce Kavanagh, 2012, Forensic science international.

The synthesis and characterization N-methyl-3-phenyl-norbornan-2-amine (Camfetamine™).

J. O'Brien, P. Kavanagh, S. McDermott, 2013, Drug testing and analysis.

The syntheses of 1-(2-thienyl)-2-(methylamino) propane (methiopropamine) and its 3-thienyl isomer for use as reference standards.

J. O'Brien, P. Kavanagh, D. Angelov, 2013, Drug testing and analysis.

Photochemical [2 + 2] cycloaddition reactions of 6-alkenyl-3-phenylcyclohex-2-en-1-ones: using biradical conformation control to account for exceptions to the "rule of five".

T. McCabe, N. Geraghty, S. Draper, 2011, Organic & biomolecular chemistry.

Preparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure.

A. Healy, T. McCabe, O. Corrigan, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The analysis of amphetamine-like cathinone derivatives using positive electrospray ionization with in-source collision-induced dissociation.

J. O'Brien, P. Kavanagh, S. McDermott, 2012, Rapid communications in mass spectrometry : RCM.

The analysis of substituted cathinones. Part 1: chemical analysis of 2-, 3- and 4-methylmethcathinone.

J. O'Brien, P. Kavanagh, S. McDermott, 2011, Forensic science international.

The synthesis and characterization of the 'research chemical' N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer.

B. Twamley, S. Brandt, J. O'Brien, 2016, Drug testing and analysis.

alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.

Maria Trulsson, Y. Lim, C. Svanborg, 2009, Journal of molecular biology.

Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma

D. Williams, M. Meegan, B. Twamley, 2020, Pharmaceuticals.

THE ORGANIC PHOSPHORUS COMPOSITION OF AN IRISH GRASSLAND SOIL

H. Tunney, D. Jeffrey, D. Bourke, 2022, Biology and Environment: Proceedings of the Royal Irish Academy.

The analysis of substituted cathinones. Part 2: an investigation into the phenylacetone based isomers of 4-methylmethcathinone and N-ethylcathinone.

J. O'Brien, P. Kavanagh, S. McDermott, 2011, Forensic science international.

'Smoking' mephedrone: the identification of the pyrolysis products of 4-methylmethcathinone hydrochloride.

J. O'Brien, P. Kavanagh, S. McDermott, 2013, Drug testing and analysis.

Characterization of the pyrolysis products of methiopropamine.

E. A. Gardner, J. O'Brien, P. Kavanagh, 2014, Drug testing and analysis.

Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures.

A. Healy, T. McCabe, O. Corrigan, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.