A. Kharitonenkov

发表

Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21.

M. Drangova, A. Adams, C. Pin, 2015, Endocrinology.

Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion

U. Rescher, V. Gerke, A. Kharitonenkov, 2008, Journal of Cell Science.

PTP1D is a positive regulator of the prolactin signal leading to beta‐casein promoter activation.

A. Ullrich, P. Kelly, W. Vogel, 1996, The EMBO journal.

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.

P. Scherer, J. Brozinick, W. Holland, 2013, Cell metabolism.

FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.

K. Feingold, C. Grunfeld, A. Moser, 2012, Endocrinology.

FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

P. Arner, P. Mitchell, J. D. Dunbar, 2008, FEBS letters.

FGF21: The center of a transcriptional nexus in metabolic regulation.

A. Adams, A. Kharitonenkov, 2012, Current diabetes reviews.

Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies.

A. Adams, A. Kharitonenkov, P. Antonellis, 2014, Journal of animal science.

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.

R. Gimeno, A. Adams, Dennis P. Smith, 2015, Cell reports.

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

F. Neff, S. Keipert, M. Jastroch, 2015, Molecular metabolism.

Interplay between FGF21 and insulin action in the liver regulates metabolism.

M. Arumugam, C. Kahn, B. Emanuelli, 2014, The Journal of clinical investigation.

Photoperiodic regulation of FGF21 production in the Siberian hamster

P. Emmerson, K. Tsintzas, S. Cooper, 2014, Hormones and Behavior.

Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.

D. Schuppan, J. Flier, T. Lundåsen, 2014, Gastroenterology.

FGF21 is an Akt‐regulated myokine

Yuichi Akasaki, K. Walsh, Y. Izumiya, 2008, FEBS letters.

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

M. Eriksson, I. Hafström, B. Angelin, 2008, Cell metabolism.

Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity.

D. Wasserman, M. Michael, E. Berglund, 2009, Endocrinology.

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

S. Woods, R. Seeley, P. Pfluger, 2013, Diabetes.

FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

J. D. Dunbar, J. Hale, T. Coşkun, 2008, Journal of cellular physiology.

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes

R. DiMarchi, K. Gamble, Tanya H. Pierre, 2021, JCI insight.

Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21.

R. DiMarchi, Fa Liu, F. Brunel, 2020, ACS pharmacology & translational science.

FGF19 and FGF21: In NASH we trust

Saswata Talukdar, A. Kharitonenkov, 2020, Molecular metabolism.

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

R. DiMarchi, D. Perez-Tilve, S. Parlee, 2018, Molecular metabolism.

Fibroblast growth factor 21 night watch: advances and uncertainties in the field

R. DiMarchi, A. Kharitonenkov, 2017, Journal of internal medicine.

Photoperiodic regulation of FGF 21 production in the Siberian hamster 6 7 8

P. Emmerson, K. Tsintzas, S. Cooper, 2016 .

Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity.

R. Gimeno, A. Adams, R. Samms, 2016, Endocrinology.

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

J. Flier, E. Maratos-Flier, T. Bartness, 2015, Endocrinology.

Inventing new medicines: The FGF21 story☆

A. Adams, A. Kharitonenkov, 2013, Molecular metabolism.

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones.

A. Adams, T. Coşkun, A. Kharitonenkov, 2013, Molecular metabolism.

FGF21 Requires βklotho to Act In Vivo

A. Adams, T. Coşkun, A. Kharitonenkov, 2012, PloS one.

Circulating αKlotho influences phosphate handling by controlling FGF23 production.

E. Farrow, D. Burr, K. White, 2012, The Journal of clinical investigation.

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.

R. Gimeno, A. Adams, T. Coşkun, 2013, Molecular metabolism.

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

J. D. Dunbar, A. Adams, T. Coşkun, 2012, PloS one.

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

F. De Luca, Shufang Wu, A. Kharitonenkov, 2012, The Journal of Biological Chemistry.

Hormone-like fibroblast growth factors and metabolic regulation.

Y. C. Long, A. Kharitonenkov, 2011, Biochimica et biophysica acta.

FGF21 reloaded: challenges of a rapidly growing field

A. Kharitonenkov, P. Larsen, 2011, Trends in Endocrinology & Metabolism.

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.

B. Spiegelman, J. Flier, E. Maratos-Flier, 2011, Endocrinology.

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

J. Flier, E. Maratos-Flier, F. Fisher, 2010, Diabetes.

Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.

J. Flier, E. Maratos-Flier, A. Koester, 2009, Endocrinology.

FGFs and metabolism.

A. Kharitonenkov, 2009, Current opinion in pharmacology.

Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice.

E. Fazio, S. Chadi, C. Pin, 2009, Gastroenterology.

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

B. Spiegelman, J. Flier, Sandra Kleiner, 2012, Genes & development.

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

R. DiMarchi, A. Kharitonenkov, 2015, Trends in Endocrinology & Metabolism.

Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1.

R. Mehmood, C. Pin, A. Kharitonenkov, 2014, American journal of physiology. Endocrinology and metabolism.

Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.

J. Flier, A. Hollenberg, E. Maratos-Flier, 2014, Endocrinology.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity

K. Tsintzas, P. Barrett, F. Ebling, 2013, Journal of neuroendocrinology.

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

A. Deshmukh, D. Moller, J. Zierath, 2011, Diabetes/metabolism research and reviews.

FGF21: a novel prospect for the treatment of metabolic diseases.

A. Shanafelt, A. Kharitonenkov, 2009, Current opinion in investigational drugs.

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

J. Gromada, G. Sandusky, W. Wente, 2006, Diabetes.

to Ketosis Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation

J. Flier, E. Maratos-Flier, A. Koester, 2009 .

Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver.

P. Webb, Pumin Zhang, D. Sieglaff, 2015, The Journal of endocrinology.

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.

P. Emmerson, K. Tsintzas, S. Cooper, 2015, The Journal of endocrinology.

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

B. Hansen, V. Wroblewski, V. Reynolds, 2013, PloS one.

Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells

A. Ullrich, S. Tomic, R. Lammers, 1995, The Journal of Biological Chemistry.

Interaction of a synthetic peptide of the interferon alpha-2 C-terminal part with human blood leukocytes. Binding to peripheral blood mononuclear cells.

A. Danilkovitch, O. Kolosova, A. Kharitonenkov, 1991, FEBS letters.

Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression

R. Jockers, J. Dam, F. De Luca, 2013, The Journal of Biological Chemistry.

Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

M. Bruss, M. Hellerstein, A. Adams, 2014, PloS one.

Fibroblast activation protein (FAP) as a novel metabolic target

D. Drucker, M. Tschöp, R. DiMarchi, 2016, Molecular metabolism.

FGF21 drives a shift in adipokine tone to restore metabolic health

A. Adams, A. Kharitonenkov, 2013, Aging.

A family of proteins that inhibit signalling through tyrosine kinase receptors

A. Ullrich, Zhengjun Chen, J. Schilling, 1997, Nature.

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation (*)

A. Ullrich, M. Stein-Gerlach, Suhad Ali, 1995, The Journal of Biological Chemistry.

Epigenetic Reprogramming in Mist1−/− Mice Predicts the Molecular Response to Cerulein-Induced Pancreatitis

R. Mehmood, C. Pin, G. Varga, 2014, PloS one.

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling*

Kyoung-Jae Won, M. Lazar, D. Steger, 2016, The Journal of Biological Chemistry.

Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*)

A. Ullrich, M. White, J. Schnekenburger, 1995, The Journal of Biological Chemistry.

Fibroblast growth factor 21 corrects obesity in mice.

D. Moller, Yanyun Chen, T. Coşkun, 2008, Endocrinology.

FGF21 as a therapeutic reagent.

A. Kharitonenkov, Yang Zhao, J. Dunbar, 2012, Advances in experimental medicine and biology.

FGF-21 as a novel metabolic regulator.

J. Gromada, G. Sandusky, F. Mehrbod, 2005, The Journal of clinical investigation.

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes.

H. Fu, D. Moller, J. Chien, 2013, Cell metabolism.

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

Li-Qun Zhang, Shu Q. Liu, Y. Li, 2013, Scientific Reports.

Different roles of N‐ and C‐ termini in the functional activity of FGF21

D. Driver, C. Dickinson, A. Kharitonenkov, 2009, Journal of cellular physiology.

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

Yun-Fei Chen, G. Etgen, B. Hansen, 2007, Endocrinology.

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

J. Gromada, G. Sandusky, W. Wente, 2006, Diabetes.

Plasma FGF21 is elevated by the intense lipid mobilization of lactation.

K. Harvatine, A. Kharitonenkov, Christine C. Cheng, 2011, Endocrinology.

Inhibition of T Cell Antigen Receptor Signaling by VHR-related MKPX (VHX), a New Dual Specificity Phosphatase Related to VH1 Related (VHR)*

A. Godzik, A. Alonso, T. Mustelin, 2002, The Journal of Biological Chemistry.

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

Christopher C. Frye, Tamer Coskun, J. M. Beals, 2013, PloS one.

Molecular determinants of FGF‐21 activity—synergy and cross‐talk with PPARγ signaling

F. Mehrbod, T. Noblitt, J. Moyers, 2007, Journal of cellular physiology.

Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism.

A. Adams, A. Kharitonenkov, F. B. Hillgartner, 2018, The Journal of nutrition.

Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice.

F. De Luca, Shufang Wu, A. Kharitonenkov, 2012, Endocrinology.

Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain.

A. Ullrich, N. Møłler, R. Lammers, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans

B. Angelin, T. Krusenstjerna-Hafstrøm, C. Höybye, 2013, Journal of internal medicine.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

L. Guarente, Mengwei Zang, Amber J. Giles, 2014, Gastroenterology.

Fibroblast Growth Factor-21 as a Therapeutic Agent for Metabolic Diseases

A. Shanafelt, A. Kharitonenkov, 2012, BioDrugs.

Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ε (*)

A. Ullrich, R. Lammers, N. Møller, 1995, The Journal of Biological Chemistry.

Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).

Xingguo Cheng, Jie Liu, C. Klaassen, 2014, Toxicology and applied pharmacology.

Fibroblast Growth Factor 21 as a Novel Metabolic Regulator

A. Kharitonenkov, R. Micanovic, J. Dunbar, 2011 .

Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates.

A. Kharitonenkov, Haixia Zou, Yuanyuan Zhang, 2023, Cell metabolism.

Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver

A. Xu, A. Kharitonenkov, Ranyao Yang, 2021, The Journal of clinical endocrinology and metabolism.