N. Jagerovic

发表

TRIFLUOROMETHYL AND PERFLUOROALKYL DERIVATIVES OF AZOLES. A REVIEW

J. Elguero, A. Fruchier, N. Jagerovic, 1995 .

Recent advances in cannabinoid receptor agonists and antagonists

P. Goya, N. Jagerovic, 2000 .

The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors

R. Franco, Gemma Navarro, P. Morales, 2022, Frontiers in Pharmacology.

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**

L. Pardo, R. Franco, Gemma Navarro, 2020, Chemistry.

Antitumor Cannabinoid Chemotypes: Structural Insights

P. Morales, N. Jagerovic, 2019, Front. Pharmacol..

Synthesis of a novel CB2 cannabinoid-porphyrin conjugate based on an antitumor chromenopyrazoledione

J. Fernández-Ruiz, P. Morales, N. Jagerovic, 2017 .

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor

L. Pardo, R. Franco, Gemma Navarro, 2020, Chemistry.

Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update

P. Morales, P. Goya, N. Jagerovic, 2016, Expert opinion on therapeutic patents.

Synthesis and molecular structure of 3-(2-benzyloxy-6-hydroxyphenyl)-5-styrylpyrazoles. Reaction of 2-styrylchromones and hydrazine hydrate

J. Elguero, J. Cavaleiro, A. Llamas-Saiz, 1999 .

Anti‐obesity efficacy of LH‐21, a cannabinoid CB1 receptor antagonist with poor brain penetration, in diet‐induced obese rats

F. Bermúdez-Silva, M. Macías-González, F. Pavón, 2012, British journal of pharmacology.

Synthesis and molecular structure of new O/N/O ligands: Bis-phenol-pyridine and bis-phenol-pyrazole

J. Elguero, J. Cavaleiro, A. Llamas-Saiz, 1997 .

Central Versus Peripheral Antagonism of Cannabinoid CB1 Receptor in Obesity: Effects of LH‐21, a Peripherally Acting Neutral Cannabinoid Receptor Antagonist, in Zucker Rats

F. Bermúdez-Silva, F. Pavón, A. Serrano, 2008, Journal of neuroendocrinology.

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21

F. Pavón, A. Serrano, A. Cippitelli, 2006, Neuropharmacology.

Aromatic propellenes. Part 1. NMR spectroscopy, X-ray crystal and molecular structure of hexa(3,5-dimethylpyrazol-1-yl)benzene

J. Elguero, A. Llamas-Saiz, C. Foces-Foces, 1995 .

4-NITROPYRAZOLE : A NITROGEN OR AN OXYGEN BASE IN THE GAS PHASE?

J. Abboud, M. Yáñez, J. Elguero, 1999 .

Efficient Syntheses of New Classes of Regiochemically Pure Benzoporphyrin Derivatives.

T. Dougherty, Kevin M Smith, R. Pandey, 2010 .

Synthesis and opioid activity of new fentanyl analogs.

L. Callado, C. Goicoechea, Carolina Cano, 2002, Life sciences.

Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.

J. Elguero, L. Callado, J. Meana, 2002, Bioorganic & medicinal chemistry.

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

J. Elguero, S. García‐Granda, M. Macías-González, 2008, Bioorganic & medicinal chemistry.

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review

P. Morales, P. Goya, N. Jagerovic, 2016, Cannabis and cannabinoid research.

A solid-state NMR, X-ray diffraction, and ab initio computational study of hydrogen-bond structure and dynamics of pyrazole-4-carboxylic acid chains.

J. Elguero, U. Langer, I. Alkorta, 2001, Journal of the American Chemical Society.

Ghrelin-Induced Orexigenic Effect in Rats Depends on the Metabolic Status and Is Counteracted by Peripheral CB1 Receptor Antagonism

F. R. de Fonseca, P. Goya, M. Ramírez-López, 2013, PloS one.

Molecular structure of 4-(3,5-dimethylpyrazol-1-yl)benzoic acid trifluoroacetate

J. Elguero, C. Cativiela, I. Sobrados, 1996 .

Gas‐phase (ion cyclotron resonance spectrometric) and solid‐state (crystallographic) studies of highly substituted pyrazoles

J. Abboud, J. Elguero, R. Notario, 1996 .

Molecular structure of 4-p-hydroxyphenyl-3,5-dimethylpyrazole monohydrate

J. Elguero, C. Cativiela, J. Serrano, 1996 .

NEW SYNTHETIC APPROACHES TO CONDENSED PYRIDAZINONES : ALKYLPYRIDAZINYL CARBONITRILES AS BUILDING BLOCKS FOR THE SYNTHESIS OF CONDENSED PYRIDAZINONES

J. Elguero, F. Al-Omran, M. H. Elnagdi, 1995 .

Synthesis, spectroscopic and electrochemical properties of tetrazolatomanganese(III) porphyrins

Y. H. Liu, K. Kadish, R. Guilard, 1995 .

Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity

R. Ciccocioppo, F. Rodríguez de Fonseca, J. Decara, 2021, Nutrients.

Palmitoleoylethanolamide Is an Efﬁcient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity

R. Ciccocioppo, J. Decara, N. Jagerovic, 2021 .

Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.

J. Holenz, J. Frigola, I. Alkorta, 2006, European journal of medicinal chemistry.

Reaction of 2-azidobenzothiazole and 1-azido-4-(3′,5′-dimethyl-1′-pyrazolyl)tetrafluorobenzene with [60]fullerene and characterization of the adducts by fast-atom bombardment mass spectrometry

J. Elguero, J. Aubagnac, N. Jagerovic, 1996 .

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.

M. García-Arencibia, J. Fernández-Ruiz, P. Morales, 2015, European journal of medicinal chemistry.

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites.

C. Dardonville, Gary J. Ryan, L. Callado, 2006, Bioorganic & medicinal chemistry.

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.

R. Franco, Gemma Navarro, C. Guaza, 2016, Journal of medicinal chemistry.

Chromenopyrazoles: Non‐psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties

J. Cumella, J. Fernández-Ruiz, P. Morales, 2012, ChemMedChem.

CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications.

P. Goya, N. Jagerovic, Cristina Fernández-Fernández, 2008, Current Topics in Medicinal Chemistry.

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

F. Rodríguez de Fonseca, J. Fernández-Ruiz, P. Morales, 2014, Drug design, development and therapy.

Dynamic NMR study of the mechanisms of double, triple, and quadruple proton and deuteron transfer in cyclic hydrogen bonded solids of pyrazole derivatives.

J. Elguero, H. Limbach, N. Jagerovic, 2004, Journal of the American Chemical Society.

Fentanyl and its analogue N-(1-phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide: 1H- and 13C-NMR spectroscopy, X-ray crystallography, and theoretical calculations.

J. Elguero, I. Alkorta, C. Foces-Foces, 2003, Chemical & pharmaceutical bulletin.

The Chromenopyrazole Scaffold in the Modulation of the Endocannabinoid System: A Broad Therapeutic Prospect

P. Morales, P. Goya, N. Jagerovic, 2018 .

Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure–Activity Relationship

J. Fernández-Ruiz, P. Morales, D. Hurst, 2022, ACS medicinal chemistry letters.

Novel approaches and current challenges with targeting the endocannabinoid system

P. Morales, N. Jagerovic, 2020, Expert opinion on drug discovery.

The Structure of Two 1-(Nitrophenyl)-Δ2-pyrazolines: a Crystallographic and Theoretical Study

J. Elguero, I. Alkorta, G. Yap, 2004 .

The search for proton mobility in solid pyrazoles: molecular and crystal structure of 3(5)-phenyl-4-bromo-5(3)-methylpyrazole

J. Elguero, A. Llamas-Saiz, C. Foces-Foces, 1999 .

Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.

J. Cumella, A. Gómez-Barrio, J. Escario, 2016, European journal of medicinal chemistry.

The structure of the agrochemical fungicidal 4-chloro-3-(3,5-dichlorophenyl)-1H-pyrazole (RPA 406194) and related compounds

V. Gerbaud, J. Elguero, N. Gabas, 2003 .

New Methods for the Synthesis of Cannabidiol Derivatives.

N. Jagerovic, L. Hernández‐Folgado, Laura Figuerola-Asencio, 2017, Methods in enzymology.

Synthetic cannabinoid quinones: preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity.

J. Fernández-Ruiz, P. Morales, M. C. Zúñiga, 2013, European journal of medicinal chemistry.

An experimental (NMR) and theoretical (GIAO) study of the tautomerism of benzotriazole in solution

J. Elguero, I. Alkorta, R. Claramunt, 2002 .

Study of the Structure of 1-Hydroxymethylindazole and 1-Hydroxymethylbenzotriazole by X-ray crystallography, Multinuclear NMR in Solution and DFT Calculations

J. Elguero, I. Alkorta, G. Yap, 2004 .

REGIOSELECTIVE SYNTHESIS OF THE HOMOCHIRAL LIGAND (4S,7R)-7,8,8-TRIMETHYL-4,5,6,7-TETRAHYDRO-4,7-METHANOINDAZOL-2-YL-INDAZOL-1'-YLMETHANE

P. Ballesteros, Ma Carmen López, N. Jagerovic, 1994 .

The Unusual Properties of 5‐Methyl‐4,5,6,7‐Tetrahydro‐1H‐Indazole in the Solid State

J. Elguero, C. Foces-Foces, M. Jimeno, 1997 .

Synthesis, structure (NMR and mass spectrometry) and conformational analysis of heterocyclic analogues of dibenzo[a,e]cycloocta-1,5-diene: 5,6,12,13-tetrahydrobispyrazolo[1,2-a:1′,2′-e][1,2,5,6]tetraazocinediium dihalides

J. Lavandera, J. Elguero, R. Claramunt, 1996 .

Synthesis and X-ray crystallographic study of 6,12-epiiminodibenzo[b,f][1,5]diazocines

P. Molina, J. Elguero, A. Arques, 1998 .

Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif.

F. Rodríguez de Fonseca, A. Serrano, I. Alkorta, 2004, Journal of medicinal chemistry.

19F,31P,1H NMR and X-ray crystallographic studies of (pentafluorophenyl)3−n(4-pyrazol-1-yl-2,3,5,6-tetrafluorophenyl)n=1,2,3 Phosphines

J. Elguero, S. García‐Granda, A. Fruchier, 1996 .

Multiple hydrogen bonds and tautomerism in naphthyridine derivatives

C. Alvarez-Rúa, J. Elguero, S. García‐Granda, 2004 .

THE COLORS OF C60 SOLUTIONS

J. Catalán, J. Elguero, N. Jagerovic, 1995 .

Microwave spectra and ab initio calculations of 1-nitropyrazole

M. Yáñez, J. Elguero, J. López, 1995 .

Basicity of 1-nitroaryl-4,5-dihydropyrazoles: pKa measurements and theoretical calculations

J. Elguero, R. Flammang, I. Alkorta, 2000 .

Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.

J. Flores, J. Fernández-Ruiz, P. Morales, 2015, Journal of medicinal chemistry.

1,2,4,5-Tetrazines vs. carboxylic acid dimers: Molecular chemistry vs. supramolecular chemistry

J. Elguero, L. Male, S. Teat, 2003 .

The molecular structure of 1,3-dimethyl-4-phenyl-1H-pyrazole-5-carboxylic acid

J. Elguero, I. Alkorta, N. Jagerovic, 2008 .

Superacid chemistry in the gas phase: Dissociative proton attachment to halomethanes

J. Abboud, J. Elguero, R. Notario, 1998 .

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking.

P. Fossa, E. Cichero, J. Fernández-Ruiz, 2017, European journal of medicinal chemistry.

Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.

M. García-Arencibia, J. Fernández-Ruiz, E. Muñoz, 2016, Pharmacological research.

Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally.

C. Goicoechea, N. Jagerovic, M. I. Martín, 2008, European journal of pharmacology.

Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives

C. Dardonville, R. Brun, Gary J. Ryan, 2009, Antimicrobial Agents and Chemotherapy.

Description of a Bivalent Cannabinoid Ligand with Hypophagic Properties

F. Bermúdez-Silva, F. Rodríguez de Fonseca, J. Fernández-Ruiz, 2013, Archiv der Pharmazie.

Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System

P. Morales, N. Jagerovic, Ana Lago-Fernandez, 2021, International journal of molecular sciences.

Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis

F. Ruíz-Pino, J. Fernández-Ruiz, E. de Lago, 2021, Molecules.

N-substituted-1,2,3-triazoles: synthesis, characterization and evaluation as cannabinoid ligands

J. Elguero, I. Alkorta, P. Goya, 2010 .

Advances Towards The Discovery of GPR55 Ligands.

P. Morales, N. Jagerovic, 2016, Current medicinal chemistry.

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

A. Irving, R. Chicharro, J. Fernández-Ruiz, 2016, Journal of medicinal chemistry.

Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism.

P. Morales, P. Goya, N. Jagerovic, 2018, Biochemical pharmacology.

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

R. Franco, Gemma Navarro, J. Fernández-Ruiz, 2016, Front. Neurosci..

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

E. Brǎiloiu, P. Morales, D. Hurst, 2020, Journal of medicinal chemistry.

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

P. Morales, P. Reggio, N. Jagerovic, 2017, Front. Pharmacol..

Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.

J. Elguero, A. Serrano, J. Fernández-Ruiz, 2013, Bioorganic & medicinal chemistry.

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators

P. Morales, P. Reggio, N. Jagerovic, 2022, Frontiers in Molecular Biosciences.

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

M. Zanda, P. Lazzari, P. Morales, 2016, European journal of medicinal chemistry.

Synthetic and Natural Derivatives of Cannabidiol.

P. Morales, N. Jagerovic, 2021, Advances in experimental medicine and biology.

Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening.

Ana Montero, L. Callado, J. Meana, 2002, Bioorganic & medicinal chemistry.

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1‐CB2 heteroreceptor complexes

R. Franco, Gemma Navarro, P. Morales, 2018, Biochemical pharmacology.

Targeting cannabinoid CB2 receptors in the Central Nervous System. Medicinal chemistry approaches and focus on neurodegenerative disorders affecting movement

J. Fernández-Ruiz, P. Morales, N. Jagerovic, 2016 .

Synthesis and Pharmacological Evaluation of Chlorinated N-Alkyl-3- and -5-(2-hydroxyphenyl)pyrazoles as CB1 Cannabinoid Ligands

J. Elguero, J. Cavaleiro, Artur M. S. Silva, 2007 .

Hydrogen Bond Compression during Triple Proton Transfer in Crystalline Pyrazoles. A Dynamic 15N NMR Study

J. Elguero, H. Limbach, N. Jagerovic, 1999 .

A structural study of pyrazole-1-carboxamides by X-ray crystallography and 13C CPMAS NMR spectroscopy

J. Elguero, I. Sobrados, A. Llamas-Saiz, 1999 .

Determination of the absolute configuration of 1,3,5-triphenyl-4,5-dihydropyrazole enantiomers by a combination of VCD, ECD measurements, and theoretical calculations

J. Elguero, I. Alkorta, N. Vanthuyne, 2011 .

Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.

C. Dardonville, L. Callado, J. Meana, 2004, Bioorganic & medicinal chemistry letters.

Fentanyl Derivatives Bearing Aliphatic Alkaneguanidinium Moieties: A New Series of Hybrid Molecules with Significant Binding Affinity for μ-Opioid Receptors and I2-Imidazoline Binding Sites.

C. Dardonville, L. Callado, J. Meana, 2004 .

SYNTHESIS AND 1H, 19F NMR SPECTROSCOPIC CHARACTERIZATION OF (PENTAFLUOROPHENYL)3-N(PYRAZOL-1-YL-TETRAFLUOROPHENYL)N=1,2 PORPHYRINS

J. Elguero, A. Fruchier, N. Jagerovic, 1995 .

Use of the chlorophyll derivative, purpurin-18, for syntheses of sensitizers for use in photodynamic therapy

Nadine Jagerovic, Kevin M. Smith, Kevin M Smith, 1993 .

Structure of a 4-nitroso-5-aminopyrazole and its salts: tautomerism, protonation, and E/Z isomerism.

J. Elguero, I. Alkorta, D. Sanz, 2003, The Journal of organic chemistry.

Photosensitization with derivatives of chlorin p6.

C. Gomer, D. Kessel, K. Woodburn, 1995, Journal of Photochemistry and Photobiology. B: Biology.

The X-ray crystal and molecular structure of 3,5-di- tert-butylpyrazole hydrochloride at 200 K

J. Elguero, C. Foces-Foces, N. Jagerovic, 1995 .

Solid state structure of NH-pyrazoles not easily amenable to crystal structure determinations: The case of 3(5)-phenyl-5(3)-methylpyrazole and 3,5-diphenyl-4-methylpyrazole

J. Elguero, H. Limbach, C. Foces-Foces, 1995 .

PACKING MODES IN EIGHT 3-ETHOXYCARBONYLPYRAZOLE DERIVATIVES. INFLUENCE OF THE SUBSTITUENTS ON THE CRYSTAL STRUCTURE AND ANNULAR TAUTOMERISM

J. Elguero, C. Foces-Foces, R. Claramunt, 1999 .

Solid-state structure of NH-pyrazolium hydrochlorides and hydrobromides by X-ray crystallography and CPMAS NMR

J. Elguero, C. Foces-Foces, R. Claramunt, 1997 .

15N NMR chemical shifts of NH‐pyrazoles in the solid state and in solution at low temperature

J. Elguero, H. Limbach, N. Jagerovic, 1994 .

Structure and Dynamics of 3,5-Di-tert-butylpyrazole Probed by Combined X-ray Crystallography and 15N Solid State NMR

J. Elguero, H. Limbach, C. Foces-Foces, 1995 .

STRUCTURE OF 3-NITROPYRAZOLE IN SOLUTION AND IN THE SOLID STATE

J. Elguero, M. Menéndez, A. Llamas-Saiz, 1997 .

HEXADECA(PYRASOL-1-YL)PHTHALOCYANINE : A SOLUBLE PHTALOCYANINE ABSORBING AT 780 NM

J. Elguero, A. Llamas-Saiz, I. Alkorta, 1996 .

Synthesis, spectroscopic and electrochemical characterization of different isomer types in tetrazolatoindium(III) porphyrins

K. Kadish, R. Guilard, N. Jagerovic, 1992 .

Crystal structure of 1,3,5-triphenyl-2-pyrazoline: a case of spontaneous resolution

J. Elguero, C. Foces-Foces, N. Jagerovic, 2001 .

Metalloporphyrins containing .sigma.-bonded nitrogen axial ligands. 1. Synthesis and characterization of indium(III) porphyrin complexes. Molecular structures of (4-phenyltetrazolato) and (5-methyltetrazolato)(2,3,7,8,12,13,17,18-octaethylporphinato)indium(III)

C. Lecomte, K. Kadish, P. Richard, 1991 .

Benzyl-1,2,4-triazoles as CB1 Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation

F. Rodríguez de Fonseca, P. Goya, J. Decara, 2016, International journal of medicinal chemistry.

Guanidinium and Aminoimidazolinium Derivatives of N‐(4‐Piperidyl)propanamides as Potential Ligands for μ Opioid and I2‐Imidazoline Receptors: Synthesis and Pharmacological Screening.

Ana Montero, L. Callado, J. Meana, 2002 .

Cannabinoids and neuropathic pain.

P. Goya, N. Jagerovic, L. Hernández‐Folgado, 2003, Mini reviews in medicinal chemistry.

Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.

J. Cumella, A. Gómez-Barrio, J. Escario, 2016, European journal of medicinal chemistry.

Theoretical study of cyameluric acid and related compounds

J. Elguero, I. Alkorta, N. Jagerovic, 2004 .

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

J. Elguero, S. García‐Granda, M. Macías-González, 2008, Bioorganic & medicinal chemistry.