Lukasz J. Bugaj

发表

Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics

Hana El-Samad, Andrew H. Ng, Taylor H. Nguyen, 2019, bioRxiv.

Interrogating cellular perception and decision making with optogenetic tools

Wendell A. Lim, Geoff P. O’Donoghue, W. Lim, 2017, The Journal of cell biology.

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

Jared E. Toettcher, W. Lim, J. Toettcher, 2018, Science.

Age‐Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis

D. Schaffer, H. Yousef, I. Conboy, 2015, Stem cells.

β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells

D. Schaffer, R. Kane, L. Bugaj, 2020, Proceedings of the National Academy of Sciences.

Optogenetic protein clustering and signaling activation in mammalian cells

Ravi S Kane, Lukasz J Bugaj, David V Schaffer, 2013, Nature Methods.

High-throughput multicolor optogenetics in microwell plates

Wendell A. Lim, Lukasz J. Bugaj, W. Lim, 2019, Nature Protocols.

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

D. Schaffer, H. Yousef, I. Conboy, 2015, Oncotarget.

Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor

B. Chow, L. Bugaj, Lukasz J. Bugaj, 2022, bioRxiv.

Modular engineering of cellular signaling proteins and networks.

Russell M Gordley, Wendell A Lim, Lukasz J Bugaj, 2016, Current opinion in structural biology.

Decoding of YAP levels and dynamics by pluripotency factors

O. Weiner, Nicholas C. Lammers, L. Bugaj, 2022, bioRxiv.

Dynamic Regulation of Mammalian Cell Signaling through Optical Protein Clustering

L. Bugaj, Lukasz J. Bugaj, 2014 .

Age‐associated Increase in Bmp Signaling In‐ Hibits Hippocampal Neurogenesis * Key Words. Adult Stem Cells @bullet Aging @bullet Neural Stem Cell @bullet Proliferation @bullet Neu‐ Rogenesis @bullet Stem Cell‐microenvironment Interactions @bullet Bmp Signaling

David, D. Schaffer, H. Yousef, 2022 .

Visual detection of submicroscopic protein clusters with a phase-separation-based fluorescent reporter

L. Bugaj, Lukasz J. Bugaj, T. Mumford, 2022, bioRxiv.

Oncogenic protein condensates modulate cell signal perception and drug tolerance

T. Bivona, L. Bugaj, Lukasz J. Bugaj, 2022, bioRxiv.

Vertebrate cells differentially interpret ciliary and extraciliary cAMP

Wan Li, J. Reiter, S. Choksi, 2021, Cell.

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve

A. Shoukas, L. Santhanam, K. Schuleri, 2012, European Journal of Applied Physiology.

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

A. Shoukas, Y. Oh, D. Christianson, 2009, Journal of applied physiology.

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.

A. Shoukas, L. Santhanam, J. Hare, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

D. Schaffer, R. Kane, M. Varedi, 2015, Nature Communications.

Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway

A. Shoukas, J. Hare, H. Champion, 2010, European Journal of Applied Physiology.

Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation

O. Weiner, Nicholas C. Lammers, Hernán G. García, 2023, Nature communications.

Single-component optogenetic tools for inducible RhoA GTPase signaling

B. Chow, Keisuke Yamada, Erin E. Berlew, 2021, bioRxiv.

Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor

B. Chow, Lukasz J. Bugaj, T. Mumford, 2022, bioRxiv.

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

Jared E. Toettcher, W. Lim, A. Sabnis, 2018, Science.

Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter

Lukasz J. Bugaj, T. Mumford, Diarmid Rae, 2024, bioRxiv.

Rapid optogenetic clustering in the cytoplasm with BcLOVclust.

Lukasz J. Bugaj, W. Benman, Zikang Huang, 2024, Journal of molecular biology.

Multiplexed dynamic control of temperature to probe and observe mammalian cells

Lukasz J. Bugaj, T. Mumford, W. Benman, 2024, bioRxiv.

Bringing next-generation therapeutics to the clinic through synthetic biology.

Lukasz J Bugaj, David V Schaffer, D. Schaffer, 2012, Current opinion in chemical biology.

Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation

B. Chow, Erin E. Berlew, L. Bugaj, 2020, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.