Dmitri A Pissarnitski

发表

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.

Zhiqiang Zhao, William J Greenlee, Murali Rajagopalan, 2007, Bioorganic & medicinal chemistry letters.

Solution-phase parallel synthesis of carbamates as gamma-secretase inhibitors.

J. Clader, Lixin Song, G. Terracina, 2008, Journal of combinatorial chemistry.

Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.

W. Greenlee, A. Stamford, H. Guzik, 2005, Bioorganic & medicinal chemistry letters.

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2008, Bioorganic & medicinal chemistry letters.

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

W. Greenlee, H. Guzik, J. Clader, 2007 .

Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6

Dmitri A Pissarnitski, 2006, Medicinal research reviews.

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.

J. Clader, G. Scapin, J. Voigt, 2016, Bioorganic & medicinal chemistry.

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Jinsong Hao, A. Stamford, G. Scapin, 2016, ACS medicinal chemistry letters.

SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

W. Greenlee, A. Stamford, R. Xu, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.

Lynn A. Hyde, W. Greenlee, Wei Zhou, 2012, ACS medicinal chemistry letters.

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

W. Greenlee, J. Clader, A. Nomeir, 2007 .

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Ruo Xu, Zhiqiang Zhao, Murali Rajagopalan, 2007 .

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Zhiqiang Zhao, Wei Li, William J. Greenlee, 2007 .

SAR of tricyclic sulfones as γ-secretase inhibitors

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2011 .

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

W. Greenlee, Mark D. McBriar, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.

Lynn A. Hyde, W. Greenlee, A. Palani, 2017, ACS medicinal chemistry letters.

Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

W. Greenlee, Xiaohong Zhu, A. Palani, 2012 .

Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists

Margaret S. Wu, M. Erion, S. Hollingsworth, 2022, Nature Communications.

Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists

Margaret S. Wu, M. Erion, S. Hollingsworth, 2021, Nature communications.

Generation of Leads for γ-Secretase Modulation.

Lynn A. Hyde, A. Palani, Zhaoning Zhu, 2020, Journal of medicinal chemistry.

2′-Modified Guanosine Analogs for the Treatment of HCV

Q. Dang, A. Stamford, Vishal A. Verma, 2016, Nucleosides, Nucleotides & Nucleic Acids.

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.

M. Erion, Fanyu Meng, S. Hollingsworth, 2022, Journal of medicinal chemistry.

Site-Selective Synthesis of Insulin Azides and Bioconjugates.

Xiaohong Zhu, Weijuan Tang, S. Krska, 2019, Bioconjugate chemistry.

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.

Lynn A. Hyde, R. Xu, J. Clader, 2015, Journal of medicinal chemistry.

Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening

Shane W. Krska, Shasha Li, Michael Wleklinski, 2022, ACS Catalysis.

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.

Lynn A. Hyde, W. Greenlee, Wei Zhou, 2013, Bioorganic & medicinal chemistry letters.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Lynn A. Hyde, G. Higgins, J. Clader, 2013, International journal of Alzheimer's disease.

Advances in gamma-secretase modulation.

Dmitri A Pissarnitski, 2007, Current opinion in drug discovery & development.

Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6

Dmitri A Pissarnitski, 2006, Medicinal research reviews.

Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.

W. Greenlee, A. Stamford, R. Xu, 2002, Bioorganic & medicinal chemistry letters.

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.

Lynn A. Hyde, W. Greenlee, A. Palani, 2011, Bioorganic & medicinal chemistry letters.

NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions

M. Bailly, Bradley T. Falk, Songnian Lin, 2020, Chembiochem : a European journal of chemical biology.