Mitchell R Seim

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Christine L Gee, Jennifer L. Martin, C. Gee, 2006, Journal of medicinal chemistry.

Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.

Mitchell R Seim, G. L. Grunewald, Jian Lu, 2006, Journal of medicinal chemistry.

Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.

Mitchell R Seim, Rachel C Regier, G. L. Grunewald, 2007, Bioorganic & medicinal chemistry.

Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Mitchell R Seim, G. L. Grunewald, K. R. Criscione, 2008, Bioorganic & medicinal chemistry.

Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.

D. Bylund, F. A. Romero, Mitchell R Seim, 2005, Bioorganic & medicinal chemistry letters.