Tino W Sanchez

发表

HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding.

Nouri Neamati, Alessia Bacchi, Mauro Carcelli, 2011, Molecular pharmaceutics.

DFS70/LEDGFp75: An Enigmatic Autoantigen at the Interface between Autoimmunity, AIDS, and Cancer

Tino W Sanchez, C. Casiano, Anamika Basu, 2015, Front. Immunol..

Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.

K. W. Jung, N. Neamati, Victor Hadi, 2010, Bioorganic & medicinal chemistry letters.

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.

R. Dayam, N. Neamati, J. Deng, 2007, Bioorganic & medicinal chemistry.

Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement

Noel Southall, A. Simeonov, J. Marugan, 2022, ACS chemical biology.

Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro‐coagulant gene pathway activation

E. Mata-Greenwood, Tino W Sanchez, D. Bellinger, 2020, American journal of reproductive immunology.

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.

N. Neamati, Jian Ding, Yong-tang Zheng, 2012, Journal of medicinal chemistry.

Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.

Erik Serrao, N. Neamati, Yong-tang Zheng, 2014, Bioorganic & medicinal chemistry.

Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.

T. Sanchez, N. Neamati, A. Bacchi, 2011, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.

J. Buolamwini, N. Neamati, R. Schinazi, 2007, Bioorganic & medicinal chemistry.

Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.

T. Sanchez, N. Neamati, J. Gervay-Hague, 2007, Bioorganic & medicinal chemistry.

Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.

R. Dayam, N. Neamati, Li-Fan Zeng, 2008, Bioorganic & medicinal chemistry.

Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines.

N. Neamati, F. Sa̧czewski, M. Gdaniec, 2004, Bioorganic & medicinal chemistry.

Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.

R. Shoemaker, R. Dayam, T. Sanchez, 2004, Journal of medicinal chemistry.

Mining the NCI antiviral compounds for HIV-1 integrase inhibitors.

Y. Pommier, R. Dayam, N. Neamati, 2006, Bioorganic & medicinal chemistry.

Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

N. Neamati, C. Plasencia, T. Oshima, 2009, Cancer biology & therapy.

From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes.

C. Sotriffer, N. Neamati, A. Bacchi, 2008, Journal of medicinal chemistry.

Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors.

T. Sanchez, N. Neamati, A. Bacchi, 2013, Journal of inorganic biochemistry.

Design and Synthesis of Novel Dihydroxyindole-2-Carboxylic Acids as HIV-1 Integrase Inhibitors

Roberto Dallocchio, Alberto Mariani, Fabrizio Carta, 2004, Antiviral chemistry & chemotherapy.

Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.

R. Dayam, N. Neamati, A. Bacchi, 2009, Bioorganic & medicinal chemistry.

Using Serological Proteome Analysis to Identify Serum Anti‐Nucleophosmin 1 Autoantibody as a Potential Biomarker in European‐American and African‐American Patients With Prostate Cancer

L. Dai, Jian-ying Zhang, Jitian Li, 2016, The Prostate.

Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.

N. Neamati, Yang Liu, Daoguang Zhang, 2014, Bioorganic & medicinal chemistry.

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.

N. Neamati, Li-Fan Zeng, Y. Long, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.

N. Neamati, Yang Liu, Yanzhen Yin, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.

J. Buolamwini, N. Neamati, R. Schinazi, 2011, Bioorganic & medicinal chemistry.

Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins*

T. Sanchez, L. Dai, Jian-ying Zhang, 2016, Molecular & Cellular Proteomics.

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.

N. Neamati, Z. Debyser, Stéphanie De Houwer, 2013, Journal of medicinal chemistry.

A real-time cellular thermal shift assay (RT-CETSA) to monitor target engagement

Noel Southall, A. Simeonov, J. Marugan, 2022, bioRxiv.

High-Throughput Cellular Thermal Shift Assay Using Acoustic Transfer of Protein Lysates.

Noel Southall, M. Hall, J. Marugan, 2022, ACS chemical biology.

High-Throughput Detection of Ligand-Protein Binding Using a SplitLuc Cellular Thermal Shift Assay.

A. Simeonov, Tino W Sanchez, M. Henderson, 2021, Methods in molecular biology.

Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes

C. Chen, Tino W Sanchez, C. Casiano, 2017, Oncotarget.

The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding

Michael Mahler, Marvin J. Fritzler, Anamika Basu, 2015, Clinical and Experimental Medicine.

Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target

Tino W Sanchez, C. Casiano, Greisha L. Ortiz-Hernández, 2021, Frontiers in Genetics.

β-Diketo Acid Pharmacophore Hypothesis. 1. Discovery of a Novel Class of HIV-1 Integrase Inhibitors

R. Shoemaker, R. Dayam, T. Sanchez, 2005 .

Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors.

Nouri Neamati, Omoshile Clement, Tino Sanchez, 2005, Journal of medicinal chemistry.

Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients

J. Lynch, Salma Khan, David Turay, 2017, PloS one.

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

N. Neamati, Z. Debyser, F. Christ, 2012, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles.

P. Singh, T. Sanchez, N. Neamati, 2020, ACS medicinal chemistry letters.

Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.

N. Neamati, Yong-tang Zheng, Li-Fan Zeng, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.

T. Sanchez, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.

N. Neamati, Tino W Sanchez, Chao Wang, 2009, Bioorganic & medicinal chemistry.

Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors.

J. Buolamwini, T. Sanchez, N. Neamati, 2013, Bioorganic & medicinal chemistry letters.

Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.

J. Briggs, T. Sanchez, N. Neamati, 2006, Journal of medicinal chemistry.

Design and Synthesis of 3‐Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)

N. Neamati, A. Garofalo, F. Grande, 2012, ChemMedChem.

Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.

R. Dayam, T. Sanchez, N. Neamati, 2005, Journal of medicinal chemistry.

Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.

J. Briggs, Keun Woo Lee, T. Sanchez, 2005, Journal of medicinal chemistry.

Discovery and Structure–Activity Relationship Studies of a Unique Class of HIV‐1 Integrase Inhibitors

R. Dayam, N. Neamati, Tino W Sanchez, 2006, ChemMedChem.

Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.

K. W. Jung, N. Neamati, Victor Hadi, 2010, Bioorganic & medicinal chemistry letters.