Kirk J. Nelson

发表

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, 2013, PloS one.

In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa

M. Castanheira, M. Dudley, Dongxu Sun, 2021, Antimicrobial Agents and Chemotherapy.

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

M. Totrov, M. Dudley, Dongxu Sun, 2020, Antimicrobial Agents and Chemotherapy.

Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

M. Dudley, Dongxu Sun, Kirk J. Nelson, 2020, Antimicrobial Agents and Chemotherapy.

Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity

A. Kasarskis, G. Weinstock, R. Sebra, 2017, Antimicrobial Agents and Chemotherapy.

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

D. McRee, J. Nix, R. Swanson, 2006, Bioorganic & medicinal chemistry letters.

Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae

M. Dudley, Dongxu Sun, Kirk J. Nelson, 2017, Antimicrobial Agents and Chemotherapy.

Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae

D. C. Griffith, M. Dudley, Dongxu Sun, 2017, Antimicrobial Agents and Chemotherapy.

Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay

M. Cunningham, Bryan P. Kwan, K. Shaw, 2013, Journal of biomolecular screening.

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.

Mark Stidham, Mark Hilgers, John Finn, 2011, Bioorganic & medicinal chemistry letters.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Toan B. Nguyen, Sergio E. Wong, F. Lightstone, 2013, Bioorganic & medicinal chemistry letters.

In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms

M. Dudley, Dongxu Sun, Kirk J. Nelson, 2020, Antimicrobial Agents and Chemotherapy.

Discovery of Cyclic Boronic Acid QPX7728, an Ultra-broad-spectrum Inhibitor of Serine and Metallo Beta-lactamases.

M. Totrov, Yu Chen, K. R. Reddy, 2020, Journal of medicinal chemistry.

In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

M. Totrov, M. Dudley, Dongxu Sun, 2020, Antimicrobial Agents and Chemotherapy.

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.

M. Hilgers, M. Cunningham, Bryan P. Kwan, 2014, Journal of medicinal chemistry.

Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action

J. Pogliano, Dongxu Sun, Hannah Tsunemoto, 2022, Antimicrobial agents and chemotherapy.

Macromolecular Synthesis Assay Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a

L. Cunningham, Bryan P. Kwan, K. Shaw, 2013 .

Assessment of MIC Increases with Meropenem-Vaborbactam and Ceftazidime-Avibactam in TANGO II (a Phase 3 Study of the Treatment of CRE Infections)

K. Kaye, M. Yin, M. Dudley, 2017 .

In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales

M. Castanheira, M. Totrov, Kirk J. Nelson, 2023, Antimicrobial agents and chemotherapy.