A. Pehrson

发表

Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems.

C. Sánchez, D. Roberts, Andrew Wolfarth, 2018, Progress in brain research.

Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission

C. Sánchez, A. Pehrson, Theepica Jeyarajah, 2015, CNS Spectrums.

Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

C. Sánchez, J. Tamm, A. Pehrson, 2015, Pharmacology Biochemistry and Behavior.

The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine’s effects by the &agr;2 adrenoceptor antagonist yohimbine

A. Prus, J. Porter, A. Pehrson, 2015, Behavioural pharmacology.

Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine.

C. Sánchez, S. Leiser, A. Pehrson, 2015, ACS chemical neuroscience.

Acute effects of vortioxetine and duloxetine on resting-state functional connectivity in the awake rat

C. Bundgaard, C. Sánchez, A. Mørk, 2018, Neuropharmacology.

Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism

C. Sánchez, D. Budac, A. Pehrson, 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Task- and Treatment Length–Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats

C. Sánchez, A. Mørk, D. Budac, 2016, The Journal of Pharmacology and Experimental Therapeutics.

The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats

A. Prus, J. Porter, S. Philibin, 2009, Psychopharmacology.

Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats

D. Jezova, C. Sánchez, I. Bermúdez, 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors

L. Wise, B. Bang-Andersen, A. Prus, 2016, Brain Research.

Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task

A. Prus, J. Porter, S. Philibin, 2005, Behavioural pharmacology.

Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice

A. Prus, J. Porter, S. Philibin, 2005, Psychopharmacology.

Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two‐choice drug discrimination task

L. Wise, A. Prus, J. Porter, 2005 .

Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine.

C. Sánchez, S. Leiser, A. Pehrson, 2015, European journal of pharmacology.

A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

C. Sánchez, D. Budac, A. Pehrson, 2012, Behavioural Brain Research.

The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: Analysis of brain area epibatidine binding and cotinine levels

S. Robinson, Daniel Gross, R. Vann, 2008, Pharmacology Biochemistry and Behavior.

Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission

C. Sánchez, A. Pehrson, K. Tølbøl, 2018, Front. Pharmacol..

Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats

Robert E. Vann, S. Robinson, A. Prus, 2008, Pharmacology Biochemistry and Behavior.

Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

C. Sánchez, C. Olsen, S. Leiser, 2015, CNS Spectrums.

Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

B. Moghaddam, A. Pehrson, 2010, Psychopharmacology.

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

J. Nielsen, Charles R. Yang, C. Sánchez, 2017, Brain Research.

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

C. Sánchez, A. Pehrson, 2015, Drug design, development and therapy.

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

C. Sánchez, A. Pehrson, 2013, CNS Spectrums.

Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Tine Bryan Stensbøl, C. Bundgaard, R. Mcquade, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Case Study 2: The Discovery and Development of the Multimodal Acting Antidepressant Vortioxetine

C. Bundgaard, C. Sánchez, B. Bang-Andersen, 2015 .

Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

C. Bundgaard, G. Wegener, C. Sánchez, 2012, Journal of Pharmacology and Experimental Therapeutics.

In vivo and in vitro effects of vortioxetine on molecules associated with neuroplasticity

C. Sánchez, P. Kugathasan, J. Tamm, 2017, Journal of psychopharmacology.

Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle

A. Prus, J. Porter, S. Philibin, 2006, Behavioural pharmacology.

Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram

A. West, C. Sánchez, T. Geisbush, 2017, Front. Pharmacol..

Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

C. Sánchez, D. Budac, A. Pehrson, 2014, European Neuropsychopharmacology.

Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

C. Sánchez, A. Pehrson, K. D. Jardin, 2014, European Neuropsychopharmacology.

Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

C. Sánchez, D. David, J. Guilloux, 2018, Front. Pharmacol..

The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse

Benjamin D. Sachs, M. Caron, P. Plenge, 2014, Psychopharmacology.

P.2.e.003 The impact of antipsychotic drugs in depression: a role for adult neurogenesis?

R. Oosting, C. Sánchez, B. Olivier, 2014 .

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

C. Sánchez, A. Pehrson, Yan Li, 2015, Front. Neurosci..

A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant

D. Overstreet, C. Bundgaard, C. Sánchez, 2015, Pharmacology Biochemistry and Behavior.

Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine – a quantitative EEG study in rats

C. Sánchez, S. Leiser, A. Pehrson, 2014, British journal of pharmacology.

The role of serotonin neurotransmission in rapid antidepressant actions

A. Pehrson, A. Khawaja, R. McNair, 2022, Psychopharmacology.

Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory

C. Sánchez, C. Bétry, N. Haddjeri, 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism.

C. Sánchez, C. Bétry, N. Haddjeri, 2013, The international journal of neuropsychopharmacology.

Vortioxetine reduces marble burying but only transiently enhances social interaction preference in adult male BTBR T+Itpr3tf/J mice.

C. Sánchez, G. Gould, A. Pehrson, 2019, ACS chemical neuroscience.

Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

C. Sánchez, T. Hillhouse, J. Porter, 2018, Front. Pharmacol..

Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—A rat microdialysis and electrophysiology study

C. Sánchez, C. Bétry, N. Haddjeri, 2013, European Neuropsychopharmacology.

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

D. Morilak, C. Sánchez, A. Pehrson, 2014, The international journal of neuropsychopharmacology.

P.2.h.002 Effects of the multimodal antidepressant Lu AA21004 on rat synaptic and cellular hippocampal plasticity and memory recognition

C. Sánchez, C. Bétry, N. Haddjeri, 2012, European Neuropsychopharmacology.

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

C. Sánchez, S. Leiser, A. Pehrson, 2015, Journal of psychopharmacology.

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

R. Hen, C. Repérant, C. Sánchez, 2013, Neuropharmacology.

P.1.g.052 Serotonin transporter-independent actions of the antidepressant vortioxetine as revealed in studies of the SERT Met172 mouse

R. Blakely, C. Sánchez, A. Pehrson, 2015, European Neuropsychopharmacology.

Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

R. Wernersson, C. Sánchez, B. Elfving, 2017, BMC Neuroscience.

A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation

R. Oosting, C. Sánchez, B. Olivier, 2017, Neuropharmacology.

Disinhibition of Prefrontal Cortex Neurons in Schizophrenia

B. Moghaddam, A. Pehrson, A. L. Pehrson, 2010 .

The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention

C. Bondi, B. Moghaddam, Nelson K. Totah, 2012, Psychopharmacology.

Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

R. Wernersson, C. Sánchez, B. Elfving, 2017, BMC Neuroscience.

Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

C. Sánchez, J. Tamm, A. Pehrson, 2017, European Neuropsychopharmacology.

The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention

C. Bondi, B. Moghaddam, Nelson K. Totah, 2012, Psychopharmacology.

Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

C. Bundgaard, R. Mcquade, H. Yamashita, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats

S. Robinson, A. Prus, R. Vann, 2008, Pharmacology Biochemistry and Behavior.

Vortioxetine Improves Mood and Cognitive Function in Animal Models of Psychiatric Disease: Relevance of 5-HT3 Receptor-Mediated Regulation of GABA and Glutamate Neurotransmission

C. Sánchez, A. Pehrson, Yan Li, 2021, Biological Psychiatry.

Serotonin Transporter‐Independent Actions of the Antidepressant Vortioxetine as Revealed Using the SERT M172 Mouse

R. Blakely, C. Sánchez, A. Pehrson, 2015, ACS chemical neuroscience.

P.1.g.014 Vortioxetine, a novel multimodal antidepressant, modulates GABA and glutamate neurotransmission via serotonergic mechanisms

C. Sánchez, N. Haddjeri, A. Pehrson, 2013, European Neuropsychopharmacology.