A. Sebastião

发表

Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus.

D. Rombo, R. Dias, A. Félix-Oliveira, 2014, Journal of neurophysiology.

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

J. Changeux, B. Lambolez, B. Gutkin, 2013, Molecular Psychiatry.

Mechanisms of Regulation of Olfactory Transduction and Adaptation in the Olfactory Cilium

G. Antunes, F. M. Simões de Souza, A. Sebastião, 2014, PloS one.

Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT‐1

J. Ribeiro, A. Sebastião, S. Cristóvão-Ferreira, 2009, Journal of neurochemistry.

Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats

R. Cunha, A. de Mendonça, J. Ribeiro, 2000, British journal of pharmacology.

Neuroprotection during hypoxic insults: Role of adenosine

A. de Mendonça, J. Ribeiro, A. Sebastião, 2001 .

The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8‐substituted xanthines

T. Stone, J. Ribeiro, A. Sebastião, 1990, British journal of pharmacology.

Modification of A‐i and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat

R. Cunha, J. Ribeiro, A. Sebastião, 1995, Neuroreport.

Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides

R. Cunha, P. Correia‐de‐Sá, J. Ribeiro, 1996, British journal of pharmacology.

Adenosine by activating A1 receptors prevents GABAA-mediated actions during hypoxia in the rat hippocampus

S. Latini, A. Mendonça, J. Ribeiro, 1996, Brain Research.

Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects

Ana I. Domingos, A. Koulman, Y. Sanz, 2020, Cell metabolism.

Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog.

R. Cunha, A. Sebastião, 1991, European journal of pharmacology.

Multicompartment Microreactors Prevent Excitotoxic Dysfunctions In Rat Primary Cortical Neurons

B. Städler, J. Coelho, Luísa V. Lopes, 2020, Advanced biosystems.

On the Assembly of Microreactors with Parallel Enzymatic Pathways

B. Städler, A. Sebastião, S. Vaz, 2018, Advanced biosystems.

Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons

D. Rombo, R. Dias, J. Ribeiro, 2018, British journal of pharmacology.

Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors

B. Fredholm, R. Cunha, A. Sebastião, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines

A. Costa, J. Tomás, C. Santos, 2021, Neuroscience.

Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation

J. Tomás, C. Santos, A. Sebastião, 2019, Journal of neurochemistry.

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

Rui F. M. Silva, M. Sousa, D. Brites, 2016, Brain Structure and Function.

Modulation of cGMP accumulation by adenosine A1 receptors at the hippocampus: influence of cGMP levels and gender.

A. Sebastião, J. F. Cascalheira, A. Serpa, 2014, European journal of pharmacology.

Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity

D. Pereira, J. Ribeiro, A. Sebastião, 2013, Purinergic Signalling.

Activation of Adenosine A2A Receptors Induces TrkB Translocation and Increases BDNF-Mediated Phospho-TrkB Localization in Lipid Rafts: Implications for Neuromodulation

M. Chao, D. Pereira, J. Ribeiro, 2010, The Journal of Neuroscience.

Cellular / Molecular Activation of Adenosine A 2 A Receptors Induces TrkB Translocation and Increases BDNF-Mediated Phospho-TrkB Localization in Lipid Rafts : Implications for Neuromodulation

M. Chao, D. Pereira, J. Ribeiro, 2010 .

A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+-evoked [3H]-GABA release from rat hippocampal nerve terminals

J. Ribeiro, A. Sebastião, D. Cunha-Reis, 2008, Neuroscience Letters.

Predominance of Adenosine Excitatory over Inhibitory Effects on Transmission at the Neuromuscular Junction of Infant Rats

A. M. Correia, Paula A Pousinha, J. Ribeiro, 2010, Journal of Pharmacology and Experimental Therapeutics.

Research Overview Adenosine Receptor Interactions in the Hippocampus

R. Cunha, A. Mendonça, P. Correia‐de‐Sá, 2001 .

Adenosine receptor interactions in the hippocampus

R. Cunha, A. de Mendonça, P. Correia‐de‐Sá, 2001 .

Purinergic Modulation of the Evoked Release of [3H]Acetylcholine from the Hippocampus and Cerebral Cortex of the Rat: Role of the Ectonucleotidases

R. Cunha, J. Ribeiro, A. Sebastião, 1994, The European journal of neuroscience.

Microglia Depletion from Primary Glial Cultures Enables to Accurately Address the Immune Response of Astrocytes

C. Valente, A. Sebastião, Mariana Van Zeller, 2022, Biomolecules.

Neuronal ENT1 takes up synaptic adenosine even under hypoxia/ischemia

A. Sebastião, 2011, Journal of neurochemistry.

On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction.

J. Ribeiro, A. Sebastião, 1987, The Journal of physiology.

Adenine nucleotides as inhibitors of synaptic transmission: role of localised ectonucleotidases.

R. Cunha, J. Ribeiro, A. Sebastião, 1999, Progress in brain research.

Chapter 23 Purinergic regulation of acetylcholine release

R. Cunha, P. Correia‐de‐Sá, J. Ribeiro, 1996 .

1,3,8‐ and 1,3,7‐substituted xanthines: relative potency as adenosine receptor antagonists at the frog neuromuscular junction

J. Ribeiro, A. Sebastião, 1989, British journal of pharmacology.

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

E. Castrén, H. Tanila, S. Davis, 2012, Neurobiology of Aging.

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

J. Malva, L. Bernardino, R. A. de Melo Reis, 2014, Front. Cell. Neurosci..

Biological activities of N6,C8-disubstituted adenosine derivatives as partial agonists at rat brain adenosine A1 receptors.

A. IJzerman, J. Ribeiro, U. Schwabe, 1997, European journal of pharmacology.

Changes in adenosine and neurotrophic signaling in the SOD1G93A mouse model of amyotrophic lateral sclerosis: modulation by chronic caffeine intake

C. Valente, J. Ribeiro, A. Sebastião, 2022, bioRxiv.

Hippocampal synaptic dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis: Reversal by adenosine A2AR blockade

C. Müller, Y. Baqi, D. Rombo, 2020, Neuropharmacology.

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

C. Limatola, B. Frenguelli, L. Maggi, 2014, Cerebral cortex.

Adenosine A2A Receptors Activation Facilitates Neuromuscular Transmission in the Pre-Symptomatic Phase of the SOD1(G93A) ALS Mice, but Not in the Symptomatic Phase

A. M. Correia, J. Ribeiro, Paula A. Pousinha, 2014, PloS one.

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

A. M. Correia, J. Ribeiro, Paula A. Pousinha, 2013, PloS one.

From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications.

J. Ribeiro, A. Sebastião, Filipa F Ribeiro, 2012, CNS & neurological disorders drug targets.

Tonic activation of A2A adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene‐related peptide in the rat hippocampus

J. Ribeiro, M. P. Macedo, A. Sebastião, 2000, British journal of pharmacology.

Effect of 5′‐(N‐Ethylcarboxamido)adenosine on Adenosine Transport in Cultured Chromaffin Cells

J. Ribeiro, A. Sebastião, E. Delicado, 1990, Journal of neurochemistry.

Cannabinoid CB(1) and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission.

J. Ribeiro, A. Sebastião, A. Serpa, 2009, European journal of pharmacology.

Adenosine A1 receptor activation inhibits basal accumulation of inositol phosphates in rat hippocampus.

A. Sebastião, J. F. Cascalheira, 1998, Pharmacology & toxicology.

Is inhibition of neurotransmitter release mediated by A3 receptors? Subtypes of adenosine receptors

J. Ribeiro, A. Sebastião, 1988 .

On the type of receptor involved in the inhibitory action of adenosine at the neuromuscular junction

J. Ribeiro, A. Sebastião, 1985, British journal of pharmacology.

Enhancement of tetrodotoxin‐induced axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic AMP and methylxanthines in the frog sciatic nerve

J. Ribeiro, A. Sebastião, 1984, British journal of pharmacology.

Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection

A. IJzerman, H. Boddeke, A. Pinto-Duarte, 2008, Neuropsychopharmacology.

Participation of adenosine receptors in neuroprotection.

A. de Mendonça, J. Ribeiro, A. Sebastião, 2003, Drug news & perspectives.

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

R. Cunha, A. de Mendonça, J. Coelho, 2002, Pharmacology & toxicology.

NLRP3 inflammasome as a potential target to reduce epileptic-like activity: PS188.

C. Valente, D. Rombo, A. Sebastião, 2017, Porto biomedical journal.

Postsynaptic Action of Brain-Derived Neurotrophic Factor Attenuates α7 Nicotinic Acetylcholine Receptor-Mediated Responses in Hippocampal Interneurons

A. Pinto-Duarte, J. Ribeiro, A. Sebastião, 2008, The Journal of Neuroscience.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

A. M. Correia, D. Brites, A. Fernandes, 2017, Molecular Neurobiology.

Further evidence for adenosine A3 receptors.

J. Ribeiro, A. Sebastião, 1994, Trends in pharmacological sciences.

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain.

E. Castrén, D. Blum, V. Buée-Scherrer, 2015, Cerebral cortex.

Pertussis Toxin-Sensitive G Proteins Mediate the Inhibition of Basal Phosphoinositide Metabolism Caused by Adenosine A1 Receptors in Rat Hippocampal Slices

J. Ribeiro, A. Sebastião, J. F. Cascalheira, 2002, Neurochemical Research.

Ascorbate/Fe3+-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes

J. Ribeiro, A. Sebastião, M. Constantino, 1995, Neurochemistry International.

On the high affinity binding site for [3H]‐1,3‐dipropyl‐8‐cyclopentylxanthine in frog brain membranes

J. Ribeiro, A. Sebastião, J. C. Oliveira, 1993, British journal of pharmacology.

Solubilized Rat Brain Adenosine Receptors Have Two High‐Affinity Binding Sites for l, 3‐Dipropyl‐8‐Cyclopentylxanthine

J. Ribeiro, A. Sebastião, J. C. Oliveira, 1991, Journal of neurochemistry.

Neuromuscular transmission modulation by adenosine upon aging

A. M. Correia, J. Ribeiro, Paula A. Pousinha, 2012, Neurobiology of Aging.

Platinum nanoparticle-based microreactors protect against the behavioral and neurobiological consequences of chronic stress exposure

Roberto Oliveira, A. Sebastião, S. Vaz, 2022, Brain Research Bulletin.

Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus

C. Lluis, R. Franco, S. Ferré, 2011, The Journal of Neuroscience.

Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals

J. Ribeiro, A. Sebastião, S. Cristóvão-Ferreira, 2008, Brain Research.

Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms

J. Ribeiro, N. Canas, A. Sebastião, 2004, Brain Research.

Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior

A. Sebastião, P. Serrão, S. Vaz, 2021, Neuropharmacology.

In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

T. Carvalho, J. Loureiro, M. C. Pereira, 2020, International journal of nanomedicine.

GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function

Rita I Aroeira, C. Valente, A. Sebastião, 2014, Brain Structure and Function.

Adenosine, Cyclic AMP and Nerve Conduction

J. Ribeiro, A. Sebastião, 1987 .

Inhibition of NMDA receptor‐mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation

A. de Mendonça, A. Sebastião, A. Ribeiro, 1995, Neuroreport.

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

R. Dias, J. Ribeiro, M. Colino-Oliveira, 2013, Neuropharmacology.

Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes

C. Valente, A. Sebastião, S. Vaz, 2018, Front. Mol. Neurosci..

Hippocampal CA1 Pyramidal Cells Requirements for LTP Induction by Pairing in

David S. Park, P. Calabresi, J. Lisman, 2015 .

Adenosine A2A Receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD)

A. Sebastião, André Jerónimo-Santos, Tiago M. Rodrigues, 2014, Neuropharmacology.

Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor

J. Ribeiro, A. Sebastião, 1986, Progress in Neurobiology.

Caffeine and adenosine.

Ana M Sebastião, J. Ribeiro, Joaquim A Ribeiro, 2010, Journal of Alzheimer's disease : JAD.

Preferential Release of ATP and Its Extracellular Catabolism as a Source of Adenosine upon High‐ but Not Low‐Frequency Stimulation of Rat Hippocampal Slices

E. Vizi, R. Cunha, J. Ribeiro, 1996, Journal of neurochemistry.

Adenosine A2 receptor-mediated excitatory actions on the nervous system

J. Ribeiro, A. M. Sebastião, J. A. Ribeiro, 1996, Progress in Neurobiology.

Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction

J. Ribeiro, A. Sebastião, 1990, British journal of pharmacology.

Activation of Synaptic NMDA Receptors by Action Potential-Dependent Release of Transmitter during Hypoxia Impairs Recovery of Synaptic Transmission on Reoxygenation

J. Ribeiro, A. Sebastião, T. Moreira, 2001, The Journal of Neuroscience.

P2Y1 receptor inhibits GABA transport through a calcium signalling‐dependent mechanism in rat cortical astrocytes

Pedro F. Jacob, J. Ribeiro, A. Sebastião, 2014, Glia.

Adenosine and related drugs in brain diseases: present and future in clinical trials.

Luísa V. Lopes, J. Ribeiro, A. Sebastião, 2011, Current topics in medicinal chemistry.

On the adenosine receptor and adenosine inactivation at the rat diaphragm neuromuscular junction

J. Ribeiro, A. Sebastião, 1988, British journal of pharmacology.

Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat

P. Correia‐de‐Sá, J. Ribeiro, A. Sebastião, 1991, British journal of pharmacology.

Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation

C. Müller, Y. Baqi, J. Coelho, 2017, Neuropharmacology.

Adenosine A2A Receptor Modulation of Hippocampal CA3-CA1 Synapse Plasticity During Associative Learning in Behaving Mice

J. Delgado-García, A. Gruart, J. Ribeiro, 2009, Neuropsychopharmacology.

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

V. Crunelli, A. Sebastião, S. Vaz, 2020, Frontiers in Cellular Neuroscience.

Tuning and Fine-Tuning of Synapses with Adenosine

J. Ribeiro, A. Sebastião, 2009, Current neuropharmacology.

Fine-tuning neuromodulation by adenosine.

J. Ribeiro, A. Sebastião, 2000, Trends in pharmacological sciences.

Adenine nucleotide analogues, including gamma-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle.

A. Sebastião, J. F. Cascalheira, 1992, European journal of pharmacology.

Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog

R. Cunha, A. Sebastião, 1993, Pflügers Archiv.

Challenges of BDNF-based therapies: from common to rare diseases.

Rita F. Belo, A. Sebastião, C. Miranda-Lourenço, 2020, Pharmacological research.

Purine nucleosides in neuroregeneration and neuroprotection

J. Ribeiro, A. Sebastião, C. Miranda-Lourenço, 2016, Neuropharmacology.

Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson’s Disease

J. Ribeiro, A. Sebastião, M. J. Diógenes, 2015 .

Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection

J. Ribeiro, A. Sebastião, 2009, British journal of pharmacology.

GDNF control of the glutamatergic cortico‐striatal pathway requires tonic activation of adenosine A2A receptors

Catarina Gomes, R. Cunha, S. Ferré, 2009, Journal of neurochemistry.

Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine

J. Ribeiro, B. Fontinha, A. Sebastião, 2008, Neuropharmacology.

Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner

Catarina Gomes, J. Ribeiro, A. Sebastião, 2006, Brain Research.

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.

R. Cunha, A. de Mendonça, N. Rebola, 2003, Journal of neurophysiology.

Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses

J. Henley, D. Rombo, R. Dias, 2018, Cerebral cortex.

Neuroinflammatory modulators of oligodendrogenesis

A. Sebastião, S. Xapelli, Filipa F Ribeiro, 2015 .

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors

D. Rombo, R. Dias, J. Ribeiro, 2016, Purinergic Signalling.

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

R. D'Hooge, C. Rodrigues, J. Amaral, 2013, Neurobiology of Aging.

Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors

J. Ribeiro, A. Sebastião, N. Rei, 2018, Front. Pharmacol..

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.

J. Relvas, C. Brakebusch, A. Ambrósio, 2019, Cell reports.

Genetic ablation of RhoA in adult microglia causes synapse and neuronal loss

J. Relvas, C. Brakebusch, A. Ambrósio, 2017, bioRxiv.

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

C. Valente, D. Rombo, A. Sebastião, 2018, Journal of neuroinflammation.

Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis

Filipa Ferreira, A. Sebastião, S. Vaz, 2017, Front. Pharmacol..

Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease

T. Outeiro, A. Sebastião, André Jerónimo-Santos, 2014, Drugs & Aging.

VPAC1 and VPAC2 receptor activation on GABA release from hippocampal nerve terminals involve several different signalling pathways

J. Ribeiro, A. Sebastião, R. F. D. de Almeida, 2017, British journal of pharmacology.

VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors

J. Ribeiro, A. Sebastião, D. Cunha-Reis, 2005, Brain Research.

Caffeine and Adenosine Receptor Modulation of Cannabinoid Influence Upon Cognitive Function

J. Ribeiro, A. Sebastião, V. Sousa, 2013 .

Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory

J. Pratt, R. Brett, J. Ribeiro, 2011, Neuropsychopharmacology.

Adult neural stem cells as promising targets in psychiatric disorders.

A. Sebastião, Sara L Paulo, Rui S Rodrigues, 2020, Stem cells and development.

Anxiety Assessment in Pre-clinical Tests and in Clinical Trials: A Critical Review.

D. Telles-Correia, A. Sebastião, L. Castanheira, 2018, Current topics in medicinal chemistry.

N6‐Cyclohexyladenosine Inhibits Veratridine‐Stimulated Na Uptake by Rat Brain Synaptosomes

J. Ribeiro, A. Sebastião, A. P. Simões, 1988, Journal of neurochemistry.

Purinergic regulation of acetylcholine release.

R. Cunha, P. Correia‐de‐Sá, J. Ribeiro, 1996, Progress in brain research.

Control of glutamate release by complexes of adenosine and cannabinoid receptors

L. Pardo, F. Ciruela, Samira G. Ferreira, 2020, BMC Biology.

MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins

Joana M. Xavier, C. Rodrigues, S. Solá, 2014, Molecular Neurobiology.

Role of Adenosine Receptors in Epileptic Seizures

D. Rombo, J. Ribeiro, A. Sebastião, 2018 .

Pharmacodynamics and Pharmacokinetics of Stroke Therapy

A. Sebastião, M. Rato, M. J. Diógenes, 2021, Precision Medicine in Stroke.

Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice

N. Dawson, Frederico Simões do Couto, A. Sebastião, 2021, Journal of psychopharmacology.

Adenosine: does it have a neuroprotective role after all?

Alexandre de Mendonça, A. Mendonça, J. Ribeiro, 2000, Brain Research Reviews.

Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis

Filipa Ferreira, A. Sebastião, Rui S Rodrigues, 2018, Front. Cell. Neurosci..

Role of Adenosine in Epilepsy and Seizures.

Â. R. Tomé, R. Cunha, D. Rombo, 2020, Journal of caffeine and adenosine research.

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

Rui F. M. Silva, N. Rooijen, D. Brites, 2012, Neuropharmacology.

Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome

C. Limatola, E. Aronica, E. Palma, 2020, Neuroscience.

From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?

A. Sebastião, C. Miranda-Lourenço, Francisco M. Mouro, 2019, Front. Neurosci..

Astrocytes in Amyotrophic Lateral Sclerosis

D. Brites, A. Sebastião, S. Vaz, 2021, Amyotrophic Lateral Sclerosis.

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity

A. Sebastião, S. Vaz, Carolina Campos Pina, 2019, Front. Cell. Neurosci..

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

L. Lannfelt, M. Ingelsson, T. Outeiro, 2012, The Journal of Neuroscience.

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

A. Köfalvi, C. Müller, Y. Baqi, 2019, Neuropharmacology.

Adenosine receptors in the nervous system: pathophysiological implications

A. Mendonça, J. Ribeiro, A. M. Sebastião, 2002, Progress in Neurobiology.

Maternal separation impairs long term-potentiation in CA1-CA3 synapses and hippocampal-dependent memory in old rats

Luísa V. Lopes, J. Ribeiro, A. Sebastião, 2014, Neurobiology of Aging.

Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF

Luísa V. Lopes, J. Ribeiro, B. Fontinha, 2011, Neuropsychopharmacology.

Enhancement of transmission at the frog neuromuscular junction by adenosine deaminase: Evidence for an inhibitory role of endogenous adenosine on neuromuscular transmission

J. Ribeiro, A. Sebastião, 1985, Neuroscience Letters.

Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine

C. Valente, J. Ribeiro, A. Sebastião, 2022, PloS one.

Hypoxia–Ischemia Alters Nucleotide and Nucleoside Catabolism and Na+,K+-ATPase Activity in the Cerebral Cortex of Newborn Rats

V. Morsch, M. Bagatini, D. Zanini, 2013, Neurochemical Research.

Adenosine: setting the stage for plasticity

J. Henley, D. Rombo, R. Dias, 2013, Trends in Neurosciences.

Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder.

J. Ribeiro, A. Sebastião, S. Vaz, 2020, Pharmacological research.

Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity

N. Dawson, J. Ribeiro, A. Sebastião, 2018, Journal of neurochemistry.

Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures

J. Malva, T. Santos, J. Bragança, 2013, PloS one.

The Combined Inhibitory Effect of the Adenosine A1 and Cannabinoid CB1 Receptors on cAMP Accumulation in the Hippocampus Is Additive and Independent of A1 Receptor Desensitization

J. Ribeiro, A. Sebastião, S. Correia, 2015, BioMed research international.

Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors

J. Ribeiro, Paula A. Pousinha, A. Sebastião, 2006, Neuroscience Letters.

Activation of Adenosine a 2a Receptor Facilitates Brain- Derived Neurotrophic Factor Modulation of Synaptic Transmission in Hippocampal Slices

J. Ribeiro, A. Sebastião, C. Fernandes, 2003 .

Enhanced LTP in aged rats: Detrimental or compensatory?

A. Mendonça, R. Vale, D. Rombo, 2017, Neuropharmacology.

Adenosine receptors and the central nervous system.

Ana M Sebastião, J. Ribeiro, Joaquim A Ribeiro, 2009, Handbook of experimental pharmacology.

Dual Influence of Endocannabinoids on Long-Term Potentiation of Synaptic Transmission

M. Carlström, J. Ribeiro, A. Sebastião, 2017, Front. Pharmacol..

Purinoceptors and synaptic plasticity

R. Cunha, A. de Mendonça, P. Correia‐de‐Sá, 1996 .

The Role of cGMP on Adenosine A1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus

A. Sebastião, J. F. Cascalheira, A. Serpa, 2016, Front. Pharmacol..

Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation

J. Ribeiro, A. Sebastião, 2015, Brain Research.

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

R. Ramalho, Luísa V. Lopes, A. Sebastião, 2018, Front. Pharmacol..

Adenosine and Its Receptors as Potential Drug Targets in Amyotrophic Lateral Sclerosis

Y. Chern, J. Ribeiro, A. Sebastião, 2019 .

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

E. Castrén, A. Sebastião, P. Casarotto, 2019, Front. Mol. Neurosci..

Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes

A. Sebastião, S. Vaz, S. Parreira, 2015, Purinergic Signalling.

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity

Y. Huo, A. Jones, D. Boison, 2016, The Journal of Neuroscience.

Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection

A. IJzerman, H. Boddeke, A. Pinto-Duarte, 2008, Neuropsychopharmacology.

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures.

C. Valente, A. Sebastião, Francisco J. Meda, 2021, Journal of visualized experiments : JoVE.

Antagonism of tetrodotoxin‐ and procaine‐induced axonal blockade by adenine nucleotides in the frog sciatic nerve

J. Ribeiro, A. Sebastião, 1984, British journal of pharmacology.

Ischemia-induced synaptic plasticity drives sustained expression of calcium-permeable AMPA receptors in the hippocampus

D. Rombo, R. Dias, J. Ribeiro, 2013, Neuropharmacology.

Modulation and metamodulation of synapses by adenosine

J. Ribeiro, A. Sebastião, 2010, Acta physiologica.

Synaptic mechanisms of adenosine A2A receptor‐mediated hyperexcitability in the hippocampus

K. Lamsa, L. Minichiello, D. Rombo, 2015, Hippocampus.

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus

J. Ribeiro, A. Sebastião, 1992, Neuroscience Letters.

Hippocampal GABAergic transmission: a new target for adenosine control of excitability

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Excitatory and Inhibitory Effects of A1 and A2A Adenosine Receptor Activation on the Electrically Evoked [3H]Acetylcholine Release from Different Areas of the Rat Hippocampus

E. Vizi, R. Cunha, E. Vizi, 1994, Journal of neurochemistry.

Adenosine A 3 Receptor Signaling in the Central Nervous System

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Modeling the functional network of primary intercellular Ca2+ wave propagation in astrocytes and its application to study drug effects.

Pedro G Lind, Frank Raischel, F. Raischel, 2013, Journal of theoretical biology.

BDNF Effect upon Apoptosis Induced by Amyloid-Beta Peptide: Changes in TRKB Receptors Expression

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Downstream Pathways of Adenosine

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On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor present in rat motor nerve terminals.

J. Ribeiro, A. Sebastião, D. G. Oliveira, 1997, Pharmacology & toxicology.

Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons

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The giant miniature endplate potentials frequency is increased in aged rats

A. M. Correia, J. Ribeiro, Paula A. Pousinha, 2015, Neuroscience Letters.

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP

C. Müller, Luísa V. Lopes, A. Sebastião, 2014, Neuropharmacology.

An adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of the rat retina.

A. de Mendonça, J. Ribeiro, A. Sebastião, 1999, Experimental Eye Research.

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

Rui F. M. Silva, M. Sousa, D. Brites, 2016, Brain Structure and Function.

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

C. Lluis, R. Franco, V. Casadó, 2013, Purinergic Signalling.

Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

J. Ribeiro, A. Sebastião, 2023, Neuropharmacology.

Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission

J. Ribeiro, A. Sebastião, Filipe Nascimento, 2015, Purinergic Signalling.

VIP enhances both pre‐ and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells

P. Illés, K. Wirkner, J. Ribeiro, 2004, British journal of pharmacology.

Influence of age on BDNF modulation of hippocampal synaptic transmission: Interplay with adenosine A2A receptors

A. Pinto-Duarte, J. Ribeiro, A. Sebastião, 2007, Hippocampus.

Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus.

J. Ribeiro, Isabel Fragata, A. Sebastião, 2006, European journal of pharmacology.

Ecto‐5′‐Nucleotidase Is Associated with Cholinergic Nerve Terminals in the Hippocampus but Not in the Cerebral Cortex of the Rat

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Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A(2A) receptors and the role of lipid rafts.

J. Ribeiro, A. Sebastião, S. Vaz, 2011, Biochimica et biophysica acta.

Inhibition by ATP of Hippocampal Synaptic Transmission Requires Localized Extracellular Catabolism by Ecto-Nucleotidases into Adenosine and Channeling to Adenosine A1 Receptors

R. Cunha, J. Ribeiro, A. Sebastião, 1998, The Journal of Neuroscience.

Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

J. Ribeiro, A. Sebastião, 2023, Neuropharmacology.

Platinum Nanoparticle-Based Microreactors as Support for Neuroblastoma Cells.

B. Städler, Essi M Taipaleenmäki, P. Schattling, 2017, ACS applied materials & interfaces.

Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor (BDNF) signalling in the prefrontal cortex (PFC), but not in the hippocampus, and disturbs PFC-dependent cognition in mice Running head: BDNF function is lost in PFC of PCP-treated mice

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Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus

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Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin‐releasing factor (CRF) in glutamate injured cortical neurons

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Enhancement of AMPA currents and GluR1 membrane expression through PKA‐coupled adenosine A2A receptors

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Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus

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Influence of Adenosine on Synaptic Excitability

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Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus

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Neuroinflammation after neonatal hypoxia–ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult

M. Schetinger, D. Zanini, M. B. Moretto, 2015, Molecular and Cellular Biochemistry.

Modulation of GABA Transport by Adenosine A1R–A2AR Heteromers, Which Are Coupled to Both Gs- and Gi/o-Proteins

C. Lluis, R. Franco, V. Casadó, 2011, The Journal of Neuroscience.

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

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A New Viewpoint on the Etiopathogenesis of Depression: Insights From the Neurophysiology of Deep Brain Stimulation in Parkinson's Disease and Treatment-Resistant Depression

R. Gusmão, Amílcar Silva-Dos-Santos, A. Sebastião, 2021, Frontiers in Psychiatry.

Interleukin‐6‐type cytokines in neuroprotection and neuromodulation: oncostatin M, but not leukemia inhibitory factor, requires neuronal adenosine A1 receptor function

Y. Sekino, H. Boddeke, K. Biber, 2010, Journal of neurochemistry.

BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes

Rita I Aroeira, C. Valente, A. Sebastião, 2015, Glia.

Adenosine A1 Receptor Suppresses Tonic GABAA Receptor Currents in Hippocampal Pyramidal Cells and in a Defined Subpopulation of Interneurons.

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Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes*

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Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP

C. Duarte, D. Rombo, Blanka Kellermayer, 2015, The Journal of Neuroscience.

On the role of stigmergy in cognition

Pedro F. Santana, Luís Correia, Ana M. Sebastião, 2017, Progress in Artificial Intelligence.

BDNF modulates glycine uptake in hippocampal synaptosomes by decreasing membrane insertion of glycine transporter 2

Rita I Aroeira, C. Valente, A. Sebastião, 2016, Neurochemistry International.

Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography

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Hypoxia–Ischemia Alters Nucleotide and Nucleoside Catabolism and Na+,K+-ATPase Activity in the Cerebral Cortex of Newborn Rats

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GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents.

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Dissecting striatal adenosine‐cannabinoid receptor interactions. New clues from rats over‐expressing adenosine A2A receptors

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Depression Assessment in Clinical Trials and Pre-clinical Tests: A Critical Review.

D. Telles-Correia, A. Sebastião, L. Castanheira, 2018, Current topics in medicinal chemistry.

Endogenous Adenosine Modulation of 22Na Uptake by Rat Brain Synaptosomes

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Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus

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Role of A2a Receptors in the Hippocampus and Motor Nerve Endings

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Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve

J. Ribeiro, A. Sebastião, 1985, British journal of pharmacology.

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

V. Neves, T. Outeiro, M. Castanho, 2020, Frontiers in Pharmacology.

Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation

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Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity

D. Pereira, J. Ribeiro, A. Sebastião, 2013, Purinergic Signalling.

Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation

R. Ramalho, J. Ribeiro, A. Sebastião, 2015, Growth factors.

Cognitive comorbidities of experimental absence seizures are independent of anxiety

V. Crunelli, G. Giovanni, A. Sebastião, 2023, Neurobiology of Disease.

Rita I Aroeira, C. Valente, J. Ribeiro, 2011, Journal of neurochemistry.

Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices

T. F. Pais, Rita F. Belo, A. Sebastião, 2020, Frontiers in Neuroscience.

Cognitive comorbidities of experimental absence seizures are independent of anxiety

V. Crunelli, G. Giovanni, A. Sebastião, 2023, Neurobiology of Disease.

Neuroinflammation after neonatal hypoxia–ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult

M. Schetinger, D. Zanini, M. B. Moretto, 2015, Molecular and Cellular Biochemistry.

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

A. Köfalvi, C. Müller, J. Ribeiro, 2019, Neuropharmacology.

Caffeine and adenosine.

J. Ribeiro, A. Sebastião, 2010, Journal of Alzheimer's disease : JAD.

Dissecting neurovascular coupling mechanisms: a role for adenosine A2A receptor

N. Dale, A. Sebastião, 2017, Journal of neurochemistry.

Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation

J. Ribeiro, A. Sebastião, 2015, Brain Research.

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

C. Lluis, R. Franco, V. Casadó, 2013, Purinergic Signalling.

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

C. Limatola, B. Frenguelli, L. Maggi, 2014, Cerebral cortex.

Modulation and metamodulation of synapses by adenosine

J. Ribeiro, A. Sebastião, 2010, Acta physiologica.

Activation of Adenosine A2A Receptor Facilitates Brain-Derived Neurotrophic Factor Modulation of Synaptic Transmission in Hippocampal Slices

J. Ribeiro, A. Sebastião, C. Fernandes, 2004, The Journal of Neuroscience.

Adenosine A2A receptors in neuronal outgrowth: a target for nerve regeneration?

A. Sebastião, Filipa F Ribeiro, 2016, Neural regeneration research.

Adenosine and epilepsy—thinking beyond A1 receptors

A. Sebastião, 2010, Purinergic Signalling.

Postsynaptic Action of Brain-Derived Neurotrophic Factor Attenuates α7 Nicotinic Acetylcholine Receptor-Mediated Responses in Hippocampal Interneurons

A. Pinto-Duarte, J. Ribeiro, A. Sebastião, 2008, The Journal of Neuroscience.

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors

D. Rombo, R. Dias, J. Ribeiro, 2016, Purinergic Signalling.

Synaptic mechanisms of adenosine A2A receptor‐mediated hyperexcitability in the hippocampus

K. Lamsa, L. Minichiello, D. Rombo, 2015, Hippocampus.

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

A. Sebastião, C. Valente, D. Rombo, 2018, Journal of Neuroinflammation.

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

R. Dias, J. Ribeiro, A. Sebastião, 2013, Neuropharmacology.

Cognitive comorbidities of experimental absence seizures are independent of anxiety

V. Crunelli, G. Giovanni, A. Sebastião, 2023, Neurobiology of Disease.

THEMED ISSUE: GPCR REVIEW Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection

A. Sebastião, J. A. Ribeiro, 2009 .