Z. Qiu

发表

3-[(3S)-3-Ethyl-1-methylazepan-3-yl]phenyl N-(4-fluorophenyl)carbamate

Jian Sun, Qiong Xie, Zhui-Bai Qiu, 2010, Acta crystallographica. Section E, Structure reports online.

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

Wei-Chang Fu, Wei Li, Lin-qian Yu, 2021, Journal of medicinal chemistry.

3D–QSAR studies of orvinol analogs as κ-opioid agonists

Qiong Xie, Yun Tang, Wei Li, 2006 .

Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept.

Wei Li, Wei-Chang Fu, Deng-Qi Xue, 2019, Journal of medicinal chemistry.

Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α,14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group

Yun Tang, Hong-Zhuan Chen, Yu Qiu, 2011, Medicinal Chemistry Research.

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

Yun Tang, J. Sussman, Wei-Chang Fu, 2009, Journal of medicinal chemistry.

Bis(9)-(−)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice

Juan Li, Ting Liu, Hong-Zhuan Chen, 2013, Pharmacology Biochemistry and Behavior.

QSAR study of 4-phenylpiperidine derivatives as mu opioid agonists by neural network method.

Yun Tang, Qiong Xie, Z. Qiu, 2006, European journal of medicinal chemistry.

The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.

Wei-Chang Fu, Yonghui Wang, Wei Li, 2017, ACS chemical neuroscience.

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.

Wei-Chang Fu, Wei Li, Siyuan Tang, 2022, Journal of medicinal chemistry.

7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.

Wei-Chang Fu, Wei Li, Deng-Qi Xue, 2018, Bioorganic & medicinal chemistry.

Theoretical and NMR investigations on the conformations of ( − )-meptazinol hydrochloride in solution

Yun Tang, C. Lau, Lili Xu, 2013 .

Antinociceptive effects of meptazinol and its isomers on carrageenan-induced thermal hyperalgesia in rats.

Yu-Qiu Zhang, Z. Qiu, Zhi-qi Zhao, 2004, Sheng li xue bao : [Acta physiologica Sinica].

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Wei-Chang Fu, Hong-Zhuan Chen, Z. Xia, 2017, Journal of enzyme inhibition and medicinal chemistry.

Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.

Yun Tang, Wei-Chang Fu, Wei Zhou, 2008, Journal of medicinal chemistry.

Highly regio- and diastereoselective halohydroxylation of olefins: a facile synthesis of vicinal halohydrins

Z. Qiu, Yang Wang, Jie Wang, 2011 .

Determination of Meserine, a new candidate for Alzheimer’s disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study

Jianrong Xu, Hongzhuan Chen, Ya-Bin Tang, 2014, Analytical and Bioanalytical Chemistry.

Conformational re-analysis of (+)-meptazinol: an opioid with mixed analgesic pharmacophores

C. Lau, Wei Li, Qiong Xie, 2006, Acta Pharmacologica Sinica.

Inhibitory effect of intrathecal meptazinol on carrageenan-induced thermal hyperalgesia in rats

Yu-Qiu Zhang, Z. Qiu, Hua Zhang, 2004, Neuroscience Letters.

Structural comparisons of meptazinol with opioid analgesics

Wei Li, Yan Chen, Z. Qiu, 2005, Acta Pharmacologica Sinica.

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.

Qiong Xie, Z. Qiu, Xing-hai Wang, 2005, Bioorganic & medicinal chemistry letters.

Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists.

Yun Tang, Zhui-Bai Qiu, Yun Tang, 2006, Bioorganic & medicinal chemistry.

Major Depressive Disorder and Kappa Opioid Receptor Antagonists

Wei Li, Renyu Liu, Xicheng Yang, 2016, Translational perioperative and pain medicine.

Meserine, a Novel Carbamate AChE Inhibitor, Ameliorates Scopolamine‐Induced Dementia and Alleviates Amyloidogenesis of APP/PS1 Transgenic Mice

Hong-Zhuan Chen, Z. Xia, Hao Wang, 2014, CNS neuroscience & therapeutics.

Investigation of the binding mode of (−)-meptazinol and bis-meptazinol derivatives on acetylcholinesterase using a molecular docking method

Yun Tang, Wei Li, Qiong Xie, 2006, Journal of molecular modeling.

Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer’s Disease

Zhe Wu, Jianrong Xu, Meng-Yao Shen, 2019, Front. Aging Neurosci..

Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Yun Tang, Wei-Chang Fu, Wei Li, 2010, Bioorganic & medicinal chemistry letters.

Highly Selective and Potent μ Opioid Ligands by Unexpected Substituent on Morphine Skeleton.

Z. Qiu, 2010 .

Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.

Wei Zhou, Z. Xia, Wei Li, 2012, Toxicology and applied pharmacology.

Bis(9)-(−)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice

Jianrong Xu, Hongzhuan Chen, Qiong Xie, 2018, Translational Neurodegeneration.

Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study.

Hong-Zhuan Chen, Zheng-xing Rong, T. Jiang, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

An efficient synthesis of 5α-androst-1-ene-3,17-dione

Z. Qiu, Huyue Zhang, 2006, Steroids.

HIGH-YIELD SYNTHESIS OF ANDROST-4-ENE-3,6,17-TRIONE AND ANDROST-4-ENE-3B,6B,17B- TRIOL

Z. Qiu, Guanghui Deng, Huyue Zhang, 2008 .

High-Yield Synthesis of Androst-4-ene-3,6,17-trione (IV) and Androst-4-ene-3β,6β,17β-triol.

Z. Qiu, Guanghui Deng, Huyue Zhang, 2008 .

Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice.

C. Dong, Hong-Zhuan Chen, Z. Xia, 2009, The international journal of neuropsychopharmacology.

Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC-MS/MS: application to pharmacokinetic study after intravenous and subcutaneous administration.

Hongzhuan Chen, Qiong Xie, Z. Qiu, 2014, Journal of pharmaceutical and biomedical analysis.

Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging.

Wei-Chang Fu, Wei Li, Li-ying Xiao, 2021, ACS chemical neuroscience.