R. Tsushima

发表

Botulinum Neurotoxin A and Neurotoxin E Cleavage Products of Synaptosome-Associated Protein of 25 kd Exhibit Distinct Actions on Pancreatic Islet &bgr;-Cell Kv2.1 Channel Gating

C. Elias, Y. Leung, Youhou Kang, 2008, Pancreas.

Cross-talk between glycogen synthase kinase 3 β ( GSK 3 β ) and p 38 MAPK regulates myocyte enhancer factor 2 ( MEF 2 ) activity in skeletal and cardiac muscle

J. Zhao, A. Kerr, S. Hashemi, 2012 .

Antagonism of Rat β-Cell Voltage-dependent K+ Currents by Exendin 4 Requires Dual Activation of the cAMP/Protein Kinase A and Phosphatidylinositol 3-Kinase Signaling Pathways*

P. MacDonald, E. Targonsky, M. Wheeler, 2003, Journal of Biological Chemistry.

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.

R. Khokha, J. Penninger, J. Scholey, 2007, Cardiovascular research.

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

M. Wheeler, J. M. Fox, Y. Leung, 2007, Endocrinology.

Phosphatidylinositol 3-Kinase &ggr; Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning

J. Penninger, S. Izumo, G. Oudit, 2008, Circulation research.

SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion.

H. Gaisano, Christin Chao, R. Tsushima, 2011, Journal of molecular and cellular cardiology.

Transgenic mouse overexpressing syntaxin-1A as a diabetes model.

J. Ellis, Y. Leung, L. Sheu, 2005, Diabetes.

ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell KATP Channels*

S. Shyng, Nathan Chang, T. Liang, 2010, The Journal of Biological Chemistry.

Inhibition of Kv2.1 Voltage-dependent K+Channels in Pancreatic β-Cells Enhances Glucose-dependent Insulin Secretion*

Catherine B. Chan, P. MacDonald, G. Sakellaropoulos, 2002, The Journal of Biological Chemistry.

Subconductance activity induced by quinidine and quinidinium in purified cardiac sarcoplasmic reticulum calcium release channels.

J. Kelly, R. Tsushima, J. Wasserstrom, 2002, The Journal of pharmacology and experimental therapeutics.

Exogenous glucocorticoids and a high-fat diet cause severe hyperglycemia and hyperinsulinemia and limit islet glucose responsiveness in young male Sprague-Dawley rats.

Jacqueline L. Beaudry, M. Riddell, Trevor Teich, 2013, Endocrinology.

The phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism

P. MacDonald, P. Light, M. Wheeler, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Phosphatidylinositol 3-Kinase (cid:1) Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning Integrative Physiology

J. Penninger, S. Izumo, G. Oudit, 2008 .

Role of Phosphoinositide 3-Kinase &agr;, Protein Kinase C, and L-Type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility

J. Woodgett, A. Shah, G. Oudit, 2010, Hypertension.

Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis*

M. Wheeler, L. Sheu, H. Gaisano, 2004, Journal of Biological Chemistry.

Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.

N. Diamant, M. Hara, Y. Leung, 2006, Endocrinology.

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Pancreatic β-Cells

P. MacDonald, J. Stieber, M. Wheeler, 2007 .

The impact of age and frailty on ventricular structure and function in C57BL/6J mice

R. Rose, S. Howlett, A. Kane, 2017, The Journal of physiology.

The impact of age and frailty on ventricular structure and function in C 57 BL / 6 J mice

R. Rose, S. Howlett, A. Kane, 2017 .

Modulation of Iron Uptake in Heart by L-Type Ca 2 (cid:49) Channel Modifiers Possible Implications in Iron Overload

G. Oudit, P. Backx, A. Wickenden, 1999 .

Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease

E. Vigmond, M. Gollob, P. Backx, 2018, PloS one.

Antibodies against Tityus discrepans venom do not abolish the effect of Tityus serrulatus venom on the rat sodium and potassium channels.

P. Backx, A. Borges, R. Tsushima, 1999, Toxicon : official journal of the International Society on Toxinology.

Visualization of Sequential Exocytosis in Rat Pancreatic Islet β Cells

Y. Leung, L. Sheu, H. Gaisano, 2002 .

Visualization of sequential exocytosis in rat pancreatic islet beta cells.

Y. Leung, L. Sheu, H. Gaisano, 2002, Biochemical and biophysical research communications.

Two populations of pancreatic islet α-cells displaying distinct Ca2+ channel properties☆

N. Diamant, Y. Leung, L. Sheu, 2006 .

Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation

G. Oudit, V. Chauhan, Xiaodong Gao, 2011, PloS one.

Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes.

J. Kelly, J. Salata, R. Tsushima, 1999, The Journal of pharmacology and experimental therapeutics.

Cloning and characterization of a Family C orphan G‐protein coupled receptor

D. Hampson, Janice B. B. Lam, R. Tsushima, 2005, Journal of neurochemistry.

Activation of cardiac ryanodine receptors by cardiac glycosides.

J. Kelly, K. Sagawa, R. Tsushima, 2002, American journal of physiology. Heart and circulatory physiology.

Syntaxin-1A Inhibits Cardiac KATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A*

P. Light, Y. Leung, Youhou Kang, 2004, Journal of Biological Chemistry.

Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation*

Y. Leung, A. Tinker, Youhou Kang, 2006, Journal of Biological Chemistry.

Concentration‐Dependent Effects of Purine/Xanthine Oxidase on Release of 6‐Keto-PGF1α and Contractile Function of Isolated Guinea Pig Hearts: Response to “Ischemic” Conditions Followed by Reperfusion

R. Tsushima, M. Moffat, 1989, Journal of cardiovascular pharmacology.

Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties.

N. Diamant, Y. Leung, L. Sheu, 2006, Biochemical and biophysical research communications.

Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.

S. Unniappan, Xiaodong Gao, R. Tsushima, 2011, The Journal of endocrinology.

RAPID COMMUNICATION Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet b- and MIN6 cells

S. Unniappan, Xiaodong Gao, R. Tsushima, 2011 .

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

P. MacDonald, E. Targonsky, M. Wheeler, 2003, The Journal of biological chemistry.

Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats.

S. Unniappan, R. Ceddia, Xiaodong Gao, 2011, Endocrinology.

H 3 Domain of Syntaxin 1 A Inhibits KATP Channels by Its Actions on the Sulfonylurea Receptor 1 Nucleotide-Binding Folds-1 and-2 *

P. Wahl, Y. Leung, N. Cui, 2004 .

Preferential regulation of rabbit cardiac L‐type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway

G. Wilson, P. Backx, R. J. Diaz, 1998, The Journal of physiology.

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

H. Gaisano, Xiaodong Gao, R. Tsushima, 2008, Endocrinology.

Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking*

Sharon Tsuk, I. Lotan, Y. Leung, 2003, The Journal of Biological Chemistry.

Characteristics of cocaine block of purified cardiac sarcoplasmic reticulum calcium release channels.

J. Kelly, R. Tsushima, J. Wasserstrom, 1996, Biophysical journal.

The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure.

G. Fishman, P. Backx, Z. Kassiri, 1998, Cardiovascular research.

Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.

R. Sah, P. Backx, R. Tsushima, 1998, American journal of physiology. Cell physiology.

Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.

G. Oudit, P. Backx, P. Liu, 1999, Circulation research.

and Implications in Iron Overload Channel Modifiers : Possible 2 + Modulation of Iron Uptake in Heart by L-Type Ca

G. Oudit, P. Backx, Peter P. Liu, 1999 .

The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states.

E. Marbán, L. J. McCutcheon, R. Sah, 1996, The Journal of physiology.

Effect of Cd2+ on Kv4.2 and Kv1.4 Expressed in Xenopus Oocytes and on the Transient Outward Currents in Rat and Rabbit Ventricular Myocytes

P. Backx, A. Wickenden, V. Losito, 1999, Cellular Physiology and Biochemistry.

A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.

G. Tomaselli, P. Backx, Ronald A. Li, 2004, Molecular pharmacology.

Local anesthetic anchoring to cardiac sodium channels. Implications into tissue-selective drug targeting.

P. Backx, R. Tsushima, K. Himmeldirk, 1999, Circulation research.

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.

R. Kallen, P. Backx, Ronald A. Li, 1997, Biophysical journal.

P-loop Flexibility in Na+ Channel Pores Revealed by Single- and Double-cysteine Replacements

P. Backx, Ronald A. Li, R. Tsushima, 1997, The Journal of general physiology.

Altered Ionic Selectivity of the Sodium Channel Revealed by Cysteine Mutations within the Pore

P. Backx, Ronald A. Li, R. Tsushima, 1997, The Journal of general physiology.

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.

R. Robinson, Qinghua Wang, J. Diao, 2009, The Journal of endocrinology.

Functional characterization of hyp erpolarization-activated cyclic nucleotide-gated channels in rat pancreatic b cells

R. Robinson, Qinghua Wang, J. Diao, 2009 .

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

P. Pennefather, C. Chan, M. Wheeler, 2001, Diabetes.

Second-phase insulin secretion gets cool.

R. Tsushima, 2011, American journal of physiology. Endocrinology and metabolism.

H3 Domain of Syntaxin 1A Inhibits KATP Channels by Its Actions on the Sulfonylurea Receptor 1 Nucleotide-Binding Folds-1 and -2*

P. Wahl, Y. Leung, N. Cui, 2004, Journal of Biological Chemistry.

Functional and electrophysiological effects of quinacrine on the response of ventricular tissues to hypoxia and reoxygenation.

R. Tsushima, M. Moffat, 1989, Canadian Journal of Physiology and Pharmacology.

The 25-kDa Synaptosome-associated Protein (SNAP-25) Binds and Inhibits Delayed Rectifier Potassium Channels in Secretory Cells*

N. Diamant, W. Trimble, A. Salapatek, 2002, The Journal of Biological Chemistry.

Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels.

Y. Leung, Youhou Kang, L. Sheu, 2005, The Biochemical journal.

Differential Effects of Purine/Xanthine Oxidase on the Electrophysiologic Characteristics of Ventricular Tissues

R. Tsushima, M. Moffat, 1990, Journal of cardiovascular pharmacology.

Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.

Y. Leung, Youhou Kang, H. Gaisano, 2006, The Biochemical journal.

Tissue-Selective Drug Targeting Local Anesthetic Anchoring to Cardiac Sodium Channels : Implications Into

P. Backx, Ronald A. Li, R. Tsushima, 1999 .

Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.

R. Sah, P. Backx, R. Tsushima, 1998, The American journal of physiology.

Inactivated state dependence of sodium channel modulation by β-scorpion toxin

P. Backx, A. Borges, R. Tsushima, 1999, Pflügers Archiv.

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines

M. Wheeler, G. Holz, J. Ji, 2002, Diabetologia.

Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle.

J. Zhao, A. Kerr, S. Hashemi, 2013, Journal of molecular and cellular cardiology.

Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse.

N. Diamant, M. Hara, Y. Leung, 2005, Endocrinology.

Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.

N. Diamant, Y. Leung, Youhou Kang, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Distinct modulation of Kv 1 . 2 channel gating by wild type , but not open form , of syntaxin-1 A

N. Diamant, Y. Leung, Youhou Kang, 2007 .

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

H. Gaisano, Xiaodong Gao, R. Tsushima, 2008, Endocrinology.

Inactivated state dependence of sodium channel modulation by beta-scorpion toxin.

P. Backx, A. Borges, R. Tsushima, 1999, Pflugers Archiv : European journal of physiology.