M. Clos

发表

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

F. J. Luque, J. Juárez-Jiménez, R. Sabaté, 2014, European journal of medicinal chemistry.

AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice

P. Camps, D. Muñoz-Torrero, A. Badía, 2015, Behavioural Brain Research.

Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases β-adrenoceptor-linked cyclic AMP formation in middle-aged rats

M. Dierssen, N. Vivas, A. Badía, 1992, Brain Research.

Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats

M. Dierssen, N. Vivas, A. Badía, 1991, Neuroscience Letters.

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies.

F. J. Luque, I. Ferrer, R. Sabaté, 2015, Journal of medicinal chemistry.

Presynaptic Modulation of K+-Evoked [3H]Dopamine Release in Striatal and Frontal Cortical Synaptosomes of Normotensive and Spontaneous-Hypertensive Rats

A. Badía, M. Clos, Moulay A. Yousfi-Alaoui, 2001, Neurochemical Research.

Differential contribution of L- and N-type calcium channels on rat hippocampal acetylcholine release

J. Sabrià, A. Badía, M. Clos, 1994, Neuroscience Letters.

Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process

M. Salmona, D. Ruiz-Molina, A. Martínez-Otero, 2009, Molecular and Cellular Neuroscience.

Acetylcholinesterase triggers the aggregation of PrP 106-126.

P. Camps, M. Salmona, C. Manzoni, 2006, Biochemical and biophysical research communications.

Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents

P. Camps, D. Muñoz-Torrero, A. Badía, 2012, Neurodegenerative Diseases.

Effect of acetylcholinesterase inhibitors on AChE-Induced PrP106–126 aggregation

P. Camps, M. Salmona, D. Muñoz-Torrero, 2007, Journal of Molecular Neuroscience.

Effect of 1‐aminocyclopropanecarboxylic acid on N‐methyl‐d‐aspartate‐stimulated [3H]‐noradrenaline release in rat hippocampal synaptosomes

A. Badía, M. Clos, A. Sanz, 1996, British journal of pharmacology.

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

M. Bartolini, I. Silman, P. Renard, 2018, Molecules.

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

F. J. Luque, V. Andrisano, M. Bartolini, 2012, Journal of medicinal chemistry.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2009, Journal of medicinal chemistry.

Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3

P. Camps, D. Muñoz-Torrero, A. Badía, 2021, Brain sciences.

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2014, Journal of medicinal chemistry.

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

F. J. Luque, Vincenza Andrisano, Albert Badia, 2010, ChemMedChem.

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

F. J. Luque, V. Andrisano, M. Bartolini, 2010, Chemico-biological interactions.

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

C. Riera, D. Muñoz-Torrero, M. Taylor, 2015, European journal of medicinal chemistry.

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.

A. Fairlamb, S. Y. Gbedema, D. Muñoz-Torrero, 2015, Bioorganic & medicinal chemistry.

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.

S. Y. Gbedema, D. Muñoz-Torrero, M. Taylor, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

D. Muñoz-Torrero, M. Taylor, J. Kelly, 2016, Bioorganic & medicinal chemistry.

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

F. J. Luque, Ornella Di Pietro, R. Lamuela-Raventós, 2014, Bioorganic & medicinal chemistry.

Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease.

P. Camps, D. Muñoz-Torrero, A. Badía, 2017, Behavioural pharmacology.

Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer’s Disease in Triple Transgenic Mice (3xTg-AD)

P. Camps, D. Muñoz-Torrero, A. Badía, 2012, Neurodegenerative Diseases.

Effect of Huprine X on β-Amyloid, Synaptophysin and α7 Neuronal Nicotinic Acetylcholine Receptors in the Brain of 3xTg-AD and APPswe Transgenic Mice

A. Nordberg, P. Camps, D. Muñoz-Torrero, 2010, Neurodegenerative Diseases.

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

F. J. Luque, V. Andrisano, M. Bartolini, 2008, Journal of medicinal chemistry.

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.

F. J. Luque, V. Andrisano, M. Bartolini, 2014, European journal of medicinal chemistry.

Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

P. Camps, D. Muñoz-Torrero, A. Badía, 2018, International journal of molecular sciences.

Superfusion of synaptosomes to study presynaptic mechanisms involved in neurotransmitter release from rat brain.

A. Badía, M. Clos, A. García-Sanz, 2001, Brain research. Brain research protocols.

Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors

P. Camps, D. Muñoz-Torrero, A. Badía, 2005, Brain Research.

Differential effect of quinpirole and 7‐OH‐DPAT on the spontaneous [3H]‐dopamine efflux from rat striatal synaptosomes

A. Badía, M. Clos, A. García-Sanz, 2001, Synapse.

Presynaptic effect of 7-OH-DPAT on evoked [3H]-acetylcholine release in rat striatal synaptosomes

A. Badía, M. Clos, S. Hospital, 2000, Brain Research.

Potentiation effects of (±)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes

P. Camps, A. Badía, M. Clos, 2004, Neuropharmacology.

Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

P. Camps, D. Muñoz-Torrero, N. Vivas, 2005, Neuroscience Letters.

Involvement of Different Types of Voltage‐Sensitive Calcium Channels in the Presynaptic Regulation of Noradrenaline Release in Rat Brain Cortex and Hippocampus

J. Sabrià, A. Badía, M. Clos, 1995, Journal of neurochemistry.

Interaction of a new potent anticholinesterasic compound (±)huprine X with muscarinic receptors in rat brain

N. Vivas, A. Badía, M. Clos, 2002, Neuroscience Letters.

Role of calcium on the modulation of spontaneous acetylcholine efflux by the D2 dopamine receptor subtype in rat striatal synaptosomes

A. Badía, M. Clos, A. Sanz, 2000, Brain Research.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

V. Andrisano, M. Bartolini, F. Mancini, 2009, Journal of medicinal chemistry.