R. Pannell

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Activation of plasminogen by single-chain urokinase or by two-chain urokinase--a demonstration that single-chain urokinase has a low catalytic activity (pro-urokinase).

V. Gurewich, R. Pannell, 1987 .

Highly Effective Fibrinolysis by a Sequential Synergistic Combination of Mini-Dose tPA plus Low-Dose Mutant proUK

V. Gurewich, R. Pannell, Shelley Li, 2015, PloS one.

Pro-urokinase: a study of its stability in plasma and of a mechanism for its selective fibrinolytic effect.

V. Gurewich, R. Pannell, 1986, Blood.

Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species.

V. Gurewich, R. L. Suddith, R. Greenlee, 1984, The Journal of clinical investigation.

Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.

E. Angles-cano, F. Dignat-George, L. Camoin-Jau, 2007, Blood.

Characterization of the intrinsic fibrinolytic properties of pro-urokinase through a study of plasmin-resistant mutant forms produced by site-specific mutagenesis of lysine(158).

V. Gurewich, R. Pannell, R. Broeze, 1988, The Journal of clinical investigation.

Activation of plasminogen by single-chain urokinase or by two-chain urokinase--a demonstration that single-chain urokinase has a low catalytic activity (pro-urokinase).

V. Gurewich, R. Pannell, 1987, Blood.

A comparative study of the efficacy and specificity of tissue plasminogen activator and pro-urokinase: demonstration of synergism and of different thresholds of non-selectivity.

V. Gurewich, R. Pannell, 1986, Thrombosis research.

Complementary modes of action of tissue-type plasminogen activator and pro-urokinase by which their synergistic effect on clot lysis may be explained.

V. Gurewich, R. Pannell, J. Black, 1988, The Journal of clinical investigation.

Inactivation of single-chain urokinase (pro-urokinase) by thrombin and thrombin-like enzymes: relevance of the findings to the interpretation of fibrin-binding experiments.

V. Gurewich, R. Pannell, 1987, Blood.

Properties of Human α1-Antitrypsin

J. Travis, David A. Johnson, R. Pannell, 1974 .

Isolation and properties of human plasma α-1-proteinase inhibitor

J. Travis, David A. Johnson, R. Pannell, 1974 .

Lipoprotein(a): a kinetic study of its influence on fibrin-dependent plasminogen activation by prourokinase or tissue plasminogen activator.

P. Harpel, V. Gurewich, J. Liu, 1993, Biochemistry.

C1‐inhibitor prevents non‐specific plasminogen activation by a prourokinase mutant without impeding fibrin‐specific fibrinolysis

V. Gurewich, R. Pannell, W. Kung, 2007, Journal of thrombosis and haemostasis : JTH.

Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator

S. Badylak, P. Sarmientos, A. Simmons-Byrd, 2006, Journal of thrombosis and haemostasis : JTH.

Structure‐function relationships in thrombin‐activatable fibrinolysis inhibitor: comment

V. Gurewich, R. Pannell, 2016, Journal of thrombosis and haemostasis : JTH.

A comparison of the rates of clot lysis in a plasma milieu induced by tissue plasminogen activator (t-PA) and rec-pro-urokinase: Evidence that t-PA has a more restricted mode of action

V. Gurewich, R. Pannell, 1992 .

Synergism of Tissue-Type Plasminogen Astivator (t-PA) and Single-Chain Urokinase-Type Plasminogen Activator (scu-PA) on Clot Lysis In Vitro and a Mechanism for this Effect

V. Gurewich, R. Pannell, 1987, Thrombosis and Haemostasis.

The molecular stoichiometry of trypsin inhibition by human alpha-1-proteinase inhibitor.

D. Johnson, J. Travis, R. Pannell, 1974, Biochemical and biophysical research communications.

Pro‐urokinase and prekallikrein are both associated with platelets

V. Gurewich, R. Pannell, M. Johnstone, 1993, FEBS letters.

Platelet-Bound Prekallikrein Promotes Pro-Urokinase-Induced Clot Lysis: A Mechanism for Targeting the Factor XII Dependent Intrinsic Pathway of Fibrinolysis

M. Johnstone, V. Gurewich, R. Pannell, 1994, Thrombosis and Haemostasis.

Spontaneous clot lysis in whole human plasma by endogenous tissue type and urokinase type plasminogen activators: Demonstration of a promoting effect by t-PA and by platelets on urokinase

F. Emmons, V. Gurewich, R. Pannell, 1988 .

Assembly and Activation of the Intrinsic Fibrinolytic Pathway on the Surface of Human Endothelial Cells in Culture

V. Gurewich, R. Pannell, C. Lenich, 1995, Thrombosis and Haemostasis.

activator in platelet membranes Evidence for a novel binding protein to urokinase-type plasminogen

V. Gurewich, R. Pannell, Jn Liu, 2011 .

Evidence for a novel binding protein to urokinase-type plasminogen activator in platelet membranes.

V. Gurewich, J. Liu, R. Pannell, 1996, Blood.

The Selective Uptake of High Molecular Weight Urokinase-type Plasminogen Activator by Human Platelets

M. Johnstone, V. Gurewich, R. Pannell, 1995 .

The Intrinsic Lysis Concept a

Jian-ning Liu, V. Gurewich, R. Pannell, 1992, Annals of the New York Academy of Sciences.

A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity.

P. Sarmientos, Z. Sun, V. Gurewich, 1996, Biochemistry.

The effect of the carboxy-terminal lysine of urokinase on the catalysis of plasminogen activation.

V. Gurewich, R. Pannell, C. Lenich, 1991, Thrombosis research.

Primary human marrow cultures for erythroid bursts in a serum-substituted system.

A. Cohen, N. Dainiak, R. Pannell, 1985, Experimental hematology.

activity (pro-urokinase) urokinase--a demonstration that single-chain urokinase has a low catalytic Activation of plasminogen by single-chain urokinase or by two-chain

V. Gurewich, R. Pannell, 2011 .

fibrin-binding experiments thrombin-like enzymes: relevance of the findings to the interpretation of Inactivation of single-chain urokinase (pro-urokinase) by thrombin and

V. Gurewich, R. Pannell, 2011 .

Fibrin Binding and Zymogenic Properties of Single-Chain Urokinase (Pro-urokinase)

V. Gurewich, R. Pannell, 1987, Seminars in thrombosis and hemostasis.

Thrombospondin forms complexes with single-chain and two-chain forms of urokinase.

R. Silverstein, R. Nachman, P. Harpel, 1990, The Journal of biological chemistry.

Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.

D. Johnson, J. Travis, D. Tewksbury, 1976, The Biochemical journal.

Recombinant human C1-inhibitor prevents non-specific proteolysis by mutant pro-urokinase during optimal fibrinolysis

V. Gurewich, R. Pannell, 2009, Thrombosis and Haemostasis.

A transitional state of pro-urokinase that has a higher catalytic efficiency against glu-plasminogen than urokinase.

V. Gurewich, J. Liu, R. Pannell, 1992, The Journal of biological chemistry.

Platelet Associated u-PA Up-regulates u-PA Synthesis by Endothelial Cells

F. Dignat-George, L. Camoin-Jau, J. Sampol, 2002, Thrombosis and Haemostasis.

Evidence for the Expression of Urokinase-type Plasminogen Activator by Human Venous Endothelial Cells In Vivo

F. Dignat-George, J. Sampol, L. Camoin, 1998, Thrombosis and Haemostasis.

The Influence of Glycosylation on the Catalytic and Fibrinolytic Properties of Pro-Urokinase

J. Henkin, V. Gurewich, R. Pannell, 1992, Thrombosis and Haemostasis.

Isolation and properties of human plasma alpha-1-proteinase inhibitor.

D. Johnson, J. Travis, R. Pannell, 1974, Biochemistry.

Fibrin-specific and effective clot lysis requires both plasminogen activators and for them to be in a sequential rather than simultaneous combination

V. Gurewich, R. Pannell, S. Li, 2017, Journal of Thrombosis and Thrombolysis.

The pH Dependence of the Binding of Pro-Urokinase to Fibrin/Celite

V. Gurewich, R. Pannell, E. Anglés-Cano, 1990, Thrombosis and Haemostasis.

An efficient system for production of recombinant urokinase-type plasminogen activator.

Jian-ning Liu, Ziyong Sun, V. Gurewich, 1997, Protein expression and purification.

Fibrin activatable urokinase (FA-UK): a latent form of UK found in urine related to a complex with an inhibitor/fibrin-interacting cofactor.

C. Dwivedi, V. Gurewich, R. Pannell, 1988, Thrombosis research.

114 Comparison of activation of plasminogen by forms of urokinase (UK) with and without the C-terminal lysine of the A-chain

V. Gurewich, R. Pannell, 1988 .

Processing and secretion of alpha-mannosidase forms by Dictyostelium discoideum.

R. Pannell, A. Kaplan, L. Wood, 1982, The Journal of biological chemistry.