S. Chatfield

发表

Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.

G. Dougan, D. Pickard, Tao Wu, 2004, Vaccine.

Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression

G. Dougan, D. Maskell, D. Pickard, 1994, Infection and immunity.

Salmonella enterica Serovar TyphimuriumsurA Mutants Are Attenuated and Effective Live Oral Vaccines

G. Dougan, G. Douce, Saddif Ahmed, 2000, Infection and Immunity.

Mucosal immunity: regulation by helper T cells and a novel method for detection.

M. Marinaro, J. Mcghee, H. Kiyono, 1996, Journal of biotechnology.

Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen.

G. Dougan, I. Frazer, R. Tindle, 1996, Vaccine.

Role of hns in the virulence phenotype of pathogenic salmonellae

G. Dougan, C. Higgins, C. Dorman, 1994, Molecular microbiology.

Influence of preimmunization with tetanus toxoid on immune responses to tetanus toxin fragment C-guest antigen fusions in a Salmonella vaccine carrier

J. Chabalgoity, C. Hormaeche, S. Chatfield, 1995, Infection and immunity.

Phase 2 Clinical Trial of AttenuatedSalmonella enterica Serovar Typhi Oral Live Vector Vaccine CVD 908-htrA in U.S. Volunteers

G. Dougan, M. Levine, C. Tacket, 2000, Infection and Immunity.

of Healthy Volunteers ) Mutations by ssaV Secretion System ( Pathogenicity Island 2 Type III Salmonella and aroC Derivatives Harboring Defined Salmonella enterica Characterization of

Marjan, Immunization., G. Dougan, 2002 .

Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans

G. Dougan, M. Levine, C. Tacket, 1997, Infection and immunity.

Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors.

G. Dougan, M. Levine, C. Tacket, 1996, Journal of biotechnology.

Construction and characterization of vaccine strains of Salmonella harboring mutations in two different aro genes.

G. Dougan, D. Maskell, D. Pickard, 1988, The Journal of infectious diseases.

Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier

N. Fairweather, G. Dougan, D. Maskell, 1990, Infection and immunity.

Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine.

I. Charles, N. Fairweather, G. Dougan, 1992, Vaccine.

Live Salmonella as vaccines and carriers of foreign antigenic determinants.

G. Dougan, R. Strugnell, S. Chatfield, 1989, Vaccine.

Carbohydrate Biopolymers Enhance Antibody Responses to Mucosally Delivered Vaccine Antigens

M. Roberts, L. Illum, I. Jabbal‐Gill, 2000, Infection and Immunity.

Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella.

G. Dougan, A. Capron, R. Pierce, 1994, Journal of immunology.

Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.

G. Dougan, R. Rappuoli, M. Pizza, 1995, Vaccine.

Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908

R. Rappuoli, M. Levine, G. Losonsky, 1996, Infection and immunity.

Salmonella typhi and S typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors.

G. Dougan, D. Pickard, Tao Wu, 2003, Vaccine.

Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain.

R. Rappuoli, M. Levine, J. Galen, 1995, Vaccine.

Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis

Ian G. Charles, I. Charles, N. Fairweather, 1992, Infection and immunity.

Use of the nirB Promoter to Direct the Stable Expression of Heterologous Antigens in Salmonella Oral Vaccine Strains: Development of a Single–Dose Oral Tetanus Vaccine

I. Charles, N. Fairweather, G. Dougan, 1992, Bio/Technology.

Construction of genetically defined double aro mutants of Salmonella typhi.

G. Dougan, M. Levine, S. Chatfield, 1991, Vaccine.

Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA.

G. Dougan, I. Cropley, M. Roberts, 1993, Vaccine.

Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo

G. Dougan, C. Dorman, S. Chatfield, 1991, Infection and immunity.

Prior Immunity to Homologous and HeterologousSalmonella Serotypes Suppresses Local and Systemic Anti-Fragment C Antibody Responses and Protection from Tetanus Toxin in Mice Immunized with Salmonella Strains Expressing Fragment C

S. Chatfield, A. Bacon, M. Roberts, 1999, Infection and Immunity.

Bacteriophage P22 as a vehicle for transducing cosmid gene banks between smooth strains of Salmonella typhimurium: Use in identifying a role for aroD in attenuating virulent Salmonella strains

G. Dougan, C. Hormaeche, S. Chatfield, 2004, Molecular and General Genetics MGG.

A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins

M. Marinaro, G. Dougan, R. Rappuoli, 1995, Infection and immunity.

The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.

J. O’Neill, B. Kirkpatrick, Z. Hindle, 2005, The Journal of infectious diseases.

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

J. Mcghee, H. Kiyono, M. Yamamoto, 1996, Journal of immunology.

T-cell and antibody response characterisation of a new recombinant pre-S1, pre-S2 and SHBs antigen-containing hepatitis B vaccine; demonstration of superior anti-SHBs antibody induction in responder mice.

S. Chatfield, M. Page, A. Bacon, 1999, Vaccine.

Characterization of the T‐ and B‐cell immune response to a new recombinant pre‐S1, pre‐S2 and SHBs antigen containing hepatitis B vaccine (Hepagene™); evidence for superior anti‐SHBs antibody induction in responder mice

S. Chatfield, M. Page, A. Bacon, 1998, Journal of viral hepatitis.

Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell monolayer

G. Dougan, B. Finlay, M. Starnbach, 1988, Molecular microbiology.

Attenuated Salmonella typhi and Shigella as live oral vaccines and as live vectors.

G. Dougan, M. Levine, C. Tacket, 1997, Behring Institute Mitteilungen.

The Genetics of Salmonella and Vaccine Development

G. Dougan, M. Roberts, G. Douce, 1993 .

Immunity Mechanisms in Experimental Salmonellosis

G. Dougan, G. Dougan, C. Hormaeche, 1993 .

Attenuated Salmonella typhi as Live Oral Vaccines to Prevent Typhoid Fever and as Carrier Vaccines to Express Foreign Antigens

G. Dougan, M. Levine, C. Tacket, 1993 .

The involvement of tumor necrosis factor in immunity to Salmonella infection.

G. Dougan, J. Tite, S. Chatfield, 1991, Journal of immunology.

Impaired resistance to infection does not increase the virulence of Salmonella htrA live vaccines for mice.

G. Dougan, J. Tite, C. Hormaeche, 1992, Microbial pathogenesis.

Synthesis of tetanus toxin fragment C in insect cells by use of a baculovirus expression system

I. Charles, N. Fairweather, A. Makoff, 1991, Infection and immunity.

Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C.

G. Dougan, M. Levine, C. Tacket, 2000, Clinical Immunology.

Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.

N. Fairweather, G. Riveau, R. Pierce, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Expression of LacZ from the htrA, nirB and groE promoters in a Salmonella vaccine strain: influence of growth in mammalian cells.

G. Dougan, P. Lund, J. Li, 1995, FEMS microbiology letters.

Live Attenuated Salmonellae: Oral Vaccines for Salmonellosis and Combined Vaccines Carrying Heterologous Antigens

G. Dougan, C. Hormaeche, S. Chatfield, 1992 .

Alternative methods of attenuating Salmonella species for potential vaccine use.

G. Dougan, B. Finlay, D. R. Wilson, 1990, Research in microbiology.

The development of oral vaccines based on live attenuated Salmonella strains.

G. Dougan, I. Cropley, M. Roberts, 1993, FEMS immunology and medical microbiology.

The Development of Genetically Defined Live Bacterial Vaccines

I. Charles, N. Fairweather, G. Dougan, 1991 .

Use of live attenuated bacteria to stimulate immunity.

I. Charles, N. Fairweather, G. Dougan, 1990, Research in microbiology.

Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo

G. Dougan, C. Higgins, C. Dorman, 1989, Infection and immunity.

Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.

I. Charles, G. Dougan, D. Pickard, 1992, Microbial pathogenesis.

Optimization of Salmonella enterica Serovar Typhi (cid:2) aroC (cid:2) ssaV Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters

G. Dougan, R. Stratford, J. Curtis, 2004 .

Molecular cloning and characterization of protective outer membrane protein P . 69 from Bordetella pertussis 1

N. Fairweather, D. Pickard, P. Morrissey, 2003 .

Role of the Bordetella pertussis P . 69 lpertactin protein and the P . 69 / pertactin RGD motif in the adherence to and invasion of mammalian cells

I. Charles, G. Dougan, J. Li, 2008 .

Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses

J. Mcghee, H. Kiyono, M. Yamamoto, 1996, Infection and immunity.

The Role of Th1 and Th2 Cells for Mucosal IgA Responses a

M. Marinaro, J. Mcghee, H. Kiyono, 1996, Annals of the New York Academy of Sciences.

Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium.

G. Dougan, P. W. Jones, S. Chatfield, 1991, Vaccine.

Protective Effect on Leishmania major Infection of Migration Inhibitory Factor, TNF-α, and IFN-γ Administered Orally via Attenuated Salmonella typhimurium

L. Tetley, G. Dougan, A. Satoskar, 1998, The Journal of Immunology.

Immune responses in calves immunised orally or subcutaneously with a live Salmonella typhimurium aro vaccine.

G. Dougan, S. Chatfield, B. Villarreal-Ramos, 1998, Vaccine.

Oral Vaccine Models: Multiple Delivery Systems Employing Tetanus Toxoid a

J. Mcghee, H. Kiyono, H. Staats, 1994 .

Oral vaccination

I. Charles, G. Dougan, D. Maskell, 2004, Antonie van Leeuwenhoek.

Biological and genetic characterization of TnphoA mutants of Salmonella typhimurium TML in the context of gastroenteritis

N. Brown, G. Dougan, J. Stephen, 1995, Infection and immunity.

Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-).

G. Dougan, F. Liew, S. McSorley, 1995, Immunology.

Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice.

G. Dougan, G. Fernando, R. Tindle, 1994, Virology.

Differential induction of carrier antigen-specific immunity by Salmonella typhimurium live-vaccine strains after single mucosal or intravenous immunization of BALB/c mice

B. Rouse, K. Karem, S. Chatfield, 1995, Infection and immunity.

Use of Double Aro Salmonella Mutants to Stably Express HPV16 E7 Protein Epitopes Carried by HBV Core Antigen

G. Dougan, I. Frazer, R. Tindle, 1994 .

Expression of human IL-1 beta in Salmonella typhimurium. A model system for the delivery of recombinant therapeutic proteins in vivo.

G. Dougan, F. Liew, M. Carrier, 1992, Journal of immunology.

Characterization of Candidate Live Oral Salmonella typhi Vaccine Strains Harboring Defined Mutations inaroA, aroC, and htrA

G. Dougan, M. Kagnoff, L. Eckmann, 1999, Infection and Immunity.

Regulation of host immune responses by modification of Salmonella virulence genes

J. Mcghee, H. Kiyono, Masafumi Yamamoto, 1998, Nature Medicine.

Salmonella genetics and vaccine development

G. Dougan, G. Douce, M. Sydenham, 1992 .

Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans

G. Dougan, R. Stratford, G. Griffin, 2007, Vaccine.

Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.

J. O’Neill, David N. Taylor, A. L. Bourgeois, 2006, Vaccine.

Optimization of Salmonella enterica Serovar Typhi ΔaroC ΔssaV Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters

G. Dougan, R. Stratford, Z. Hindle, 2005, Infection and Immunity.

Progress in the Development of Multivalent Oral Vaccines Based on Live Attenuated Salmonella

G. Dougan, S. Chatfield, M. Roberts, 1994 .

Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

D. Pickard, M. Roberts, S. Chatfield, 2000, Infection and Immunity.

Characterization of a Salmonella choleraesuis mutant that cannot multiply within epithelial cells.

G. Dougan, B. Finlay, S. Falkow, 1991, Canadian journal of microbiology.

Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.

I. Charles, N. Fairweather, G. Dougan, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The development of oral vaccines against parasitic diseases utilizing live attenuated Salmonella

G. Dougan, M. Roberts, C. Hormaeche, 1995, Parasitology.

Oral Vaccination against Tetanus: Comparison of the Immunogenicities of Salmonella Strains Expressing Fragment C from the nirB and htrAPromoters

S. Chatfield, A. Bacon, M. Roberts, 1998, Infection and Immunity.

Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi.

I. Charles, N. Fairweather, G. Dougan, 1991, Journal of general microbiology.

The use of live attenuated Salmonella for oral vaccination.

G. Dougan, J. Li, M. Roberts, 1994, Developments in biological standardization.

Oral Vaccination against Tetanus: Comparison of the Immunogenicities of Salmonella Strains Expressing Fragment C from the nirB and htrA Promoters

M. Roberts, S. Chatfield, A. Bacon, 1999, Infection and Immunity.

Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium.

L. Tetley, G. Dougan, A. Satoskar, 1998, Journal of Immunology.

Oral Vaccine Models: Multiple Delivery Systems Employing Tetanus Toxoid a

J. Mcghee, H. Kiyono, H. Staats, 1994, Annals of the New York Academy of Sciences.