P. Caspar

发表

Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL‐12 and up‐regulation of Th2 cytokines that inhibit macrophage activation

A. Sher, T. Wynn, I. Oswald, 1998, European journal of immunology.

Inducible Nitric Oxide Synthase-Deficient Mice Develop Enhanced Type 1 Cytokine-Associated Cellular and Humoral Immune Responses after Vaccination with AttenuatedSchistosoma mansoni Cercariae but Display Partially Reduced Resistance

T. Wynn, S. James, A. Cheever, 1998, Infection and Immunity.

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

A. Sher, G. Trinchieri, G. Besra, 2013, The Journal of Immunology.

The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments

A. Sher, C. Feng, G. Taylor, 2002, Infection and Immunity.

Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

A. Sher, F. Sutterwala, R. Flavell, 2010, The Journal of Immunology.

Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120.

A. Sher, F. Vogel, Dragana Jankovic, 1997, Journal of immunology.

Parasite-Induced Th2 Polarization Is Associated with Down-Regulated Dendritic Cell Responsiveness to Th1 Stimuli and a Transient Delay in T Lymphocyte Cycling

A. Sher, Dragana Jankovic, P. Caspar, 2004, The Journal of Immunology.

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

A. Sher, T. Mosmann, E. Pearce, 1991, Journal of immunology.

Toxoplasma gondii: evidence for interleukin-12-dependent and-independent pathways of interferon-gamma production induced by an attenuated parasite strain.

A. Sher, E. Denkers, P. Caspar, 1996, Experimental parasitology.

Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

A. Sher, B. Butcher, E. Denkers, 1997, Journal of immunology.

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni

A. Sher, E. Pearce, F. Lewis, 1991, The Journal of experimental medicine.

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

A. Sher, E. Pearce, F. Lewis, 1991, Journal of immunology.

In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.

A. Sher, Dragana Jankovic, P. Caspar, 2002, Immunity.

Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.

A. Sher, D. Barber, I. Sereti, 2010, Blood.

Persistent IL-12 Production Function in Chronic Tuberculosis Requires Maintenance of Pulmonary Th1 Effector

A. Sher, C. Feng, D. Jankovic, 2013 .

Maintenance of Pulmonary Th1 Effector Function in Chronic Tuberculosis Requires Persistent IL-12 Production

A. Sher, C. Feng, Dragana Jankovic, 2005, The Journal of Immunology.

IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

A. Sher, E. Pearce, T. Wynn, 1994, Journal of immunology.

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

A. Sher, P. Scott, P. Caspar, 1990, Journal of immunology.

Transgenic Mice Expressing Human Interleukin-10 in the Antigen-Presenting Cell Compartment Show Increased Susceptibility to Infection with Mycobacterium avium Associated with Decreased Macrophage Effector Function and Apoptosis

R. Coffman, A. Sher, C. Feng, 2002, Infection and Immunity.

Linked in vivo expression of soluble interleukin‐4 receptor and interleukin‐4 in murine schistosomiasis

R. Fernandez-Botran, A. Sher, T. Wynn, 1995, European journal of immunology.

A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection

A. Sher, E. Denkers, P. Caspar, 1996, The Journal of experimental medicine.

CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

A. Sher, T. Wynn, J. Ravetch, 1998, The Journal of experimental medicine.

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

A. Sher, T. Wynn, Dragana Jankovic, 1996, Journal of immunology.

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms.

A. Sher, T. Wynn, Dragana Jankovic, 1999, Journal of immunology.

Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V beta 5-bearing CD8+ lymphocytes

A. Sher, E. Denkers, P. Caspar, 1994, The Journal of experimental medicine.

This information is current as Lymphocytes with a Th2 Cytokine Profile the In Vivo or In Vitro Development of CD4+ Receptor/Stat6 Signaling Is Not Required for Single Cell Analysis Reveals That IL-4

W. Paul, P. Caspar, M. Kullberg, 2013 .

Transient Delay in T Lymphocyte Cycling Cell Responsiveness to Th1 Stimuli and a Associated with Down-Regulated Dendritic Parasite-Induced Th2 Polarization Is

A. Sher, D. Jankovic, P. Caspar, 2004 .

D. Chaussabel, A. Sher, W. Watford, 2008, Nature Immunology.

TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-γ production

A. Sher, G. Trinchieri, R. Goldszmid, 2007, The Journal of experimental medicine.

TAP-1 indirectly regulates CD4 (cid:2) T cell priming in Toxoplasma gondii infection by controlling NK cell IFN- (cid:2) production

A. Sher, G. Trinchieri, R. Goldszmid, 2007 .

Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation

A. Sher, T. Wynn, A. Rothfuchs, 2001, Infection and Immunity.

Immune Down-Modulation of Chronic Disease But Is Not Required for Schistosomiasis mansoni IL-10 Regulates Liver Pathology in Acute Murine

A. Sher, T. Wynn, R. Kühn, 1998 .

Structural Determinants of the Anti-HIV Activity of a CCR5 Antagonist Derived from Toxoplasma gondii*

J. Andersen, A. Sher, J. Aliberti, 2004, Journal of Biological Chemistry.

Require TLR Signaling In Vivo and Does Not Mycobacterium tuberculosis Production Is Critical for Host Resistance to β Cutting Edge : Caspase-1 Independent IL-1 Sutterwala and

Cheever, A. Sher, Gabriel, 2010 .

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

J. Andersen, A. Sher, J. Cannons, 2009, The Journal of experimental medicine.

Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile.

A. Sher, W. Paul, J. Ward, 1999, Journal of immunology.

Lymphokine Expression Profile Pathology While Maintaining the Same Mice, Fail to Develop Granulomatous KO Knockout (KO) Mice, in Contrast to IL-4 Schistosome-Infected IL-4 Receptor

A. Sher, W. Paul, J. Ward, 1999 .

Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.

A. Sher, E. Denkers, R. Gazzinelli, 1993, Journal of immunology.

Fcϵ receptor‐positive cells are a major source of antigen‐induced interIeukin‐4 in spleens of mice infected with Schistosoma mansoni

J. Berzofsky, A. Sher, R. Seder, 1993 .

IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12.

T. Wynn, K. Hoffmann, A. Cheever, 1998, Journal of immunology.

Downregulation of Thl Cytokine Production Accompanies Induction of Th2 Responses by a Parasitic Helrninth, Schistosoma mansoni

A. Sher, E. Pearce, P. Caspar, 2003 .

Subcortical Neuronal Projections to the Cerebral Cortex: Their Role in SDAT

B. Berger, P. Caspar, 1988 .

Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii–infected dendritic cells

I. Coppens, A. Sher, R. Goldszmid, 2009, The Journal of experimental medicine.

Mechanisms-Dependent Effector γ Cell-and IFN-Requires the Induction of Both B mansoni Schistosoma Optimal Vaccination Against Cheever and

A. Sher, T. Wynn, D. Jankovic, 1998 .

Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni

A. Sher, Dragana Jankovic, G. Yap, 1997, Infection and immunity.

Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-beta, which down-regulates macrophage antiparasitic activity.

A. Sher, O. Pankewycz, I. Oswald, 1995, Journal of immunology.

Recombinant Attenuated Toxoplasma gondii Expressing the Plasmodium yoelii Circumsporozoite Protein Provides Highly Effective Priming for CD8+ T Cell-Dependent Protective Immunity Against Malaria1

S. Hoffman, A. Sher, R. Gazzinelli, 2000, The Journal of Immunology.

Protective Immunity Against Malaria T Cell-Dependent + Effective Priming for CD 8 Circumsporozoite Protein Provides Highly Plasmodium yoelii Expressing the Toxoplasma gondii Recombinant Attenuated

S. Hoffman, A. Sher, R. Gazzinelli, 2000 .

Pillars article: downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159-166.

A. Sher, E. Pearce, F. Lewis, 2012, Journal of immunology.

Increased frequency of immunogenic variants obtained by repeated mutagen treatment of mouse mastocytoma P815.

T. Boon, P. Caspar, M. Marchand, 1983, European journal of cancer & clinical oncology.

Host Resistance and Immune Deviation in Pigeon Cytochromec T-Cell Receptor Transgenic Mice Infected withToxoplasma gondii

A. Sher, R. Schwartz, G. Yap, 2000, Infection and Immunity.

Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

J M Ward, A. Sher, J. Ward, 1998, Infection and Immunity.

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

A. Sher, J. Letterio, Dragana Jankovic, 2002, The Journal of experimental medicine.

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

A. Sher, A. Dzutsev, G. Trinchieri, 2012, Immunity.

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

A. Sher, S. Gordon, D. Barber, 2011, Immunity.

Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.

A. Sher, T. Wynn, I. Oswald, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

Carmen M. Collazo-Custodio, A. Sher, C. Feng, 2003, The Journal of Immunology.

TLR 4-Deficient Animals by Toll-Like Receptor 2 ( TLR 2 )-and Infection Not Exhibited Mycobacterium avium Resistance and Immune Responses to 88 Display Profound Defects in Host Mice Lacking Myeloid Differentiation Factor

Carmen M. Collazo-Custodio, A. Sher, C. Feng, 2003 .

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

A. Sher, G. Trinchieri, E. Denkers, 1994, Journal of immunology.

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

A. Sher, F. Finkelman, T. Wynn, 1994, Journal of immunology.

Treatment with anti-IL-2 antibodies reduces hepatic pathology and eosinophilia in Schistosoma mansoni-infected mice while selectively inhibiting T cell IL-5 production.

A. Sher, F. Finkelman, A. Cheever, 1992, Journal of immunology.

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

A. Sher, T. Wynn, F. Lewis, 1995, Nature.

Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni.

A. Sher, J. Coligan, E. Pearce, 1996, Journal of immunology.

Experimental amebiasis. III. A rapid in vitro assay for virulence of Entamoeba histolytica.

C. F. Mattern, D. Keister, P. Caspar, 1978, The American journal of tropical medicine and hygiene.

Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.

A. Sher, C. Lowenstein, T. Wynn, 1994, Journal of immunology.

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.

A. Sher, T. Wynn, R. Kühn, 1998, Journal of immunology.

Mechanism and Gamma Interferon-Dependent ( IL-10 )-Deficient Mice through an IL-12-Specific-Pathogen-Free Interleukin-10 Triggers Colitis in Helicobacter hepaticus

A. Sher, J. Ward, D. Jankovic, 1998 .

Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

A. Sher, W. Paul, Dragana Jankovic, 2000, The Journal of Immunology.

Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope

J. Andersen, A. Sher, J. Fox, 2003, Proceedings of the National Academy of Sciences of the United States of America.

-Dependent Effector γ Cell- and IFN- mansoni Requires the Induction of Both B Optimal Vaccination Against Schistosoma

Alan Sher, Sara Hieny, Patricia Caspar, 2013 .

Signaling and the Inflammasome Mycobacteria through Mincle/CARD9 the Th17-Promoting Adjuvant Activity of Cord Factor and Peptidoglycan Recapitulate

A. Sher, G. Trinchieri, G. Besra, 2013 .

Developmental differences determine larval susceptibility to nitric oxide-mediated killing in a murine model of vaccination against Schistosoma mansoni

A. Sher, I. Oswald, S. James, 1997, Infection and immunity.

Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology.

A. Sher, W. Paul, D. Dombrowicz, 1997, Journal of immunology.

T. Wynn, S. James, A. Cheever, 1998 .

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

A. Sher, S. Gordon, D. Barber, 2011, Immunity.

IFN-γ, IL-12, and TNF-α Are Required to Maintain Reduced Liver Pathology in Mice Vaccinated with Schistosoma mansoni Eggs and IL-12

T. Wynn, K. Hoffmann, A. Cheever, 1998, The Journal of Immunology.