S. Hieny

发表

Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL‐12 and up‐regulation of Th2 cytokines that inhibit macrophage activation

A. Sher, T. Wynn, I. Oswald, 1998, European journal of immunology.

Recognition of Toxoplasma gondii by TLR11 Prevents Parasite-Induced Immunopathology1

A. Sher, F. Yarovinsky, S. Hieny, 2008, The Journal of Immunology.

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

J. Andersen, A. Sher, A. Fairlamb, 2003, Nature Immunology.

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

A. Sher, G. Trinchieri, G. Besra, 2013, The Journal of Immunology.

The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments

A. Sher, C. Feng, G. Taylor, 2002, Infection and Immunity.

Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

A. Sher, F. Sutterwala, R. Flavell, 2010, The Journal of Immunology.

CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

A. Sher, J. Aliberti, M. Schito, 2000, Nature immunology.

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

A. Sher, G. Trinchieri, R. Kühn, 1996, Journal of immunology.

MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

A. Sher, C. Feng, C. Scanga, 2004, Infection and Immunity.

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

A. Sher, R. Germain, C. Sousa, 1997, The Journal of experimental medicine.

Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology.

A. Sher, J. Aliberti, M. Schito, 1999, Immunity.

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

A. Sher, R. Gazzinelli, A. Cheever, 1992, Journal of immunology.

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

A. Sher, R. Gazzinelli, I. Oswald, 1993, Journal of immunology.

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

A. Sher, T. Wynn, R. Gazzinelli, 1993, Proceedings of the National Academy of Sciences of the United States of America.

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

A. Sher, T. Wynn, E. Denkers, 1996, Journal of immunology.

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

R. Coffman, A. Sher, A. Cheever, 1990, Journal of immunology.

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

J. Berzofsky, A. Sher, E. Pearce, 1992, Journal of immunology.

Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis.

A. Sher, J. Dear, S. Hewitt, 2006, Kidney international.

In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.

A. Sher, Dragana Jankovic, P. Caspar, 2002, Immunity.

Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.

A. Sher, D. Barber, I. Sereti, 2010, Blood.

Persistent IL-12 Production Function in Chronic Tuberculosis Requires Maintenance of Pulmonary Th1 Effector

A. Sher, C. Feng, D. Jankovic, 2013 .

Maintenance of Pulmonary Th1 Effector Function in Chronic Tuberculosis Requires Persistent IL-12 Production

A. Sher, C. Feng, Dragana Jankovic, 2005, The Journal of Immunology.

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

A. Sher, T. Wynn, Dragana Jankovic, 1995, Journal of immunology.

Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice.

A. Sher, A. O’Garra, E. Murphy, 1993, Journal of immunological methods.

Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii

A. Sher, G. Trinchieri, R. Gazzinelli, 1996, Infection and immunity.

Linked in vivo expression of soluble interleukin‐4 receptor and interleukin‐4 in murine schistosomiasis

R. Fernandez-Botran, A. Sher, T. Wynn, 1995, European journal of immunology.

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

A. Sher, T. Wynn, Dragana Jankovic, 1996, Journal of immunology.

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

A. Sher, T. Wynn, Dragana Jankovic, 1995, Journal of immunology.

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

R. Coffman, A. Sher, P. Scott, 1990, Proceedings of the National Academy of Sciences of the United States of America.

NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis

A. Sher, H. Young, T. Wynn, 2006, The Journal of Immunology.

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms.

A. Sher, T. Wynn, Dragana Jankovic, 1999, Journal of immunology.

The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism inhibitable by interleukin‐10 and transforming growth factor‐β

A. Sher, R. Gazzinelli, S. James, 1992, European journal of immunology.

Cutting Edge: In Vivo Induction of Integrated HIV-1 Expression by Mycobacteria Is Critically Dependent on Toll-Like Receptor 2 1

A. Sher, M. Schito, C. Scanga, 2003, The Journal of Immunology.

D. Chaussabel, A. Sher, W. Watford, 2008, Nature Immunology.

Water-in-Oil–Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6–Dependent Pathway

Andrea J. Radtke, A. Sher, K. Shenderov, 2016, The Journal of Immunology.

A cyclic AMP inducible gene expressed during the development of infective stages of Trypanosoma cruzi.

A. Sher, S. Heath, S. Hieny, 1990, Molecular and biochemical parasitology.

Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.

R. Coffman, A. Sher, F. Yarovinsky, 2006, Immunity.

The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice.

A. Sher, T. Cox, A. Cheever, 1992, Memorias do Instituto Oswaldo Cruz.

CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells.

A. Sher, E. Denkers, R. Gazzinelli, 1991, Journal of immunology.

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

A. Sher, D. Sacks, S. Hieny, 1985, Journal of immunology.

Require TLR Signaling In Vivo and Does Not Mycobacterium tuberculosis Production Is Critical for Host Resistance to β Cutting Edge : Caspase-1 Independent IL-1 Sutterwala and

Cheever, A. Sher, Gabriel, 2010 .

The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii.

A. Sher, R. Germain, C. Reis e Sousa, 1998, Advances in experimental medicine and biology.

Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.

A. Sher, E. Denkers, R. Gazzinelli, 1993, Journal of immunology.

Mechanisms-Dependent Effector γ Cell-and IFN-Requires the Induction of Both B mansoni Schistosoma Optimal Vaccination Against Cheever and

A. Sher, T. Wynn, D. Jankovic, 1998 .

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

A. Sher, R. Gazzinelli, G. Shearer, 1991, Journal of immunology.

Mycobacterium tuberculosis with Response in T Cell-Deficient Hosts Infected Regulates Innate Resistance and Neutrophil Differentially γ NK Cell-Derived IFN -

H. Young, T. Wynn, C. Feng, 2006 .

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1β in Response to TLR4 Stimulation through a Caspase-8– and TRIF-Dependent Pathway

D. Green, A. Sher, A. Oberst, 2014, The Journal of Immunology.

Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. IV. Fractionation and antigenic properties of a soluble adult worm immunoprophylactic activity.

A. Sher, E. Pearce, S. James, 1986, Journal of immunology.

Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement.

A. Sher, R. Asofsky, S. James, 1982, Journal of immunology.

Host Resistance and Immune Deviation in Pigeon Cytochromec T-Cell Receptor Transgenic Mice Infected withToxoplasma gondii

A. Sher, R. Schwartz, G. Yap, 2000, Infection and Immunity.

Immune responses during human schistosomiasis mansoni. III. Regulatory effect of patient sera on human lymphocyte blastogenic responses to schistosome antigen preparations.

D. Colley, S. Hieny, J. A. Cook, 1977, The American journal of tropical medicine and hygiene.

Immunopathology of Schistosoma japonicum and S. mansoni infection in B cell depleted mice

A. Sher, A. Cheever, S. Hieny, 1985, Parasite immunology.

Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

J M Ward, A. Sher, J. Ward, 1998, Infection and Immunity.

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

A. Sher, A. Dzutsev, G. Trinchieri, 2012, Immunity.

Promastigotes Selectively Inhibit Interleukin 12 Induction in Bone Marrow-derived Macrophages from Susceptible and Resistant Mice

R. Badolato, Werner Müller, R. Gazzinelli, 1996 .

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

S. Akira, A. Sher, S. Ghosh, 2013, Immunity.

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

A. Sher, S. Gordon, D. Barber, 2011, Immunity.

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

A. Sher, J. Aliberti, M. Schito, 2000, Nature Immunology.

Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

Carmen M. Collazo-Custodio, A. Sher, C. Feng, 2003, The Journal of Immunology.

TLR 4-Deficient Animals by Toll-Like Receptor 2 ( TLR 2 )-and Infection Not Exhibited Mycobacterium avium Resistance and Immune Responses to 88 Display Profound Defects in Host Mice Lacking Myeloid Differentiation Factor

Carmen M. Collazo-Custodio, A. Sher, C. Feng, 2003 .

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

J. Andersen, A. Sher, F. Sutterwala, 2005, Science.

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

A. Sher, G. Trinchieri, E. Denkers, 1994, Journal of immunology.

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion

A. Sher, T. Nutman, K. Tosh, 2016, The Journal of Immunology.

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

A. Sher, F. Finkelman, T. Wynn, 1994, Journal of immunology.

Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies.

A. Sher, D. Sacks, L. Kirchhoff, 1985, Journal of immunology.

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

R Morawetz, A. Sher, T. Wynn, 1997, Journal of immunology.

Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. IV. Analysis of the role of IgE antibodies and mast cells.

A. Sher, R. Corrêa-Oliveira, R. Hussain, 1983, Journal of immunology.

Evidence against the existence of specific Schistosoma mansoni subpopulations which are resistant to irradiated vaccine-induced immunity.

A. Sher, F. Lewis, S. Hieny, 1985, The American journal of tropical medicine and hygiene.

Schistosome vaccines: current progress and future prospects

A. Sher, E. Pearce, R. Corrêa-Oliveira, 1989, Parasitology.

Induction of protective immunity against Schistosoma mansoni by vaccination with schistosome paramyosin (Sm97), a nonsurface parasite antigen.

A. Sher, E. Pearce, D. Lanar, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Lack of resistance to Schistosoma japonicum in mice immunized with irradiated S. mansoni cercariae.

A. Sher, A. Cheever, S. Hieny, 1983, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Immunity against Schistosomes in Murine Vaccine Models

A. Sher, E. Pearce, R. Corrêa-Oliveira, 1986 .

Cryptic epitope explains the failure of a monoclonal antibody to bind to certain isolates of Trypanosoma cruzi.

A. Sher, L. Kirchhoff, D. Snary, 1984, Journal of immunology.

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.

A. Sher, T. Wynn, R. Kühn, 1998, Journal of immunology.

gp72, the 72 kilodalton glycoprotein, is the membrane acceptor site for C3 on Trypanosoma cruzi epimastigotes

A. Sher, K. Joiner, L. Kirchhoff, 1985, The Journal of experimental medicine.

Mechanism and Gamma Interferon-Dependent ( IL-10 )-Deficient Mice through an IL-12-Specific-Pathogen-Free Interleukin-10 Triggers Colitis in Helicobacter hepaticus

A. Sher, J. Ward, D. Jankovic, 1998 .

Evasion of the alternative complement pathway by metacyclic trypomastigotes of Trypanosoma cruzi: dependence on the developmentally regulated synthesis of surface protein and N-linked carbohydrate.

A. Sher, K. Joiner, S. Hieny, 1986, Journal of immunology.

Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection

A. Sher, Sivaranjani Namasivayam, S. Hieny, 2020, Mucosal Immunology.

Heme oxygenase-1 inhibition promotes IFNγ and NOS2 mediated control of Mycobacterium tuberculosis infection

A. Sher, Robert W. Thompson, B. Andrade, 2020, Mucosal immunology.

Toxoplasma gondii Triggers Myeloid Differentiation Factor 88-Dependent IL-12 and Chemokine Ligand 2 (Monocyte Chemoattractant Protein 1) Responses Using Distinct Parasite Molecules and Host Receptors1

A. Sher, Soumaya Bennouna, B. Butcher, 2004, The Journal of Immunology.

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

A. Sher, C. Serhan, J. Aliberti, 2002, Nature Immunology.

-Dependent Effector γ Cell- and IFN- mansoni Requires the Induction of Both B Optimal Vaccination Against Schistosoma

Alan Sher, Sara Hieny, Patricia Caspar, 2013 .

Identification and characterization of protozoan products that trigger the synthesis of IL-12 by inflammatory macrophages.

A. Sher, M. Ferguson, R. Gazzinelli, 1997, Chemical immunology.

Mechanisms of protective immunity against 5. mansoni infection in mice vaccinated with irradiated cercariae. VI. Influence of the major histocompatibility complex

A. Sher, S. James, S. Hieny, 1984, Parasite immunology.

Mice Deficient in LRG-47 Display Increased Susceptibility to Mycobacterial Infection Associated with the Induction of Lymphopenia

Carmen M. Collazo-Custodio, A. Sher, Y. Belkaid, 2004, The Journal of Immunology.

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo.

A. Sher, J. Grivel, L. Margolis, 2009, Microbes and infection.

Differentiation Factor 88-Dependent IL-12 Triggers Myeloid Toxoplasma gondii

A. Sher, Soumaya Bennouna, B. Butcher, 2004 .

Signaling and the Inflammasome Mycobacteria through Mincle/CARD9 the Th17-Promoting Adjuvant Activity of Cord Factor and Peptidoglycan Recapitulate

A. Sher, G. Trinchieri, G. Besra, 2013 .

Macrophages as effector cells of protective immunity in murine schistosomiasis. VI. T cell-dependent, lymphokine-mediated, activation of macrophages in response to Schistosoma mansoni antigens.

P. Natovitz, S. James, S. Hieny, 1983, Journal of immunology.

Developmental differences determine larval susceptibility to nitric oxide-mediated killing in a murine model of vaccination against Schistosoma mansoni

A. Sher, I. Oswald, S. James, 1997, Infection and immunity.

Associated with the Induction of Susceptibility to Mycobacterial Infection Mice Deficient in LRG-47 Display Increased

Karen L. Elkins, Sara Hieny, Dragana Jankovic, 2013 .

Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii.

R. Gazzinelli, S. Hieny, Eduardo Grunvald, 1996, Infection and immunity.

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

A. Sher, S. Gordon, D. Barber, 2011, Immunity.

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

R. Badolato, Werner Müller, R. Gazzinelli, 1996, The Journal of experimental medicine.

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

A. Sher, A. Dzutsev, G. Trinchieri, 2012, Immunity.

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

S. Akira, A. Sher, S. Ghosh, 2013, Immunity.

Inflammasome-dependent IL-1 beta production is critical for complete Freund's adjuvant-induced helper T cell polarization

A. Sher, G. Trinchieri, G. Besra, 2010 .

In Vivo Microbial Stimulation Induces Rapid Cd40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and Their Redistribution to T Cell Areas

D. Jankovic, T. Scharton‐Kersten, S. Hieny, 1997 .