J. Hardin

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Identification of Autoantibodies to RNA Polymerase 11 Occurrence in Systemic Sclerosis and Association with Autoantibodies to RNA Polymerases

T. Medsger, J. Craft, U. Pati, 2013 .

Autoantibodies to glycyl-transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity.

J. Craft, I. Targoff, Y. Takeda, 1996, Arthritis and rheumatism.

Consequences of metabolic and oxidative modifications of cartilage tissue

L. Santambrogio, J. Hardin, N. Cobelli, 2015, Nature Reviews Rheumatology.

Antibodies to histones in systemic lupus erythematosus: localization of prominent autoantigens on histones H1 and H2B.

J. O. Thomas, J. Hardin, J. Thomas, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Induction of autoreactive B cells allows priming of autoreactive T cells

J A Hardin, C. Janeway, M. Mamula, 1991, The Journal of experimental medicine.

The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.

R. Jemmerson, M. Mamula, J. Hardin, 1990, Journal of immunology.

Electroarthrography: a novel method to assess articular cartilage and diagnose osteoarthritis by non-invasive measurement of load-induced electrical potentials at the surface of the knee.

P. Savard, M. Buschmann, P. Lavigne, 2013, Osteoarthritis and cartilage.

Association between autoantibodies to the Ku protein and DPB1*.

T. Mimori, Shinji Sato, M. Kuwana, 2005, Arthritis and rheumatism.

Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.

C. Janeway, M. Mamula, R. Lin, 1992, Journal of immunology.

Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

T. Mimori, A. Griffith, M. Akizuki, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells.

W. Dynan, K. McConnell, J. Hardin, 1997, Journal of Immunology.

Autoimmune response to transthyretin in juvenile idiopathic arthritis.

L. Santambrogio, C. Montagna, S. Porcelli, 2016, JCI insight.

Vitamin D does not modulate NF-kappaB activity in Jurkat T cells.

A. S. Shifera, D Leong, J. Hardin, 2010, Immunology letters.

Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity.

E. Haber, K. Bloch, J. Hardin, 1978, The American journal of medicine.

Mia M. Thi, G. Vunjak‐Novakovic, A. Urbanska, 2013, Chemistry & biology.

PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins.

A. S. Shifera, J. Hardin, 2009, Archives of biochemistry and biophysics.

Directing Autoimmunity to Nucleoprotein Particles

J. Hardin, 2003, The Journal of experimental medicine.

The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays.

J. Craft, J. Hardin, R. Kipnis, 1990, Arthritis and rheumatism.

Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides

T. Mimori, A. Griffith, J. Craft, 1992, Molecular Biology Reports.

Human RNA helicase A is a lupus autoantigen that is cleaved during apoptosis.

W. Dynan, G. Sharp, Y. Takeda, 1999, Journal of immunology.

ApoptosisAutoantigen That Is Cleaved During Human RNA Helicase A Is a Lupus

W. Dynan, G. Sharp, Y. Takeda, 1999 .

Nonautoimmune Mice Anti-Chromatin Autoimmunity in -Actinin Immunization Elicits α

R. Angeletti, C. Putterman, B. Deocharan, 2013 .

α-Actinin Immunization Elicits Anti-Chromatin Autoimmunity in Nonautoimmune Mice1

R. Angeletti, C. Putterman, B. Deocharan, 2007, The Journal of Immunology.

A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content.

J. Koziol, A. Wiik, Y. Takasaki, 2002, The Journal of rheumatology.

The Impact of Vitamin D on Dendritic Cell Function in Patients with Systemic Lupus Erythematosus

B. Diamond, I. Ben-Zvi, G. Gilkeson, 2010, PloS one.

Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent

E. Fikrig, R. Flavell, D. Rahn, 1991, Infection and immunity.

Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus.

J A Hardin, J. Steitz, J. Boyle, 1981, Science.

Structure and function of small ribonucleoproteins from eukaryotic cells.

Stephen M. Mount, J. Steitz, S. Mount, 1982, Princess Takamatsu symposia.

Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.

J. Steitz, M. Lerner, S. Wolin, 1982, The Journal of clinical investigation.

Deciphering the mysteries of RNA-containing lupus antigens.

J. Steitz, C. Janeway, M. Lerner, 1982, Arthritis and rheumatism.

Human monoclonal anti-La antibodies. The La protein resides on a subset of Ro particles.

E. Silverman, M. Mamula, R. Laxer, 1989, Journal of immunology.

Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit.

T. Mimori, W. Dynan, Y. Takeda, 1996, The Journal of clinical investigation.

The lupus autoantigens and the pathogenesis of systemic lupus erythematosus.

J. Hardin, 1986, Arthritis and rheumatism.

Reference sera for antinuclear antibodies. II. Further definition of antibody specificities in international antinuclear antibody reference sera by immunofluorescence and western blotting.

Y. Takasaki, E. Tan, M. Fritzler, 1997, Arthritis and rheumatism.

Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in Japanese patients with inflammatory muscle disease.

T. Mimori, J. Craft, M. Akizuki, 1992, Arthritis and rheumatism.

Fibrinopeptide A in plasma of normal subjects and patients with disseminated intravascular coagulation and systemic lupus erythematosus.

E. Haber, K. Bloch, J. Hardin, 1976, The Journal of clinical investigation.

Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles.

T. Mimori, A. Griffith, J. Craft, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin.

E. Fikrig, R. Flavell, D. Rahn, 1992, The Journal of infectious diseases.

The pathogenesis of arthritis in Lyme disease: humoral immune responses and the role of intra-articular immune complexes.

A. Steere, S. Malawista, J. Hardin, 1984, The Yale journal of biology and medicine.

Linked sets of antinuclear antibodies: what do they mean?

J. Craft, J. Hardin, 1987, The Journal of rheumatology. Supplement.

Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.

T. Medsger, J. Craft, U. Pati, 1993, The Journal of clinical investigation.

Autoantibodies that bind glomeruli: cross-reactivity with bacterial antigen.

B. Diamond, C. Kowal, J. Hardin, 2005, Arthritis and rheumatism.

The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes.

T. Mimori, J. Craft, J. Hardin, 1988, The Journal of clinical investigation.

Evidence for Pseudomonas antigen in immune complexes in Pseudomonas osteomyelitis.

A. Steere, D. Rahn, R. Grodzicki, 1982, Arthritis and rheumatism.

A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'.

M. Lerner, C. Schmauss, J. Hardin, 1989, Nucleic acids research.

Antibodies in human serum that precipitate ribonuclease P.

S. Altman, J. Craft, J. Hardin, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of human autoantibodies that selectively precipitate the 7SL RNA component of the signal recognition particle.

T. Mimori, N. Okada, J. Hardin, 1987, Journal of immunology.

Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts

B. Diamond, S. Kim, M. Khalil, 2008, The Journal of experimental medicine.

Therapeutic studies in NZB/W mice. III. Relationship between renal status and efficacy of immunosuppressive drug therapy.

A. Steinberg, D. Lowenthal, J. Hardin, 1975, Arthritis and rheumatism.

Different strains of donor parental lymphoid cells induce different models of chronic graft-versus-host disease in murine (Balb/c x A/J)F1 hybrid hosts.

J. Rodríguez-Sánchez, C. Juárez, M. A. Martínez, 1990, Clinical immunology and immunopathology.

Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.

E. Silverman, M. Mamula, R. Laxer, 1991, The Journal of rheumatology.

Autoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit.

J. Craft, Y. Takeda, J. Kanungo, 1996, Arthritis and rheumatism.

Detection of antibodies to small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins using unlabeled cell extracts.

T. Mimori, J. Hardin, C. Gelpí, 1985, Arthritis and rheumatism.

In vitro correction of anticoagulant activity and specific clotting factor assays in SLE.

R. Hoffman, N. Dainiak, J. Hardin, 1980, Thrombosis research.

Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling

H. Sun, J. Hardin, D. Leong, 2016, International journal of molecular sciences.

Range of antinuclear antibodies in "healthy" individuals.

J. Koziol, A. Wiik, Y. Takasaki, 1997, Arthritis and rheumatism.

Erythema Chronicum Migrans and Lyme Arthritis: The Enlarging Clinical Spectrum

A. Steere, S. Malawista, W. Andiman, 1977 .

Mediators of the inflammatory response to joint replacement devices

L. Santambrogio, G. Crisi, J. Hardin, 2011, Nature Reviews Rheumatology.

The Ro ribonucleoprotein particle: induction of autoantibodies and the detection of Ro RNAs among species.

J. Harley, M. Mamula, J. Hardin, 1989, Clinical immunology and immunopathology.

Mechanism of interaction between Ku protein and DNA.

J A Hardin, T. Mimori, T Mimori, 1986, The Journal of biological chemistry.

Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

J. Steitz, T. Mimori, J. Hardin, 1986, The Journal of biological chemistry.

Autoantibodies to ribonucleoproteins.

T. Mimori, J. Hardin, 1985, Clinics in rheumatic diseases.

Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis

H. Sun, J. Hardin, D. Leong, 2013, International journal of molecular sciences.

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

A. Griffith, J. Craft, P. Blier, 1993, The Journal of biological chemistry.

Autoantigenic epitopes of the B polypeptide of Sm small nuclear RNP particles. Identification of regions accessible only within the U1 small nuclear RNP.

T. Mimori, J. Craft, M. Akizuki, 1992, Arthritis and rheumatism.

Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins.

J. Rodríguez-Sánchez, J. Craft, M. A. Martínez, 1988, Journal of immunology.

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

T. Mimori, Y. Takeda, S. A. Jesch, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA.

T. Mimori, A. Griffith, P. Blier, 1992, The Journal of biological chemistry.

SIMULTANEOUS SYNTHESIS OF HISTONE AND DNA IN SYNCHRONOUSLY DIVIDING TETRAHYMENA PYRIFORMIS

J. Hardin, D. T. Lindsay, Gerald E. Einem, 1967, The Journal of cell biology.

Immune complexes and the evolution of Lyme arthritis. Dissemination and localization of abnormal C1q binding activity.

A. Steere, S. Malawista, J. Hardin, 1979, The New England journal of medicine.

Circulating immune complexes in Lyme arthritis. Detection by the 125I-C1q binding, C1q solid phase, and Raji cell assays.

A. Steere, S. Malawista, K. Tung, 1979, The Journal of clinical investigation.

Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission.

A. Steere, S. Malawista, S. Ruddy, 1979, Arthritis and rheumatism.

Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

J. Friedman, H. Sun, M. Navati, 2016, Arthritis Research & Therapy.

Chronic Lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis.

A. Steere, S. Malawista, R. Winchester, 1979, Annals of internal medicine.

Humoral suppression of erythropoiesis in systemic lupus erythematosus (SLE) and rheumatoid arthritis.

R. Hoffman, N. Dainiak, M. Callahan, 1980, The American journal of medicine.

A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity.

J. Koziol, Y. Takasaki, E. Tan, 1999, Arthritis and rheumatism.

Factors modulating expression of Renilla luciferase from control plasmids used in luciferase reporter gene assays.

A. S. Shifera, J. Hardin, 2010, Analytical biochemistry.

Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.

J. Craft, M. Hirakata, J. Hardin, 1993, Journal of immunology.

Dendritic Cell-Mediated In Vivo Bone Resorption

L. Santambrogio, C. Montagna, R. Maitra, 2010, The Journal of Immunology.

A human IgM M-protein in a patient with unknown bleeding disorder binds to β-galactosyl and β-glucosyl residues☆

S. Kusunoki, J. Craft, R. Yu, 1987 .

Therapeutic studies in NZB/W MICE

A. Steinberg, D. Lowenthal, J. Hardin, 1975 .

The chondroprotective role of CITED2 in post-traumatic osteoarthritis

H. Sun, M. Goldring, M. Schaffler, 2013 .

Application of Biomarkers in the Development of Drugs Intended for the Treatment of Osteoarthritis OARSI FDA Osteoarthritis Biomarkers Working Group

A R Poole, D Heinegård, R. Moskowitz, 2011 .

Spontaneous peritonitis and systemic lupus erythematosus. Importance of accurate diagnosis of gram-positive bacterial infections.

P. Lipsky, L. Schour, P. Plotz, 1975, JAMA.

Higher order structure is present in the yeast nucleus: autoantibody probes demonstrate that the nucleolus lies opposite the spindle pole body

M. Snyder, J. Craft, E. Lambie, 1989, Chromosoma.

The major core histone antigenic determinants in systemic lupus erythematosus are in the trypsin‐sensitive regions

J. Hardin, C. M. Wilson, Jean O. Thomas, 1984, FEBS letters.

Therapeutic Ultrasound: Osteoarthritis Symptom-Modification and Potential for Disease Modification

C. Guha, H. Sun, Huagang Zhang, 2013 .

DNA‐Dependent Protein Kinase (DNA‐PK)

W. Dynan, J. Hardin, 2002 .

A method to detect particle-specific antibodies against Ku and the DNA-dependent protein kinase catalytic subunit in autoimmune sera.

W. Dynan, J. Hardin, F. Jafri, 2001, Journal of immunological methods.

DNA-dependent protein phosphorylation activity in Xenopus is coupled to a Ku-like protein.

Y. Takeda, J. Kanungo, R. Cameron, 1997, The Biological bulletin.

Gradual Loss of a DNA-Inducible Protein Kinase Activity From the Cytoplasmic Extracts of Arbacia Embryos.

H. Rasmussen, Y. Takeda, J. Kanungo, 1996, The Biological bulletin.

A DNA-Inducible Kinase Activity Undergoes a Change in Cellular Localization During Development in Arbacia.

H. Rasmussen, J. Kanungo, D. Woodrum, 1996, The Biological bulletin.

Autoantigenic histone epitopes: a comparison between procainamide- and hydralazine-induced lupus.

J. Craft, R. Bernstein, M. Harding, 1987, Arthritis and rheumatism.

Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus.

B. Volpe, B. Diamond, S. Prabhakaran, 2005, The Journal of rheumatology.

Cyclophosphamide Treatment of Lymphoma During Third Trimester of Pregnancy

J. Hardin, 1972, Obstetrics and gynecology.

A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers' laboratories.

J. Koziol, A. Wiik, Y. Takasaki, 2003, The Journal of rheumatology.

Dendritic cells: potential triggers of autoimmunity and targets for therapy

J. Hardin, J. Hardin, 2005, Annals of the rheumatic diseases.

Anti-NOR 90. A new autoantibody in scleroderma that recognizes a 90-kDa component of the nucleolus-organizing region of chromatin.

J. Rodríguez-Sánchez, C. Juárez, J. Hardin, 1987, Journal of immunology.

Fifty Years of Segregation: Black Higher Education in Kentucky, 1904-1954

J. Hardin, J. Stephens, 1997 .

Human autoantibodies recognizing a native macromolecular structure composed of Sm core proteins in U small nuclear RNP particles.

K. Wise, W. Dynan, G. Sharp, 1998, Arthritis and rheumatism.

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model

D. Spray, H. Sun, M. Goldring, 2014, Arthritis Research & Therapy.

Green Tea Polyphenol Treatment Is Chondroprotective, Anti-inflammatory And Palliative In A Mouse Post-traumatic Osteoarthritis Model

Neil, Cobelli, D. Spray, 2015 .

Lyme disease: a unique human model for an infectious etiology of rheumatic disease.

A. Steere, S. Malawista, J. Hardin, 1984, The Yale journal of biology and medicine.

Nucleic Acids Research Nucleic Acids Research called Sm and the presence of circulating autoantibodies to it is patho-

G. Mcallister, C. Schmauss, J. Hardin, 2022 .

snRNPs and scRNPs as autoantigens: clues to the etiology of the connective tissue diseases

M. Mamula, J. Craft, G. Boire, 1990, Clinical Rheumatology.

Lyme arthritis: a new clinical entity.

A. Steere, S. Malawista, J. Hardin, 1978, Hospital practice.

Identification of human autoantibodies to transcription factor IIB.

S. Peterson, W. Dynan, F. Abendroth, 1995, Nucleic Acids Research.

Multiple heavy-chain determinants on individual B lymphocytes in the peripheral blood of patients with Sjögren's syndrome.

W. Paul, I. Green, J. Hardin, 1973, The New England journal of medicine.

SIMULTANEOUS SYNTHESIS OF HISTONE AND DNA IN SYNCHRONOUSLY DIVIDING TETRAHYMENA PYRIFORMIS

L. Latson, H. Jilaihawi, M. Saric, 1967, The Journal of cell biology.